Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - Scopus: 7How Do the Influent Cod/Nitrogen and Internal Recirculation Ratios Affect the Oxidation Ditch Type Pre-Anoxic Landfill Leachate Treatment?(Academic Press, 2021) Çakirgöz,M.; Bayrakdar,A.; Çalli,B.A design-based dynamic simulation tool was developed to evaluate the effects of altered operation conditions on the performance of a landfill leachate treating pre-anoxic oxidation ditch folowed by external ultra filtration and nano filtration membranesby using the actual influent data and operational constants collected for 18 months. In the summer of 2017, the MBR suffered from reduced membrane fluxes due to deterioration of activated sludge flocs after the failure of flow booster providing the internal circulation and decreasing influent C/N ratio. Although two external pumps were activated in place of the broken flow booster, the required internal recirculation ratio (IR) predicted by the simulation could not be provided. It was concluded that due to low IR, the activated sludge retaining longer in the anoxic tank lost its floc integrity and caused decreased membrane fluxes. Simulation findings also showed that if the COD/N ratio drops below 4.8, no matter how high the IR is, it is unlikely to achieve a NOx-N concentration below 30 mg/l in the effluent. On the other hand, contrary to expectations, both the actual and estimated nitrification efficiencies were very high due to the moderately high temperature (>20 °C) and DO (2–3 mg/l) values in the aerobic basin. © 2020 Elsevier LtdArticle Citation - WoS: 4Citation - Scopus: 4On Schrödinger Operators Modified by Δ Interactions(Academic Press, 2023) Akbaş, Kaya Güven; Erman, Fatih; Turgut, O. TeomanWe study the spectral properties of a Schrödinger operator H0 modified by δ interactions and show explicitly how the poles of the new Green's function are rearranged relative to the poles of original Green's function of H0. We prove that the new bound state energies are interlaced between the old ones, and the ground state energy is always lowered if the δ interaction is attractive. We also derive an alternative perturbative method of finding the bound state energies and wave functions under the assumption of a small coupling constant in a somewhat heuristic manner. We further show that these results can be extended to cases in which a renormalization process is required. We consider the possible extensions of our results to the multi center case, to δ interaction supported on curves, and to the case, where the particle is moving in a compact two-dimensional manifold under the influence of δ interaction. Finally, the semi-relativistic extension of the last problem has been studied explicitly. © 2023 Elsevier Inc.Article Citation - WoS: 9Citation - Scopus: 8White Bean and Hazelnuts Flours: Application in Gluten-Free Bread(Academic Press, 2023) Tuna, Ayça; Cappa, Carola; Tokatlı, Figen; Alamprese, CristinaThis study investigated the effects of white bean and hazelnut flour addition (15–30% alone or in combination) to a rice flour-corn starch mixture in gluten-free (GF) breads formulated according to a mixture design. The chemical composition of flours and pasting properties of their mixtures were investigated, as well as the spectroscopic characteristics and leavening performance of doughs. Physical properties of fresh and stored (up to 48 h) bread samples were analyzed. Bean and hazelnut flours had higher protein and fiber contents, and lower carbohydrates content than rice flour and corn starch. Although the reference bread made of rice flour-corn starch mixture (STD) resulted in the highest specific volume (7.0 mL/g) and the lowest hardness (0.43 N), the sample enriched with 15% hazelnut flour (H15) approached these characteristics the most (3.8 mL/g and 1.59 N, respectively). After 48 h of storage, H15 also showed lower hardness than STD. This study paves the way for new applications of white bean and hazelnut flours and showed as a simple reformulation can help to develop healthier bread: the European legal constraint for “fiber source” claim was achieved for breads with 15 or 30% hazelnut flour, and 30% bean-hazelnut mixture, with a fiber content of 3.34, 4.48, and 3.27 g/100g, respectively. © 2023 The AuthorsArticle Citation - WoS: 12Citation - Scopus: 12Evaluation of Adjuvant Activity of Astragaloside Vii and Its Combination With Different Immunostimulating Agents in Newcastle Disease Vaccine(Academic Press, 2021) Yakuboğulları, Nilgün; Çöven, Furkan Ozan; Cebi, Nusin; Çöven, Fethiye; Çöven, Nejdet; Genç, Rukan; Bedir, ErdalAstragaloside VII (AST-VII), a major cycloartane saponin isolated from Turkish Astragalus species, turned out to be one of the most active metabolites demonstrating Th1/Th2 balanced immune response. As Quillaja saponins are extensively used in adjuvant systems, this study made an attempt to improve AST-VII based adjuvant systems by using different immunostimulatory/delivery agents (monophosphoryllipid A (MPL), Astragalus polysaccharide (APS) and squalene) and to induce cellular and humoral immune response against a viral vaccine. For this purpose, Newcastle Disease vaccine (NDV) was chosen as a model vaccine. Swiss albino mice were immunized subcutaneously with LaSota vaccines in the presence/absence of AST-VII or developed adjuvant systems. AST-VII administration both in live/inactivated LaSota vaccines induced neutralizing and NDV specific IgG, IgG1 and IgG2b antibodies response as well as IL-2 and IL-4 production. APS based delivery systems enhanced the production of neutralizing antibody and the minor augmentation of IFN-? and IL-2 levels. Squalene emulsion (SE) alone or combined with AST-VII were effective in NDV restimulated splenocyte proliferation. As a conclusion, AST-VII and AST-VII containing adjuvant systems demonstrated Th1/Th2 balanced antibody and cellular immune responses in NDV vaccines. Thus, these systems could be developed as vaccine adjuvants in viral vaccines as alternative to saponin-based adjuvants.Article Citation - WoS: 2Citation - Scopus: 2Novel 2 '-alkoxymethyl Substituted Klavuzon Derivatives as Inhibitors of Topo I and Crm1(Academic Press, 2020) Çetinkaya, Hakkı; Yıldız, Mehmet Salih; Kutluer, Meltem; Alkan, Aylin; Otaş, Hasan Ozan; Çağır, AliIn this work, 2'-alkoxymethyl substituted klavuzon derivatives were prepared starting from 2-methyl-1-naphthoic acid in eight steps. Anticancer potencies of the synthesized compounds were evaluated by performing MTT cell viability test over cancerous and healthy pancreatic cell lines, along with CRM1 inhibitory properties in HeLa cells by immunostaining and Topo I inhibition properties by supercoiled DNA relaxation assay. Their cytotoxic activities were also presented in hepatocellular carcinoma cells (HuH-7) derived 3D spheroids. Among the tested klavuzon derivatives, isobutoxymethyl substituted klavuzon showed the highest selectivity of cytotoxic activity against pancreatic cancer cell line. They showed potent Topo I inhibition while their CRM1 inhibitory properties somehow diminished compared to 4'-alkylsubstituted klavuzons. The most cytotoxic 2'-methoxymethyl derivative inhibited the growth of the spheroids derived from HuH-7 cell lines and PI staining exhibited time and concentration dependent cell death in 3D spheroids.Article Citation - WoS: 5Citation - Scopus: 5Nanoscale Curved Dielectric Film Characterization Beyond Diffraction Limits Using Spatially Structured Illumination(Academic Press, 2020) Ataç, Enes; Dinleyici, Mehmet SalihOptical fiber based sensor systems often utilize thin dielectric films coated on non-planar surfaces are needed to be inspected for quality assurance. However, non-destructive optical characterization of these films is not a simple method especially on curved large surfaces. In this study, we propose a real time procedure to estimate the optical properties of sub-wavelength transparent dielectric films coated on optical fibers. The paper includes developing a mathematical model and its experimental verification. The near field phase diffraction method is combined with the structured light illumination that is spatial modes of optical fibers to estimate the thickness of the phase object beyond the classical diffraction limits. Numerical simulations and experimental results show that the film thickness can safely be characterized up to one tenth of wavelength of interest via selective spatial field distribution determined according to the morphology of the thin film. The outcomes have good agreements with destructive Scanning Electron Microscope (SEM) measurements. © 2020 Elsevier Inc.Article Citation - WoS: 11Citation - Scopus: 10Ir Spectroscopy and Chemometrics for Physical Property Prediction of Structured Lipids Produced by Interesterification of Beef Tallow(Academic Press, 2019) Aktaş, Ayşe Burcu; Alamprese, Cristina; Fessas, Dimitrios; Özen, BanuThe aim of this study was the application of infrared spectroscopy and chemometrics to predict slip melting point (SMP), melting points at different melted fat percentages (MP85, MP90, MP95), and consistency of structured lipids to provide fast and reliable methods for their characterization. Tallow was chemically or enzymatically interesterified with corn, canola, or safflower oils, at different ratios. Fourier-transform mid-infrared (FT-IR) and near-infrared (FT-NIR) spectra of melted and solid samples were collected. Partial-least-square regression models constructed after different spectra pre-treatments and variable selection were satisfactory. The best models were obtained with solid sample FT-NIR spectra: in cross-validation, determination coefficients and root mean square errors were, respectively, 0.85 and 1.7 degrees C for SMP, 0.85 and 2.8 degrees C for MP90, and 0.91 and 14 MPa for consistency. Infrared spectroscopy can be considered a promising tool to determine physical properties of interesterified fats.Article Citation - WoS: 1Citation - Scopus: 1Discrete Fractional Integral Operators With Binary Quadratic Forms as Phase Polynomials(Academic Press, 2019) Temur, Faruk; Sert, EzgiWe give estimates on discrete fractional integral operators along binary quadratic forms. These operators have been studied for 30 years starting with the investigations of Arkhipov and Oskolkov, but efforts have concentrated on cases where the phase polynomial is translation invariant or quasi-translation invariant. This work presents the first results for operators with neither translation invariant nor quasi-translation invariant phase polynomials. (C) 2019 Elsevier Inc. All rights reserved.Article Citation - WoS: 12Citation - Scopus: 13Synthesis and Biological Evaluation of New Chloro/Acetoxy Substituted Isoindole Analogues as New Tyrosine Kinase Inhibitors(Academic Press, 2020) Köse, Aytekin; Kaya, Meltem; HorasanKishalı, Nurhan; Akdemir, Atilla; Şahin, Ertan; Kara, Yunus; Şanlı Mohamed, GülşahWe have developed a versatile synthetic approach for the synthesis of new isoindole derivatives via the cleavage of ethers from tricyclic imide skeleton compounds. An exo-cycloadduct prepared from the Diels-Alder reaction of furan and maleic anhydride furnished imide derivatives. The epoxide ring was opened with Ac2O or Ac2O/AcCl in the presence of a catalytic amount of H2SO4 in order to yield new isoindole derivatives 8a-d and 9a-d. The anticancer activity of these compounds was evaluated against the HeLa cell lines. The synthesized compounds showed inhibitory effects on the viability of HeLa cells and the degree of cytotoxicity was increased with the level of bigger branched isoindole derivatives. To better understand the acting mechanism of these molecules, western blot analysis was performed with using mTOR and its downstream substrates. In addition, human mTOR and ribozomal S6 kinase beta 1 (RS6K beta 1) have been investigated with molecular modelling studies as possible targets for compound series 8 and 9.Article Citation - WoS: 29Citation - Scopus: 29A Two-Stage Bayesian Algorithm for Finite Element Model Updating by Using Ambient Response Data From Multiple Measurement Setups(Academic Press, 2020) Hızal, Çağlayan; Turan, GürsoyThis study presents a two-stage Bayesian finite element model updating procedure by using acceleration response measurements obtained from multiple setups. In the presented methodology, parametric uncertainties for the modal parameters are estimated by using the Bayesian Fast Fourier Transform Approach (BFFTA). Different from the previous Bayesian methods, a block diagonal covariance matrix is modeled for prior estimation of measured modal parameters. In addition, the modelling error in the eigenvalue equations is considered as soft constraints to be updated. Numerical and experimental studies are presented to validate the proposed method. The effect of soft constraints on the identification results as well as their posterior uncertainties are investigated. According to the results, it is shown that the proposed methodology can identify the most probable finite element model parameters with high level of accuracy. In addition, the posterior uncertainties obtained by the proposed procedure are significantly small when compared to the methods that consider rigid constraints for prediction and/or modelling error. (C) 2019 Elsevier Ltd. All rights reserved.