Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Author: search.filters.author.Akdoğan, YaşarPublisher: search.filters.publisher.John Wiley and Sons Inc.

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  • Article
    Citation - WoS: 17
    Citation - Scopus: 18
    Development of an Ionic Liquid Based Method for the Preparation of Albumin Nanoparticles
    (John Wiley and Sons Inc., 2018) Demirkurt, Begüm; Akdoğan, Yaşar; Akdoğan, Yaşar; 03.09. Department of Materials Science and Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Albumin based nanocarriers have been widely used in drug delivery studies. Here, we developed a water-in-ionic liquid (IL) emulsion-like method to prepare bovine serum albumin (BSA) nanoparticles as alternative to the traditional organic solvents containing techniques. Conformational changes of albumin induced by the imidazolium based ILs at the water-IL interface triggers the BSA nanoparticle formation. The albumin nanoparticle formation are dependent on the experimental parameters and the hydophobicity of the IL. At pH 9.0, using 1.3%wt of BSA in water/1-butyl-3-methyl imidazolium tetrafluoroborate (BmimBF4) (50/50 mol%) and TX-100/butanol surfactant mixture yields uniformly distributed 200 nm average sized BSA nanoparticles. Different than BmimBF4, using a more hydrophilic IL, EmimBF4 yielded albumin aggregates. Instead, using a more hydrophobic IL, HmimBF4 produced albumin nanoparticles but a non-uniform size distribution was obtained. These results indicate that the ionic liquids called green and designer solvents can be also used to synthesize albumin nanoparticles.
  • Article
    Citation - WoS: 58
    Citation - Scopus: 86
    Intrinsic Surface-Drying Properties of Bioadhesive Proteins
    (John Wiley and Sons Inc., 2014) Akdoğan, Yaşar; Akdoğan, Yaşar; Huang, Kuo-Ying; Kageyama, Yoshiyuki; Danner, Eric W.; Miller, Dusty R.; Martinez Rodriguez, Nadine R.; Waite, J. Herbert; Han, Songi; 03.09. Department of Materials Science and Engineering; 03. Faculty of Engineering; 01. Izmir Institute of Technology
    Sessile marine mussels must "dry" underwater surfaces before adhering to them. Synthetic adhesives have yet to overcome this fundamental challenge. Previous studies of bioinspired adhesion have largely been performed under applied compressive forces, but such studies are poor predictors of the ability of an adhesive to spontaneously penetrate surface hydration layers. In a force-free approach to measuring molecular-level interaction through surface-water diffusivity, different mussel foot proteins were found to have different abilities to evict hydration layers from surfaces - a necessary step for adsorption and adhesion. It was anticipated that DOPA would mediate dehydration owing to its efficacy in bioinspired wet adhesion. Instead, hydrophobic side chains were found to be a critical component for protein-surface intimacy. This direct measurement of interfacial water dynamics during force-free adsorptive interactions at solid surfaces offers guidance for the engineering of wet adhesives and coatings. Home and dry underwater: Repulsive hydration forces hinder wet adhesion in the absence of applied external forces. The direct measurement of hydration-water dynamics by NMR relaxometry at 10 GHz revealed that the most hydrophobic mussel adhesive protein, and not the most enriched with 3,4-dihydroxyphenylalanine, effectively dries the surface and overcomes repulsive hydration forces to adsorb spontaneously to surfaces in preparation for adhesion.