IZTECH Research Centers Collection / İYTE Araştırma Merkezleri Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11147/2636
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Article Citation - WoS: 3Citation - Scopus: 4Evaluation of Multifunctional Hybrid Analogs for Stilbenes, Chalcones and Flavanones(Bentham Science Publishers, 2017) Çağır, Ali; Odacı, Burcu; Varol, Mehmet; Akçok, İsmail; Okur, Özgür; Koparal, Ayşe T.Aims: In this study, discovery of novel anticancer agents acting by more than one mechanism was aimed. Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel stilbene-fused chalcones and stilbene-fused flavanones were tested for their aromatase inhibition, anti-angiogenic and anti-proliferative properties in cancer (PC3, MCF-7) and healthy (HUVEC) cell lines. MTT cell viability assay was used to evaluate the anti-proliferative activities of the compounds. CYP19/MFC high-throughput screening kit (BD Biosciences, Oxford, UK) was used to search the aromatase inhibition properties and matrigel tube formation assay was applied to determine the anti-angiogenic activities. Results: Results indicate that the simple-chalcone and flavanone derivatives were more cytotoxic than the simple-stilbenes in the both cancer cell lines. In contrast, the simple-stilbene structures were much more effective at aromatase inhibition. The cytotoxicity profiles of stilbene-fused chalcones in cancer cells imply that these molecules mostly mimic the simple chalcone structures. On the other hand, flavanones lose their cytotoxic activities after becoming fused with stilbenes. Additionally, aromatase inhibition assays showed that stilbene-fused chalcones again do mimic the simple-chalcones but not simple-stilbenes and anti-angiogenic profiles of the tested molecules seem to be not related with stilbene fragments. Furthermore, stilbene-fused flavanones may mimic both simple-flavanones and simple-stilbenes depending upon the type and position of the substituent in their respective terminal aromatic rings.Article Citation - WoS: 1Citation - Scopus: 1Triploid Induction of Green Tiger Shrimp, Penaeus Semisulcatus (de Haan, 1844) Using Temperature and Chemical Shock(John Wiley and Sons Inc., 2015) Kır, Mehmet; Tarhan, Gökhan; Okur, ÖzgürTriploidy in fertilized eggs of Penaeus semisulcatus was induced by temperature and chemical shocks. The eggs, which were obtained from the shrimp broodstock maintained at 29C, were exposed to cold temperature (8, 10, 12, and 14 C) and 6-dimetiloaminopurine (6-DMAP) concentrations (100, 150, 200, and 250 μM) for different durations (4, 6, and 8min) 9min after spawning was detected. While the highest triploidy rate of 49.7±4.5% was obtained with a 200μM 6-DMAP concentration for a duration of 8min, the best mean triploidy rate of 45.5±2.8% for cold shock was obtained at a temperature of 10 C for a duration of 8min. Temperature and 6-DMAP concentration did not have significant effect on triploidy rate (P>0.05) but shock duration had significant effect on triploidy rate for individual cold temperature shock or 6-DMAP chemical shock (P<0.05). Although longer durations of shock agent increased the rates of triploid induction, they generally had an adverse effect on hatching rates in the study.Article Citation - WoS: 1Citation - Scopus: 2Induction of Triploidy in Melicertus Kerathurus (forskal, 1775) With Temperature Shock(John Wiley and Sons Inc., 2016) Kır, Mehmet; Şahan, Ali Kemal; Okur, ÖzgürTriploidy in fertilized eggs of Melicertus kerathurus was induced by cold (8, 10, 12°C) and heat (34, 36, 38°C) shock for different duration times (2, 4 and 8 min) after 10 min of post spawning. The best individual treatment produced 64.5% triploid nauplii in cold shock application at a temperature of 10°C for a duration of 8 min. Temperature did not have significant effect (P > 0.05) on triploid rate but duration time had a significant effect (P < 0.05) for individual cold or heat shock. This study demonstrates that because of a wide variety of effective parameters, it is essential to optimize shock conditions for each species strain at each location. © 2016 John Wiley & Sons Ltd.