Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Conference Object Redundancy resolution options for the twin-it-romans robotic hybrid manufacturing system(Springer Science and Business Media B.V., 2025) Gündüz, G.M.; Dede, Mehmet İsmet Can; Kiper, Gökhan; Schmitz, M.; Corves, B.The Twinnig Iztech in Robotics Manufacturing System (TWIN-IT-ROMANS) project funded by EU Horizon -Widera-2023-Access-02-01 aims to develop a hybrid manufacturing system that can perform additive and subtractive manufacturing processes and inline quality control using a robotic system. The system will incorporate a 6-degree-of-freedom robot arm and a positioner with 2-degree-of-freedom, which will operate synchronously. This manipulation system is to be designed for performing different manufacturing operations with different degrees-of-freedom requirements. In order to reveal alternative trajectory planning scenarios for this system, this paper presents an initial review of redundancy resolution approaches for kinematically redundant robotic manipulators. First, the four main approaches for redundancy resolution techniques are introduced. Then main studies on energy minimization and stiffness maximization for kinematically redundant robotic manipulators are reviewed. Similar or new approaches are planned to be generated and implemented for the redundant system for hybrid manufacturing. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.Conference Object Towards Sustainable Manufacturing: a Review and Future Directions in Additive Manufacturing of Fiber-Reinforced Polymer Composites(Springer Science and Business Media B.V., 2025) Türkcan, M.Y.; Tetik, Halil; Kurt, B.; Dede, Mehmet İsmet Can; Karaş, B.; Tetik, H.; Shokrani, A.; Dede, M.İ.C.The United Nations Sustainable Development Goals (SDGs) provide a global framework for addressing critical challenges such as climate change, resource scarcity and sustainable industrialization. With increasing demand for products and improving quality of life, linear consumption of materials and resources following the “take-make-waste” is no longer possible. As such, innovative solutions are increasingly necessary to enable circular economy in manufacturing. Additive manufacturing (AM) has emerged as a transformative technology in achieving SDGs by enhancing resource efficiency and minimizing waste. Fiber reinforced composites are a promising application of AM, as they offer the potential to optimize material use, reduce labor and support sustainable production practices. However, there is an urgent need for considering circular economy strategies, life cycle assessment (LCA) frameworks and effective recycling at the end of their lifetime. This study examines additive manufacturing systems for fiber-reinforced composites, their environmental impact and exploring the potential contributions of robotic integration in composite manufacturing to enhanced sustainability. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025.Article Assessment of Cytotoxic Potentials of Isoindole-Derived Compounds With Epoxy Alcohol Functionalities on Different Cancer Cell Lines and Molecular Docking Analysis(Maik Nauka/Interperiodica/Springer, 2025) Yetiskin, Egehan; Gundogdu, Ozlem; Mete, Derya; Kishali, Nurhan H.; Kara, Yunus; Sanli-Mohamed, GulsahObjective: Isoindoline and epoxycyclohexane derivatives are known to exert beneficial effects on various inflammatory pathologies, including cancer. This study uniquely evaluates the cytotoxic potential of four synthesized isoindoline derivatives against five different cancer cell lines. Methods: Cancer cell lines were treated with varying concentrations of each derivative and incubated for 24, 48, and 72 h. Cytotoxicity was assessed via cell growth inhibition assays and cell membrane damage tests. Additionally, molecular docking studies were conducted to examine the interaction of the compounds with key cancer-related proteins: human tankyrase 1, c-MET, estrogen receptor alpha, androgen receptor, and EGFR. Results and Discussion: The epoxy alcohol derivatives demonstrated a dose-dependent cytotoxic effect, inhibited cell proliferation, and induced membrane damage in adenocarcinoma cell lines. Apoptosis rates and in vitro wound healing assays further supported their antiproliferative potential. Conclusions: These findings suggest that epoxy isoindole derivatives may serve as promising anticancer agents for the treatment of cervical, lung, prostate, and breast cancers due to their cytotoxic and antiproliferative activities. Molecular docking results corroborated their potential mechanism of action.Article Understanding the Synthesis Mechanism of Arginine Functionalized Silver/Silver Chloride Nanoparticles Using Sugar Ligands(Elsevier, 2025) Bolat, Suheda; Degirmenci, Suna; Gumus, Abdurrahman; Sancak, Zafer; Yazgan, DrisIn this study, we performed a mechanistic study to understand how the sugar ligand chemistry affected the morphology, size and surface chemistry of Ag/AgCl_NPs synthesized in the presence of L-Arginine hydrochloride and L-Arginine/KCl mixture. The sugar ligands Lactose p-methoxyaniline (LMA) and Galactose 5-aminosalicylic acid (G5AS) resulted in formation of sheet-like Ag/AgCl_NPs while Lactose sulfanilic acid (LSA) and Lactose psulfonyldianiline (LPSA) caused the formation of anisotropic and film-like Ag/AgCl_NPs. The UV-Vis based mechanistic studies showed that the presence of Arginine posed a strong effect on how G5AS and LMA ligands interact with silver ions while the effect was more complicated for the LSA and LPSA ligands due to the fact that they form complexation with Ag+ ions. The mechanism was further investigated using infrared (IR) studies that showed the increases in Argine and chloride ion concentrations resulted in differentiation of the surface chemistry of the Ag/AgCl_NPs, and appearance of Arginine related IR bands became clearer in the case of cointroduction of Arginine and the sugar ligands. The characterized nanoparticles were then used as antibacterial agent for multidrug resistant Escherichia coli species for which less than 10 mu M minimum inhibitory concentrations were obtained. The promising antibacterial activity, which could be assigned to the presence of Arginine, was independent from the sugar ligand chemistry and nanoparticles' morphology and size. Particularly, large Ag/AgCl_NP film forming capacity can call further research to be exploited as coating materials for antibacterial application.Conference Object Citation - WoS: 3Citation - Scopus: 5Predicting Software Functional Size Using Natural Language Processing: an Exploratory Case Study(IEEE, 2024) Unlu, Huseyin; Tenekeci, Samet; Ciftci, Can; Oral, Ibrahim Baran; Atalay, Tunahan; Hacaloglu, Tuna; Demirors, OnurSoftware Size Measurement (SSM) plays an essential role in software project management as it enables the acquisition of software size, which is the primary input for development effort and schedule estimation. However, many small and medium-sized companies cannot perform objective SSM and Software Effort Estimation (SEE) due to the lack of resources and an expert workforce. This results in inadequate estimates and projects exceeding the planned time and budget. Therefore, organizations need to perform objective SSM and SEE using minimal resources without an expert workforce. In this research, we conducted an exploratory case study to predict the functional size of software project requirements using state-of-the-art large language models (LLMs). For this aim, we fine-tuned BERT and BERT_SE with a set of user stories and their respective functional size in COSMIC Function Points (CFP). We gathered the user stories included in different project requirement documents. In total size prediction, we achieved 72.8% accuracy with BERT and 74.4% accuracy with BERT_SE. In data movement-based size prediction, we achieved 87.5% average accuracy with BERT and 88.1% average accuracy with BERT_SE. Although we use relatively small datasets in model training, these results are promising and hold significant value as they demonstrate the practical utility of language models in SSM.Article Cx32 Cellular Localization Is Related To Epithelial To Mesenchymal Transition in Breast Cells(Pleiades Publishing inc, 2025) Oz, Sercan; Turan, Fatma Basak; Yondem, Eyup; Pesen-Okvur, Devrim; Yalcin-Ozuysal, Ozden; Ozcivici, Engin; Mese, GulistanConnexins (Cx) play both gap junction-related and -independent roles in cells, and their localization is essential for their function in cellular processes. Besides membrane localization, connexins can also be localized to the cytoplasm and nucleus, especially in cancer cells. The differential localization of connexins including Cx32 was observed in different stages of cancers. Cx32 was upregulated and observed in cytoplasms of cells in lymph-node metastasis of breast cancer samples compared to primary tumors. However, the significance of the increase in Cx32 expression and alteration of Cx32 cellular localization in epithelial-to-mesenchymal transition (EMT) is not known. To determine if Cx32 overexpression and/or localization over one week would induce the EMT process, we first examined the cellular localization of Cx32 in MCF10A and MDA-MB-231 cells at different time points using Western blot and RT-PCR as well as immunostaining with confocal microscopy. Then, we correlated the changes of Cx32 expression and localization with EMT marker expression. We showed that Cx32 had altered cellular localization and Cx32 overexpression increased Slug levels while it reduced E-cadherin and Snail expression in MDA-MB-231 for 7 days. In contrast, E-cadherin and Vimentin were reduced in MCF10A-Cx32 cells compared with controls over 7 days, and the expression pattern for nuclear Cx32 and Zeb2 was following similar pattern in MCF10A cells. Our results suggest a previously unknown time-dependent relation between Cx32 and the regulation of the EMT process.Article Citation - Scopus: 1Multi-Layer Absorber Based on Plasmonic Resonances for Photovoltaic Applications at Visible Spectra(Prof.Dr. İskender AKKURT, 2024) Demirhan, Y.This paper introduces a broadband absorber based on a multilayered, double-cylindrical-shaped metamaterial, numerically characterized for its performance. The structure comprises four interacting layers that generate plasmonic resonances. CST microwave simulations were conducted to analyze its absorption characteristics. The results demonstrate that the proposed metamaterial absorber achieves 99% absorption at 847 nm frequency region and 98% absorption in the 500-1200 nm frequency region. Additionally, polarization dependency analysis confirms that the absorber performs as a perfect, polarization-independent absorber across the studied frequency range. It exhibits high absorption in both TE and TM modes and remains unaffected by polarization or variations in the incident angle. Numerical simulations reveal that the absorption performance is driven by a combination of Fabry–Perot resonance effects, localized surface plasmons, and propagating surface plasmons. In summary, the proposed metastructure demonstrates omnidirectional absorption, polarization independence, and wide-angle incident absorption. This design shows significant potential for applications in photodetectors, active optoelectronic devices, and sensors. © IJCESEN.Article Kentlerin Depreme Dirençliliğinin Bina Bazlı Bölgesel Risk Dağılımı Yöntemi İle İncelenmesi: İzmit Kenti Örneği(Afet ve Acil Durum Yonetimi Baskanligi, 2024) Kurt, Deniz Gerçek; Guven, Ismaıl Talıh; Erdogan, HakanTürkiye, yıkıcı deprem üretme potansiyeli yüksek fay hatlarının yer aldığı bir bölgede konumlanmaktadır. Tarih boyunca, Anadolu yarımadasında meydana gelen depremler büyük can ve mal kayıplarına sebep olmuştur. Bu bağlamda, nüfusun ve sanayileşmenin çok yoğun olduğu Marmara Bölgesinde deprem risk değerlendirme çalışmalarının yoğunlaşması ve gerekli önlemlerin alınması büyük önem arz etmektedir. Bu çalışmada, 6306 sayılı \"Afet Riski Altındaki Alanların Dönüştürülmesi Hakkında Kanun\" kapsamında tanımlanan binaların bölgesel deprem riski dağılımının belirlenmesi için riskli yapıların tespitine ilişkin esaslar başlığı altında öngörülen basitleştirilmiş yöntemler kullanılarak Kocaeli ili İzmit ilçesinde bulunan 19940 bina incelenmiştir. Söz konusu yöntem, hızlı sokak taraması prensiplerini dikkate alarak bölgesel deprem risk önceliklendirmesini hedeflemektedir. Saha incelemelerinden elde edilen sonuçlar, nüfus yoğunluğu ve dağılımı, acil toplanma alanı dağılımı, toplam yapı alanı gibi parametrelerle beraber değerlendirilerek İzmit ilçesinde deprem risk öncelikli bölgelerin belirlenmesine çalışılmıştır.Review Citation - WoS: 1Citation - Scopus: 2Organ-On Platforms for Drug Development, Cellular Toxicity Assessment, and Disease Modeling(Tubitak Scientific & Technological Research Council Turkey, 2024) Khurram, Muhammad Maaz; Cinel, Gokturk; Yesil Celiktas, Ozlem; Bedir, ErdalOrgans-on-chips (OoCs) or microphysiological platforms are biomimetic systems engineered to emulate organ structures on microfluidic devices for biomedical research. These microdevices can mimic biological environments that enable cell-cell interactions on a small scale by mimicking 3D in vivo microenvironments outside the body. Thus far, numerous single and multiple OoCs that mimic organs have been developed, and they have emerged as forerunners for drug efficacy and cytotoxicity testing. This review explores OoC platforms to highlight their versatility in studies of drug safety, efficacy, and toxicity. We also reflect on the potential of OoCs to effectively portray disease models for possible novel therapeutics, which is difficult to achieve with traditional 2D in vitro models, providing an essential basis for biologically relevant research.Article Citation - Scopus: 3University Librarians’ Perceptions of Artificial Intelligence, Its Application Areas in Libraries, and The Future(University and Research Librarians Association (UNAK), 2024) Gürdal, Gültekin; Çuhadar, Sami; Mert, Selma; Gezer, Çağatay; Helvacıoğlu, Ece; Arus, Oya; Aslan, Özlem; Karslı, Melahat; Sönmez, Çiğdem; Taş, Ali; Açıkalın, Cansu; Mazlumoğlu, Ayça Aydemir; Erken, Mehmet; Yılmaz, Müberra; Çerkez, Özlem Araz; Uğur, Emrullah; Menemenlioğlu, Alper; Şenoğlu, Aysel; Atlı, Songül; Cuhadar, Sami; Gurdal, Gultekin; Erken, Mehmet; Mert, Selma; Gezer, Cagatay; Helvacıoğlu, Ece; Atli, SongülGünümüzde kütüphaneler, değişen teknoloji ve yeniliklerden etkilenen kurumlar arasında yer almaktadır. Yapay zeka teknolojilerinin popüler hale gelmesi, kütüphane hizmetlerini de dönüştürmeye başlamıştır. Bu araştırmada, Türkiye’deki üniversite kütüphanelerinin yapay zeka teknoloji ve uygulamalarının gelişim sürecinde yapmış olduğu ve yapmayı planladığı düzenlemeleri tespit etmek ve ilgili döneme özel geliştirdikleri hizmetleri belirlemek amacıyla bir anket uygulanmıştır. Anket, Türkiye’deki 208 üniversite kütüphanesinden 111 üniversite kütüphanesi yöneticisinin katılımıyla gerçekleştirilmiştir. Verilerin analizi ile üniversite kütüphanelerinin yapay zeka teknolojileri ve uygulamaları hakkındaki durumu, bilgi ve farkındalık düzeyleri belirlenmiş, eksik ve zayıf yönlerin geliştirilmesine yönelik önlemler ve öneriler sunulmuştur. İlgili araştırma, yapay zeka konusunda Türkiye’de üniversite kütüphanesi yöneticilerinden görüş ve öneri alarak gerçekleştirilen ilk ve en kapsamlı çalışmadır. Araştırma bulguları, üniversite kütüphanelerinin ChatGPT, Gemini, Grammarly vb. yapay zeka uygulamalarını belirli düzeyde kullandıklarını ancak yapay zeka ile ilgili kurumsal politika geliştirme, personele yetkinlik kazandırma ve planlama konularında ihtiyaçlarının olduğu ortaya çıkmıştır.