Physics / Fizik
Permanent URI for this collectionhttps://hdl.handle.net/11147/6
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Article Citation - WoS: 1Citation - Scopus: 1Hdac9/P300 Immunoexpression and Migration Analysis for Malignant Melanoma Stem Cell(Elsevier, 2023) Özdil, Berrin; Asker Abdikan, Cemile Sinem; Özdemir, Merve; Erişik, Derya; Yesin, Taha Kadir; Avcı, Çığır Biray; Kurkutçu, Yeşim; Güler, Günnur; Aktuğ, HüseyinMelanoma is an aggressive tumor with a poor prognosis that worsens in the metastatic phase. Distruptions of epigenetic mechanisms is known to effect cancer stem cells (CSCs) activity. Malignant melanoma (MM) progression may be promoted by changes in the genetic structure of CSC. Thus, treatments that target epigenetic modifications could be a promising weapon, especially in melanoma. Here, we compared p300, HDAC9, and Factin proteins in melanoma CSCs (CD133+), non-CSCs (CD133-) and CHL-1 cell line, as well as cell migration and division rates. At 4 and 6 h, P300 protein levels in CHL-1 and CD133 + were remarkably similar, and the CD133- showed increases in expression levels as the incubation period lengthened. HDAC9 protein intensity decreased in CHL-1, increased in the CD133-, and remained relatively unchanged in the CD133+ as the incubation period lengthened. The mean value of F-actin expression level increased in all cell group with time, when the highest increase observed in CHL-1. In conclusion, our studies contribute to the management of metastatic diseases in the future and offer new insight into the molecular basis of the initiation and progression of MM.Article Citation - WoS: 12Citation - Scopus: 13Electronic and Magnetic Properties of Graphene Quantum Dots With Two Charged Vacancies(Elsevier, 2020) Kul, Erdoğan Bulut; Polat, Mustafa; Güçlü, Alev DevrimElectronic and magnetic properties of a system of two charged vacancies in hexagonal shaped graphene quantum dots are investigated using a mean-field Hubbard model as a function of the Coulomb potential strength ? of the charge impurities and the distance R between them. For ?=0, the magnetic properties of the vacancies are dictated by Lieb's rules where the opposite (same) sublattice vacancies are coupled antiferromagnetically (ferromagnetically) and exhibit Fermi oscillations. Here, we demonstrate the emergence of a non-magnetic regime within the subcritical region: as the Coulomb potential strength is increased to ??0.1, before reaching the frustrated atomic collapse regime, the magnetization is strongly suppressed and the ground state total spin projection is given by Sz=0 both for opposite and same sublattice vacancy configurations. When long-range electron–electron interactions are included within extended mean-field Hubbard model, the critical value for the frustrated collapse increases from ?cf?0.28 to ?cf?0.36 for R<27Å. © 2020 Elsevier LtdArticle Citation - WoS: 5Citation - Scopus: 5Defect Induced Anderson Localization and Magnetization in Graphene Quantum Dots(Elsevier, 2018) Altıntaş, Abdulmenaf; Güçlü, Alev DevrimWe theoretically investigate the effects of atomic defect related short-range disorders and electron-electron interactions on Anderson type localization and the magnetic properties of hexagonal armchair graphene quantum dots using an extended mean-field Hubbard model and wave packet dynamics for the calculation of localization lengths. We observe that randomly distributed defects with concentrations between 1 and 5% of the total number of atoms leads to localization alongside magnetic puddle-like structures. Although the localization lengths are not affected by interactions, staggered magnetism and localization are found to be enhanced if the defects are distributed unevenly between the sublattices of the honeycomb lattice.Article Citation - WoS: 16Citation - Scopus: 17Superconducting Gap and Pseudogap From Tunneling Conductance on Bi2sr2cacu2og+δ With Various Oxygen Concentration(Elsevier, 2000) Miyakawa, N.; Zasadzinski, J.F.; Ozyuzer, L.; Guptasarma, P.; Kendziora, C.; Hinks, D.G.; Gray, K.E.The evolution of tunneling spectra on Bi2Sr2CaCu2Og+δ measured by SIN point contacts, SIS break junctions and STM/STS has been studied as a function of doping and temperature. The detailed examinations of the spectra show that the energy gap measured at low temperature appear to be due to superconducting pairing. The doping dependence of the superconducting gap at low temperature suggests a strong connection to the pseudogap temperature, T*, and this indicates that the pseudogap region is at least partly a consequence of some form of precursor superconductivity. In addition, dip/hump structures observed at high bias scale approximately with not only Δ but also superexchange interaction J over the entire doping range examined, indicating these features are linked to the underlying interaction responsible for superconductivity. We suggest that the hump structure may originate from short-range magnetic correlations. © 2000 Elsevier Science B.V All rights reserved.