IZTECH Research Centers Collection / İYTE Araştırma Merkezleri Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11147/2636
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Article Citation - WoS: 1Citation - Scopus: 1Groundwater Recharge Estiaton in the Alaşehir Sub-Basin Using Hydro-Geochemical Data; Alaşehir Case Study(Springer, 2021) Tonkul, Serhat; Baba, Alper; Şimşek, Celalettin; Demirkesen, Ali CanThe issue of groundwater recharge has gained importance in countries where there is not enough water supply to the aquifer. However, groundwater recharge is a difficult parameter to determine. This difficulty stems from factors such as the location of the area to be studied, time, cost, and hydrological data. Numerical, isotope, and chemical approaches are used in groundwater recharge investigations. Numerical and chemical approaches are more costly and time-consuming than chemical approaches. This study aims to ascertain alluvial aquifer recharge in Alaehir (Manisa) sub-basin using chemical approaches (Chloride Mass Balance Method) and its applicability. For this purpose, research wells were drilled at 25 different points in the alluvial aquifer, water sampling was done in wet and dry periods, and rainwater water samples were collected. Groundwater recharge was calculated by using chemical approaches from the chloride concentrations of the water samples collected. An annual average of 74.84 mm of recharge was found in the Alaehir sub-basin. This value corresponds to 16.38% of annual rainfall. At the same time, it was examined the groundwater and geothermal mixing mechanism to demonstrate the applicability of the Chloride Mass Balance Method. It was concluded that geothermal fluid in Alaehir sub-basin mixed with groundwater at a rate of 17%.Article Citation - WoS: 5Citation - Scopus: 7Effect of High Salinity and Temperature on Water-Volcanic Rock Interaction(Springer, 2021) Gören, Ayşegül Yağmur; Gören, Ayşegül Yağmur; Topçu, Gökhan; Demir, Mustafa Muammer; Demir, Mustafa M.; Baba, Alper; Baba, AlperIn order to understand the processes occurring in natural hydrothermal systems, it was carried out a series of water-volcanic rock interaction studies in the laboratory and an intermediate volcanic rock samples from geothermal production wells in Tuzla geothermal field (TGF) in western Turkey. A high-pressure autoclave was used to conduct water-rock interaction experiments under similar conditions of the field. Rainwater and seawater were treated with volcanic rocks at 140 degrees C (reservoir temperature) and 4.5 bar pressure. The change in the ionic content of the resulting fluids was examined in terms of the type of volcanic rocks and mineral saturation index. The results indicate that talc and diopside minerals in geothermal systems may cause scaling at high temperatures depending on the geothermal fluid and pH.Article Citation - WoS: 3Citation - Scopus: 4Evaluation of Multifunctional Hybrid Analogs for Stilbenes, Chalcones and Flavanones(Bentham Science Publishers, 2017) Çağır, Ali; Odacı, Burcu; Varol, Mehmet; Akçok, İsmail; Okur, Özgür; Koparal, Ayşe T.Aims: In this study, discovery of novel anticancer agents acting by more than one mechanism was aimed. Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel stilbene-fused chalcones and stilbene-fused flavanones were tested for their aromatase inhibition, anti-angiogenic and anti-proliferative properties in cancer (PC3, MCF-7) and healthy (HUVEC) cell lines. MTT cell viability assay was used to evaluate the anti-proliferative activities of the compounds. CYP19/MFC high-throughput screening kit (BD Biosciences, Oxford, UK) was used to search the aromatase inhibition properties and matrigel tube formation assay was applied to determine the anti-angiogenic activities. Results: Results indicate that the simple-chalcone and flavanone derivatives were more cytotoxic than the simple-stilbenes in the both cancer cell lines. In contrast, the simple-stilbene structures were much more effective at aromatase inhibition. The cytotoxicity profiles of stilbene-fused chalcones in cancer cells imply that these molecules mostly mimic the simple chalcone structures. On the other hand, flavanones lose their cytotoxic activities after becoming fused with stilbenes. Additionally, aromatase inhibition assays showed that stilbene-fused chalcones again do mimic the simple-chalcones but not simple-stilbenes and anti-angiogenic profiles of the tested molecules seem to be not related with stilbene fragments. Furthermore, stilbene-fused flavanones may mimic both simple-flavanones and simple-stilbenes depending upon the type and position of the substituent in their respective terminal aromatic rings.