Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Access type: Metadata onlySubject: search.filters.subject.Additive Manufacturing

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  • Article
    Novel Strut-Based Mechanical Analysis: Flow Stress Determination of Electron Beam Melt (EBM) Lattice Structures
    (Springernature, 2025) Bin Riaz, Muhammad Arslan; Erten, Hacer Irem; Guden, Mustafa
    In modeling lattices, the material flow stress equation, such as the Johnson and Cook (JC) equation, is usually determined from the mechanical tests conducted on bulk, relatively large test size specimens which were manufactured using the same process parameters with the lattices. However, the flow stresses of struts were shown in several studies to be significantly lower than those of large size test specimens. To overcome this discrepancy, a novel approach that combined the strut compression test, the strut double shear test (DST) and the numerical model of the strut DST using the JC equation was proposed. The study confirmed that the flow stress determined from the machined bulk tension test specimens overestimated the experimental compression stress-strain behavior of a body centered cubic (BCC) Ti6Al4V lattice. The flow stress parameters determined from the compression stress-strain curves of the as-printed strut specimens, on the other side, showed the best match to the experimental compression stress-strain behavior of the BCC lattice. The fidelity of the determined parameters of the JC equation was further verified with the experimental and numerical DSTs. It was also shown that the numerical iterations of DST model could be used for the fine-tuning the flow stress parameters.
  • Article
    Citation - Scopus: 1
    Recent Advances in Hydrogel-Based 3D Disease Modeling and Drug Screening Platforms
    (2025) Bilginer-Kartal, R.; Çoban, B.; Yildirim-Semerci, Ö.; Arslan-Yildiz, A.
    Three-dimensional (3D) disease modeling and drug screening systems have become important in tissue engineering, drug screening, and development. The newly developed systems support cell and extracellular matrix (ECM) interactions, which are necessary for the formation of the tissue or an accurate model of a disease. Hydrogels are favorable biomaterials due to their properties: biocompatibility, high swelling capacity, tunable viscosity, mechanical properties, and their ability to biomimic the structure and function of ECM. They have been used to model various diseases such as tumors, cancer diseases, neurodegenerative diseases, cardiac diseases, and cardiovascular diseases. Additive manufacturing approaches, such as 3D printing/bioprinting, stereolithography (SLA), selective laser sintering (SLS), and fused deposition modeling (FDM), enable the design of scaffolds with high precision; thus, increasing the accuracy of the disease models. In addition, the aforementioned methodologies improve the design of the hydrogel-based scaffolds, which resemble the complicated structure and intricate microenvironment of tissues or tumors, further advancing the development of therapeutic agents and strategies. Thus, 3D hydrogel-based disease models fabricated through additive manufacturing approaches provide an enhanced 3D microenvironment that empowers personalized medicine toward targeted therapeutics, in accordance with 3D drug screening platforms. © 2025. The Author(s), under exclusive license to Springer Nature Switzerland AG.