Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 7Citation - Scopus: 11Hydrophobic Deep Eutectic Solvent Effect on Acrylic Acid Separation From Aqueous Media by Using Reactive Extraction and Modeling With Response Surface Methodology(Taylor & Francis, 2022) Lalikoğlu, Melisa; Aşçı, Yavuz Selim; Sırma Tarım, Burcu; Yıldız, Mahmut; Arat, RefikHydrophobic deep eutectic solvents (HDES) are new-generation green solvents that have emerged in recent years. In this study, the efficiency of using HDES as a solvent in separating acrylic acid from its aqueous solution by reactive extraction method was investigated. As a solvent, HDES prepared with a mixture of TOPO and menthol has been used for the recovery of acrylic acid for the first time. Physical properties of HDES mixtures such as density, viscosity, and refractive index were determined. In reactive extraction experiments, TOPO, one of the two basic components in the solvent, was also employed as an extractant. With the help of response surface methodology based on Box-Behnken design, the effect of the parameters of amount of extractant (0.1–0.9 g), Menthol/TOPO molar ratio (2–4), and initial acid concentration (3–9%) on the distribution coefficient was investigated and the model equation was formed. The highest distribution coefficient (D = 7.8) was achieved with the molar ratio of Menthol/TOPO is 2. Upon examining all the results obtained, it was seen that more than 90% of acrylic acid could be extracted from the aqueous phase to the organic phase.Article Citation - WoS: 11Citation - Scopus: 16Influence of Menthol on Caffeine Disposition and Pharmacodynamics in Healthy Female Volunteers(Springer Verlag, 2003) Gelal, Ayşe; Güven, Hülya; Balkan, Dilara; Artok, Levent; Benowitz, Neal L.Objectives: The present study was undertaken to determine whether a single oral dose of menthol affects the metabolism of caffeine, a cytochrome P 450 1A2 (CYP1A2) substrate, and pharmacological responses to caffeine in people. Methods: Eleven healthy female subjects participated in a randomized, double-blind, two-way crossover study, comparing the kinetics and effects of a single oral dose of caffeine (200 mg) in coffee taken together with a single oral dose of menthol (100 mg) or placebo capsules. Serum caffeine concentrations and cardiovascular and subjective parameters were measured throughout the study. Results: Co-administration of menthol resulted in an increase of caffeine tmax values from 43.6 ± 20.6 min (mean ± SD) to 76.4 ± 28.0 min (P<0.05). The Cmax values of caffeine were lower in the menthol phase than in the placebo phase, but this effect was not statistically significant (P=0.06). (AUG)0-24, (AUC)0-∞, terminal half-life and oral clearance were not affected by menthol. Only nine subjects' cardiovascular data were included in the analysis because of technical problems during the measurements. After caffeine, heart rate decreased in both treatment phases. The maximum decrease in heart rate was less in the menthol phase (-8.9 ± 3.9 beats/min) than in the placebo phase (-13.1 ± 2.1 beats/min) (P = 0.024). There were no statistically significant differences in systolic and diastolic blood pressures between the two treatments. Conclusions: We conclude that a single oral dose of pure menthol (100 mg) delays caffeine absorption and blunts the heart-rate slowing effect of caffeine, but does not affect caffeine metabolism. The possibility that menthol slows the absorption of other drugs should be considered.