IZTECH Research Centers Collection / İYTE Araştırma Merkezleri Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/11147/2636
Browse
3 results
Search Results
Conference Object Citation - Scopus: 1Enterprise Systems Applications Development Plans To Build and Develop Robust and Environmentally Sensitive Green Logistics Systems Management Software(Springer Verlag, 2009) Yıldız, Türkay; Yercan, FundaWithin the concept of enterprise-wide development of environmentally sensitive systems' application modules to fully integrate all-in-one green logistics services principles have received much attention and consideration from practitioners, academia, and from the industry, for about more than a decade. However, by taking into the consideration of the multidisciplinary nature of the issue, large scale effective collaborative framework is needed to be developed. Therefore, utilization of UML diagrams, class definitions, defining class relationships, fields, tables, views, etc. so on play crucial roles in the design phases of the enterprise system. Thus, this article largely deals with the major logistics work processes and their interactions within the consideration of environmental engineering issues on business operations to address step-by-step process control mechanisms to provide necessary input to build robust-design and better implementation of the needed IT software backbone.Book Part Exergetic and Exergoeconomic Aspects of Ground-Source (geothermal) Heat Pumps in Turkey(Taylor & Francis, 2014) Hepbaşlı, Arif; Hancıoğlu Kuzgunkaya, EbruThe demand for energy has recently increased rapidly as a result of the world’s population increase and industrial growth. On the contrary, fossil fuel supply is declining due to depletion of the resources. Moreover, utilization of fossil fuel energy resources has resulted in adverse effects on the global environment. In this regard, there is an urgent need to implement the use of sustainable and environmentally clean energy sources. In this context, renewable energy sources, including geothermal sources, can play a critical role in meeting the energy demands of societies.Article Citation - WoS: 3Citation - Scopus: 4Evaluation of Multifunctional Hybrid Analogs for Stilbenes, Chalcones and Flavanones(Bentham Science Publishers, 2017) Çağır, Ali; Odacı, Burcu; Varol, Mehmet; Akçok, İsmail; Okur, Özgür; Koparal, Ayşe T.Aims: In this study, discovery of novel anticancer agents acting by more than one mechanism was aimed. Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel stilbene-fused chalcones and stilbene-fused flavanones were tested for their aromatase inhibition, anti-angiogenic and anti-proliferative properties in cancer (PC3, MCF-7) and healthy (HUVEC) cell lines. MTT cell viability assay was used to evaluate the anti-proliferative activities of the compounds. CYP19/MFC high-throughput screening kit (BD Biosciences, Oxford, UK) was used to search the aromatase inhibition properties and matrigel tube formation assay was applied to determine the anti-angiogenic activities. Results: Results indicate that the simple-chalcone and flavanone derivatives were more cytotoxic than the simple-stilbenes in the both cancer cell lines. In contrast, the simple-stilbene structures were much more effective at aromatase inhibition. The cytotoxicity profiles of stilbene-fused chalcones in cancer cells imply that these molecules mostly mimic the simple chalcone structures. On the other hand, flavanones lose their cytotoxic activities after becoming fused with stilbenes. Additionally, aromatase inhibition assays showed that stilbene-fused chalcones again do mimic the simple-chalcones but not simple-stilbenes and anti-angiogenic profiles of the tested molecules seem to be not related with stilbene fragments. Furthermore, stilbene-fused flavanones may mimic both simple-flavanones and simple-stilbenes depending upon the type and position of the substituent in their respective terminal aromatic rings.