Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Self-Assembled Peptide Hydrogels with Cell Attachment Motifs for 3D Lung Cancer Model: Evaluation of Cell-Matrix Interactions and Drug Response(John Wiley and Sons Inc, 2026) Top, Ayben; Tamburaci, S.; Top, A.; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology3D cancer models can mimic the tumor microenvironment, serving as a physiologically relevant platform to investigate the behavior of tumors and test anticancer therapeutics. Although bioactive peptide hydrogels have been widely evaluated for tissue engineering applications, their potential in 3D cancer models has been confirmed in only a few studies. In this study, self-assembling peptide hydrogels containing LDV (IBP1) and LDV and IKVAV cell attachment motifs (IBP2), and the control hydrogel without adhesion units (KLEI) were used for lung cancer modeling. The peptides self-assembled into hydrogels in a cell culture medium with storage moduli of ∼700–1500 Pa. The IBP1 and IBP2 hydrogels enhanced A549 cell proliferation and induced the formation of spheroids with average diameters between ∼70 and ∼150 µm. The cells in KLEI hydrogel with the highest stiffness exhibited mesenchymal-type migration, independent of the cell population, whereas transformation to mesenchymal migration necessitated a specific cell population in the IBP2 hydrogel. The cells in the IBP1 and IBP2 hydrogels with enhanced cell-cell interactions demonstrated higher resistance to docetaxel (DTX). Thus, our results indicate that these bioactive hydrogels can serve as a promising platform for in vitro assessment of cancer mechanisms and drug screening. © 2026 Wiley-VCH GmbH.Correction Citation - WoS: 1Erratum: Bioactive Snail Mucus-Slime Extract Loaded Chitosan Scaffolds for Hard Tissue Regeneration: the Effect of Mucoadhesive and Antibacterial Extracts on Physical Characteristics and Bioactivity of Chitosan Matrix (Biomedical Materials (Bristol) (2021) 16 (065008) Doi: 10.1088/1748-605x(IOP Publishing, 2023) Perpelek, M.; Tıhmınlıoğlu, Funda; Aydemi̇r, S.; Tıhmınlıoğlu, F.; Baykara, B.; Karakaşli, A.; Havitçioǧlu, H.; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyThe authors regret that some errors were identified in 'figures 12 and 13' on pages 14 and 15, in the published manuscript concerning fluorescence microscopy images of Saos-2 and SW1353 cells on scaffolds for 1 and 3 d of incubation. The fluorescence images in figures 12 and 13 were mistakenly used as duplicated due to the inadvertently mislabeling during the processing of files and integrating them into the final figures. Intensity data regarding corrected fluorescence images were also measured and corrected. The revised figures (figures 12 and 13) and their captions appear below. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. (Figure Presented). © 2023 IOP Publishing Ltd.