Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Author: search.filters.author.Alsoy Altınkaya, SacideSubject: search.filters.subject.Copolymers

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  • Article
    Citation - WoS: 17
    Citation - Scopus: 22
    Responsive pentablock copolymers for siRNA delivery
    (Royal Society of Chemistry, 2015) Uz, Metin; Mallapragada, Surya K.; Alsoy Altınkaya, Sacide
    In this study, temperature and pH responsive cationic and amphiphilic pentablock copolymers, which consist of the temperature responsive triblock Pluronic F127 sandwiched between pH responsive PDEAEM (poly(2-diethylaminoethyl methacrylate)) end blocks, were used for the first time in the development of polyplex and gold nanoparticle (AuNP) based multicomponent siRNA delivery systems (MCSs). Copolymers in both systems protected siRNA from external effects, provided cell entry and endosomal escape. The thermoreversible micellization of the hydrophobic PPO block facilitated the cellular entry while the PDEAEM blocks enhanced the endosomal escape through protonated tertiary amine groups by pH buffering. The synergistic advantages of the different blocks showed an enhanced effect in the MCSs due to attachment and surface configuration reasons. The siRNA transfection efficiency of MCSs against luciferase expressing SKOV3 cells was 15% higher than both the polyplexes alone and the commercial siRNA transfection agent Lipofectamine RNAiMax at the same applied dose, without any toxicity. The results indicated that the multicomponent systems based on the responsive cationic pentablock copolymers and gold nanoparticles have promising potential as an efficient siRNA delivery vector for future applications.
  • Article
    Citation - WoS: 6
    Citation - Scopus: 7
    Solubility and Diffusivity of Methylmethacrylate and Butylacrylate Monomers in a Mma-Ba Copolymer
    (John Wiley and Sons Inc., 2007) Yürekli, Yılmaz; Alsoy Altınkaya, Sacide; Zielinski, John M.
    Mutual diffusion coefficients and sorption isotherms of methyl methacrylate (MMA) and butyl acrylate (BA) monomers in methyl methacrylate-butyl acrylate copolymer (MMA-BA) have been measured by gravimetric sorption. MMA is found to have higher solubility and diffusion rates in the copolymer than BA. Sorption data for MMA were interpreted using classical Flory-Huggins thermodynamic theory with a constant interaction parameter (χ). A modified version of this theory has been applied to correlate the sorption data of BA, which exhibit a temperature and concentration-dependent χ parameter. For MMA, the isotherm data reveal enhanced polymer-solvent interactions with increasing temperature, while for BA the data indicate a drive toward phase separation with increasing temperature. Despite the difference in thermodynamic behavior, both monomers are found to exhibit Fickian diffusion and the diffusivity data are correlated reasonably well with the Vrentas-Duda free volume theory. Some deviation between the free-volume correlation and the experimental data is observed at the lowest temperature and BA concentration examined.