Mechanical Engineering / Makina Mühendisliği
Permanent URI for this collectionhttps://hdl.handle.net/11147/4129
Browse
5 results
Search Results
Article Citation - WoS: 25Citation - Scopus: 27Trabecular Bone Recovers From Mechanical Unloading Primarily by Restoring Its Mechanical Function Rather Than Its Morphology(Elsevier Ltd., 2014) Özçivici, Engin; Judex, StefanUpon returning to normal ambulatory activities, the recovery of trabecular bone lost during unloading is limited. Here, using a mouse population that displayed a large range of skeletal susceptibility to unloading and reambulation, we tested the impact of changes in trabecular bone morphology during unloading and reambulation on its simulated mechanical properties. Female adult mice from a double cross of BALB/cByJ and C3H/HeJ strains (n = 352) underwent 3. wk of hindlimb unloading followed by 3. wk of reambulation. Normally ambulating mice served as controls (n = 30). As quantified longitudinally by in vivo μCT, unloading led to an average loss of 43% of trabecular bone volume fraction (BV/TV) in the distal femur. Finite element models of the μCT tomographies showed that deterioration of the trabecular structure raised trabecular peak Von-Mises (PVM) stresses on average by 27%, indicating a significant increase in the risk of mechanical failure compared to baseline. Further, skewness of the Von-Mises stress distributions (SVM) increased by 104% with unloading, indicating that the trabecular structure became inefficient in resisting the applied load. During reambulation, bone of experimental mice recovered on average only 10% of its lost BV/TV. Even though the addition of trabecular tissue was small during reambulation, PVM and SVM as indicators of risk of mechanical failure decreased by 56% and 57%, respectively. Large individual differences in the response of trabecular bone, together with a large sample size, facilitated stratification of experimental mice based on the level of recovery. As a fraction of all mice, 66% of the population showed some degree of recovery in BV/TV while in 89% and 87% of all mice, PVM and SVM decreased during reambulation, respectively. At the end of the reambulation phase, only 8% of the population recovered half of the unloading induced losses in BV/TV while 50% and 49% of the population recovered half of the unloading induced deterioration in PVM and SVM, respectively. The association between morphological and mechanical variables was strong at baseline but progressively decreased during the unloading and reambulation cycles. The preferential recovery of trabecular micromechanical properties over bone volume fraction emphasizes that mechanical demand during reambulation does not, at least initially, seek to restore bone's morphology but its mechanical integrity.Article Citation - WoS: 8Citation - Scopus: 9Quantitative Trait Loci That Modulate Trabecular Bone's Risk of Failure During Unloading and Reloading(Elsevier Ltd., 2014) Özçivici, Engin; Zhang, Weidong; Donahue, Leah Rae; Judex, StefanGenetic makeup of an individual is a strong determinant of the morphologic and mechanical properties of bone. Here, in an effort to identify quantitative trait loci (QTLs) for changes in the simulated mechanical parameters of trabecular bone during altered mechanical demand, we subjected 352. second generation female adult (16. weeks old) BALBxC3H mice to 3. weeks of hindlimb unloading followed by 3. weeks of reambulation. Longitudinal in vivo microcomputed tomography (μCT) scans tracked trabecular changes in the distal femur. Tomographies were directly translated into finite element (FE) models and subjected to a uniaxial compression test. Apparent trabecular stiffness and components of the Von Mises (VM) stress distributions were computed for the distal metaphysis and associated with QTLs. At baseline, five QTLs explained 20% of the variation in trabecular peak stresses across the mouse population. During unloading, three QTLs accounted for 14% of the variability in peak stresses. During reambulation, one QTL accounted for 5% of the variability in peak stresses. QTLs were also identified for mechanically induced changes in stiffness, median stress values and skewness of stress distributions. There was little overlap between QTLs identified for baseline and QTLs for longitudinal changes in mechanical properties, suggesting that distinct genes may be responsible for the mechanical response of trabecular bone. Unloading related QTLs were also different from reambulation related QTLs. Further, QTLs identified here for mechanical properties differed from previously identified QTLs for trabecular morphology, perhaps revealing novel gene targets for reducing fracture risk in individuals exposed to unloading and for maximizing the recovery of trabecular bone's mechanical properties during reambulation.Article Citation - WoS: 30Citation - Scopus: 36Crushing and Energy Absorption Characteristics of Combined Geometry Shells at Quasi-Static and Dynamic Strain Rates: Experimental and Numerical Study(Elsevier Ltd., 2015) Taşdemirci, Alper; Şahin, Selim; Kara, Ali; Turan, Ali KıvançThe quasi-static and dynamic crushing response and the energy absorption characteristics of combined geometry shells composed of a hemispherical cap and a cylindrical segment were investigated both experimentally and numerically. The inelastic deformation of the shells initiated with the inversion of the hemisphere cap and followed by the axisymmetric or diamond folding of the cylindrical segment depending on the loading rate and dimensions. The fracture of the thinner specimens in dynamic tests was ascribed to the rise of the flow stress to the fracture stress with increasing strain rate. The hemisphere cap absorbed more energy at dynamic rates than at quasi-static rates, while it exhibited lower strain rate and inertia sensitivities than the cylinder segment. For both the hemisphere cap and the cylinder segment, the inertial effect was shown to be more pronounced than strain rate effect at increasing impact velocities. © 2014 Elsevier Ltd.Article Citation - WoS: 59Citation - Scopus: 66A Novel Concept of Convertible Roofs With High Transformability Consisting of Planar Scissor-Hinge Structures(Elsevier Ltd., 2010) Akgün, Yenal; Gantes, Charis J.; Kalochairetis, Konstantinos E.; Kiper, GökhanIn this paper, a new adaptive scissor-hinge structure is introduced, which can be converted by means of actuators between a multitude of curvilinear arch-like shapes, where it can be stabilized and carry loads. The key point of this new structure is the proposed Modified Scissor-Like Element (M-SLE). With the development of this element, it becomes possible to change the geometry of the whole system without changing the dimensions of the struts or the span. The proposed scissor-hinge structure discussed here is planar, but it is also possible to combine structures in groups to create spatial systems. After outlining the differences of the proposed structure with existing designs, the dimensional properties of the M-SLE are introduced. Then, geometric principles and shape limitations of the whole structure are explained. Finally, structural analysis of the structure in different geometric configurations is performed, in order to discuss stiffness limitations associated with the advantage of increased mobility. © 2010 Elsevier Ltd.Article Citation - WoS: 16Citation - Scopus: 19A Novel Finite Element Model for Vibration Analysis of Rotating Tapered Timoshenko Beam of Equal Strength(Elsevier Ltd., 2010) Yardımoğlu, BülentA new finite element model based on the coupled displacement field and the tapering functions of the beam is formulated for transverse vibrations of rotating Timoshenko beams of equal strength. In the coupled displacement field, the polynomial coefficients of transverse displacement and cross-sectional rotation are coupled through consideration of the differential equations of equilibrium. The tapering functions of breadth and depth of the beam are obtained from the principle of equal strength in the longitudinal direction of the beam. After finding the displacement functions using the tapering functions, the stiffness and mass matrices are expressed by using the strain and kinetic energy equations. A semi-symbolic computer program in Mathematica is developed and subsequently used to evaluate the new model. The results of the illustrative example regarding the problem indicated in the title of this paper are obtained and compared with the results found from the models created in ABAQUS. Very good agreement is found between the results of new model and the other results. © 2010 Elsevier B.V.