Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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  • Article
    Citation - Scopus: 2
    Flavonoids as Chemosensitizers in Leukemias
    (2025) Huseynova, N.; Çetinkaya, M.; Baran, Z.; Khalilov, R.; Mammadova, A.; Baran, Y.
    Flavonoids, a diverse group of natural compounds abundant in plants, fruits, and seeds, are not only responsible for the vibrant colors, fragrances, and flavors found in nature but also possess significant health benefits. Representing a secondary metabolite, these phytonutrients contribute to overall well-being. They have garnered considerable interest due to their diverse biological roles, encompassing antioxidant, anti-inflammatory, and anticancer properties. Flavonoids exert anticancer properties by interfering with different signaling pathways and molecules. Also, they have been demonstrated to exert chemosensitization features, where flavonoids may enhance the effectiveness of chemotherapy, and hold promise for improving cancer treatment outcomes as they have been discovered to make cancer cells more responsive to treatment. Understanding their influence on the regulation of cellular signaling provides a foundation for exploring their potential in combination with different chemotherapy agents and their possible single use for cancer treatment. Besides, they are believed to present a cost-effective approach to cancer therapeutics with possible implications for reducing the side effects of the current chemotherapy regimens, which can be a great therapeutic strategy for treating cancer types, including leukemia. This chapter explores potential approaches for creating anticancer treatments, focusing on leukemia, through integrating flavonoid nutraceuticals with traditional chemotherapy agents. © 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.
  • Book Part
    Citation - Scopus: 20
    Flavonoids in Cancer Therapy: Current and Future Trends
    (Elsevier, 2020) Gürler,S.B.; Kiraz,Y.; Baran,Y.
    Flavonoids are a family of polyphenolic photochemical that are naturally found in plants. Flavonoids have been widely studied due to the curiosity of scientists about the implementation of nature to human health. These experimental and epidemiological studies showed that flavonoids have beneficial effects such as antioxidation, antiinflammation, antiplatelet, antiallergic, antiaging, antidiabetic, and anticarcinogenic activity. They can also interact with and regulate cellular proteins, transcription factors, and signaling enzymes at the molecular level. Cancer is one of the most common problems in human health and millions of people die due to cancer every year. Due to the lack of completely efficient therapies for most cancer patients, new approaches should be discovered. Flavonoids have been investigated and many studies have confirmed their importance as a therapy option in many diseases. In this chapter we review the use of flavonoids as therapeutical agents and prevention for cancer, including the recent studies as well as future perspectives in the field. © 2020 Elsevier Inc. All rights reserved.