Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Author: search.filters.author.Özalp, Veli CengizInstitution Author: search.filters.institutionAuthor.Ahmetoğlu, Çekdar Vakıf

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  • Article
    Citation - WoS: 3
    Citation - Scopus: 2
    Targeted Multidrug Delivery Systems To Kill Antibiotic-Resistant Staphylococcus Aureus
    (Editions de Sante, 2023) Özalp, Veli Cengiz; Ahmetoğlu, Çekdar Vakıf; Ucak, Samet; Dursun, Ali D.; Sudağıdan, Mert; İçin, Öykü; Ahmetoğlu, Çekdar Vakıf; Henning, Laura M.; Simon, Ulla; Gurlo, Aleksander; 03.09. Department of Materials Science and Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Different ordered mesoporous silica (OMS) nanoparticles, ranging from regular COK-12 to COK-12 modified in terms of pore shape and size, have been employed as standard drug carriers for the controlled adsorption and release of drug molecules in comparison to well-known OMS SBA-15 and MCM-41. The cytotoxicity analysis demonstrated that regular COK-12 particles were less harmful to mammalian cultured cells, causing lower apoptosis induction than modified COK-12, MCM-41, and SBA-15 particles. Thus, regular COK-12 was further used to prepare a dual antibiotic-loaded drug delivery material, followed by surface functionalization with Staphylococcus aureus-specific aptamers for targeting. The results demonstrated that the joint loading of lysozyme and vancomycin in regular COK-12 improved the ability of the antibiotic treatments to kill methicillin-resistant Staphylococcus strains via aptamer targeting. The minimum inhibitory concentration (MIC) values decreased 4.1-fold and 12-fold compared to the non-targeted use of the antimicrobial agents in homogeneous solutions for vancomycin and lysozyme, respectively, clearly demonstrating the high potential of COK-12 to be used as a carrier in multidrug therapy. © 2023 Elsevier B.V.
  • Correction
    Citation - Scopus: 1
    Corrigendum To “hierarchically Porous Polymer Derived Ceramics: a Promising Platform for Multidrug Delivery Systems”[mater. Des. 140(supplement C) (2018) 37–44]
    (Elsevier Ltd., 2018) Ahmetoğlu, Çekdar Vakıf; Ahmetoğlu, Çekdar Vakıf; Özalp, Veli Cengiz; Borsa, Barı Ata; Soraru, Gian Domenico; 03.09. Department of Materials Science and Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    The authors regret to inform that The TMTVS ratios for samples were written incorrectly. The true weight ratios for PHMS/LDH/PDMS/TMTVS blends should be as follows: Bio1 = 1/0.055/0.25/0.055, and Bio2 = 1/0.055/1/0.055. The discussion in the study is not affected by this mistype and actually the previous paper [1] cited also in the paper as ref.#44 gives right values for the sample preparation. The authors would like to apologize for the inconvenience caused.