Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article A Machine Learning Framework for Advanced Analytical Detection of CD36 Using Immunosensors Below Limit of Detection(Elsevier Ltd, 2026) Yeke, M.C.; Gelen, S.S.; Fil, H.; Yalcin, M.M.; Gumus, A.; Yazgan, I.; Odaci, D.We introduce a machine learning (ML)-based regression framework for quantitative electrochemical analysis, representing a paradigm shift from traditional univariate methods to a multivariate approach. Conventional analysis is constrained by reducing the entire signal to a single peak current feature to define a linear range and calculate a limit of detection (LOD). In contrast, our methodology treats the Differential Pulse Voltammetry (DPV) curve as time-series data, creating a high-dimensional fingerprint by systematically evaluating multiple data windows with varying widths around the main signal peak to identify the most informative segment. To validate this approach, a biosensor was developed by immobilizing Anti-CD36 antibodies on polydopamine-modified screen-printed carbon electrodes for the detection of CD36, a key protein in metabolism and immunity. Measurements were collected across 12 concentrations, including blank samples, spanning a range of 0 to 25 ng/mL. Following data augmentation, nine different regression models were evaluated, with the top-performing models achieving near-perfect prediction accuracy (R2>0.99) across this entire range. This high accuracy across the full concentration spectrum quantitatively demonstrates the method's ability to operate without relying on traditional concepts like linear range or LOD, enabling reliable detection at ultra-low levels. Furthermore, the immunosensor exhibited high selectivity against common interferents and excellent recovery in human serum. This methodology represents a significant advancement in analytical electrochemistry, providing a transferable approach for enhancing sensitivity in biomarker detection with potential applications in clinical diagnostics and biomedical research. The codes and dataset are made publicly available on GitHub to support further research: https://github.com/miralab-ai/biosensors-AI. © 2026 The Author(s)Article Predicting the Area Moment of Inertia of Beam and Column Using Machine Learning and Hypernetexplorer(Springer Science and Business Media Deutschland GmbH, 2025) Aydın, Y.; Nigdeli, S.M.; Roozbahan, M.; Bekdaş, G.; Işıkdağ, Ü.Beams and columns are the most important elements of steel frame structures. Damage to the beam or column can lead the structure to serious hazards and cause collapse. In the structural engineering literature, it has been observed that there is not much work for area moment of inertia estimation of beam and column. The aim of this study was to predict the area moment of inertia of beam and column using HyperNetExplorer developed by the authors. This method aims to bring innovation by optimizing artificial neural networks (ANNs). In this study, a prediction study is performed using 306 collected data on beam and column area moment of inertia. Classical ML models (linear regression (LR), decision tree regression (DTR), K neighbors regression (KNN), polynomial regression (PR), random forest regression (RFR), gradient boosting regression (GBR), histogram gradient boosting regression (HGBR)) and NAS and HyperNetExplorer were applied to predict beam and column area moment of inertia. The prediction performances were compared using different performance metrics (coefficient of determination (R2) and mean squared error (MSE)) and HyperNetExplorer developed by the authors showed the highest performance (R2 = 0.98, MSE = 246.88). Furthermore, SHapley additive explanations (SHAP) were used to explain the effects of features in the prediction models and it was observed that the most effective features for model predictions were loading on beam and length. The results show that the proposed NAS base approach and the developed tool, HyperNetExplorer, provides better performance when compared with classical ML methods. © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2025.