Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Recent Developments in the Treatment of Leishmaniasis: Natural Compounds, Drug Targets, in Silico Molecular Docking Approaches, and Nanocarriers(Elsevier B.V., 2025) Gürbüz Çolak, N.; 01. Izmir Institute of TechnologyLeishmaniasis is a common tropical disease caused by Leishmania protozoa. It affects 0.9 to 1.6 million people, causing 20,000–30,000 deaths annually. There are no effective vaccines, and current treatments have severe side effects. Drug resistance is a major obstacle in treating leishmaniasis. The necessity of drug discovery is indisputable. Natural compounds are promising candidates for drug discovery studies because of their diverse chemical structures and bioactivities. Experimental screening of compound libraries imposes high costs and is time-consuming. The molecular docking approach is beneficial for exploring new therapeutics in silico as it allows the screening of millions of drug candidates. Even if new drug candidates are discovered, delivery of the active ingredient to the target remains controversial. Nanocarriers are promising nanosystems that can address the drawbacks of drug delivery. This chapter focuses on natural compounds as drug candidates, targets, in silico drug discovery, and drug delivery for the treatment of leishmaniasis. © 2025 Elsevier Inc.Article Citation - WoS: 5Citation - Scopus: 4Comparative Proteomic Analysis of Leishmania Parasites Isolated From Visceral and Cutaneous Leishmaniasis Patients(Cambridge University Press, 2021) Dinç, Melike; Yalçın, Talat; Yalçın, Talat; Özbilgin, Ahmet; 04.01. Department of Chemistry; 04. Faculty of Science; 01. Izmir Institute of TechnologyLeishmaniasis is an infectious disease in which different clinical manifestations are classified into three main forms as visceral, cutaneous, and mucocutaneous. These disease forms are associated with parasite species of protozoan genus, Leishmania. For instance, Leishmania infantum and Leishmania tropica are typically linked with visceral (VL) and cutaneous (CL) leishmaniasis respectively, however these two species can also cause other form to a lesser extent. What is more alarming is this characteristic, which threatens classic diagnoses and therapies, is started to be acquired by other species. To address this issue, gel-based and gel-free proteomic analyses were carried out on the species, Leishmania infantum to determine the proteins differentiating between the parasites caused visceral and cutaneous leishmaniasis. In addition, Leishmania tropica parasites representing the typical cases for cutaneous leishmaniasis were included. Electrophoresis gels of parasites caused to visceral leishmaniasis were distinguishable from the others in terms of repetitive down-regulation on some specific locations. In addition, a distinct spot of an antioxidant enzyme, superoxide dismutase was shown up only on the gels of cutaneous leishmaniasis samples regardless of the species. In the gel-free approach, 37 proteins which were verified with a second database search using a different search engine, were distinguished from the comparison between VL and CL samples. Among them, 31 proteins for the CL group and 6 proteins for the VL group were determined differentially abundant. Two proteins from the gel-based analysis namely pyruvate kinase and succinly-coA:3-ketoacid-coenzyme A transferase analysis were encountered in the protein list of the CL group.