Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Access type: Open accessAuthor: search.filters.author.Tepeli, Dilek

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  • Article
    The Effect of Co-Delivery of Oxygen and Antibacterial Drug Gentamicin From Alginate-Based Nanocomposite Hydrogels on Bacterial Apoptosis and Cell Viability
    (Wiley-v C H verlag Gmbh, 2025) Demir, Yagmur Damla; Ergul, Elif; Tepeli, Dilek; Demirci, Eylem Kurulgan; Pehlivanoglu, Pelin; Kehr, Nermin Seda
    There is a need to develop multifunctional biomaterials that can deliver oxygen and antibacterial drugs together for effective wound healing applications. Here, we report a novel biomaterial capable of co-delivering O2 and the antibacterial drug Gentamicin (GEN) for a period of 7 and 15 days, respectively. This biomaterial is fabricated by the synthesis of perfluorocarbon-based periodic mesoporous organosilica (PMOF) and the loading of its pores with GEN (GENPMOF). The synthesized GENPMOF is incorporated in alginate hydrogel to obtain Alg-GENPMOF with O2 and GEN co-delivery ability. Our results show that PMOF and GENPMOF have concentration-dependent toxicity on both Gram-negative E. coli and Gram-positive S. aureus bacteria. The most effective concentration of PMOF and GENPMOF (0.5 mg/mL) show little toxic effect for fibroblast cells. On the other hand, Alg-PMOF and Alg-GENPMOF prepared using this concentration require a long incubation time with E. coli to induce apoptosis. However, an incubation period of 1 day is sufficient to inhibit the growth of S. Aureus. Furthermore, Alg-PMOF and Alg-GENPMOF increase fibroblast cell viability under both normoxic and hypoxic conditions while slightly decreasing cancerous Malme-3M cell viability within 5 days of incubation.
  • Article
    Development of Chemometrics Method Based on Infrared Spectroscopy for the Determination of Cement Composition and Process Optimization [article]
    (ACG Publications, 2022) Özdemir, Durmuş; Gümüş, Mehmet Gökhan; Tepeli, Dilek
    In combination with a multivariate calibration method, FTIR-ATR spectroscopy was presented as a rapid method for the determination of some major oxides (CaO, SiO2, Al2O3, Fe2O3) and minor oxides (MgO, SO4, Na2O, and K2O) in diverse materials (raw material, raw meal, additives, clinker, and types of cement) in cement manufacturing. The FTIR spectroscopy based multivariate models were generated by taking X-ray fluorescence (XRF) as a reference method. Among a number of spectral preprocessing methods, extended multiplicative scatter correction (EMSC) yielded the best PLS models. The standard error of prediction (SEP) for the optimal FTIR based PLS models ranged from 0.10 to 2.07 (w/w%), and the regression coefficient (R2) ranged from 0.95 to 0.99 for PLS predicted vs XRF reference plots. Statistical evaluation of the both methods was carried out by paired t-test at the 95% confidence level and the results showed that the FTIR-ATR combined with PLS model results are consistent with the XRF reference measurements for all the oxides studied. Compared to the XRF method, which can take anywhere from a few minutes to an hour for each measurement, the proposed method is faster, cheaper, and safer. The presented technology also allows rapid monitoring of a cement factory production line.