Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 1Citation - Scopus: 1High-Performance Polyether Sulfone (PES) Membranes Modified With Sunflower Seed Shell-Derived Activated Carbon (SSAC)@zif-11 Nanoparticles for Enhanced Antibiotic Removal and Antifouling Properties(Elsevier, 2025) Alafi, Narges Mortazazad; Barzegar, Behrad; Habibi, Rezvan; Aghdasinia, Hassan; Altinkaya, Sacide Alsoy; Barzegar, B.This study investigates the impact of incorporating a novel composite filler on the antibiotic removal efficiency and protein fouling resistance of polyether sulfone (PES) membranes. The filler was synthesized from activated carbon derived from sunflower seed shells (SSAC) and modified with zeolitic imidazolate framework-11 (ZIF-11). The adsorption capacities of the composite for two model antibiotics, tetracycline (TC) and rifampicin (RP), were evaluated. Mixed matrix membranes were fabricated using the phase inversion method with varying SSAC@ZIF11 contents (0.2-1 wt%). The membrane containing 0.8 wt% SSAC@ZIF-11 exhibited improved structural and surface characteristics, including increased porosity, larger pore size, smoother morphology, and enhanced hydrophilicity, as reflected by a reduction in contact angle from 60.72 degrees to 46.45 degrees. At this optimal loading, the pure water flux increased significantly from 10.52 to 39.1 L/m2h. Moreover, the modified membrane demonstrated outstanding removal efficiencies for TC (99.12 %) and RP (89.9 %), alongside excellent antifouling performance, as indicated by a flux recovery ratio increase from 42.85 % to 99.74 %. These results confirm the potential of SSAC@ZIF-11 as an effective nanofiller for developing high-performance PES membranes in advanced water purification applications.Article Citation - WoS: 7Citation - Scopus: 7Development of a Dopamine-Based Surface Modification Technique To Enhance Protein Fouling Resistance in Commercial Ultrafiltration Membranes(Elsevier, 2025) Onuk, Ecem; Gungormus, Elif; Cihanoglu, Aydin; Altinkaya, Sacide AlsoyThis study introduces a new method for modifying ultrafiltration membranes using dopamine polymerization to overcome issues such as prolonged polymerization times, potential pore narrowing, and insufficient formation of hydrophilic groups. The technique involves continuously supplying oxygen (O2) gas from the porous backside of the membrane while simultaneously applying an aqueous dopamine solution to the active top surface. TGA and XPS analyses revealed that 10 kDa commercial polysulfone (PSF) membranes coated with O2 backflow contained more dopamine than those modified using the classical method. Additionally, changes in contact angle and zeta potential values were more pronounced with the O2 backflow method. Dopamine coating for 10 and 20 min improved the pure water permeance of the PSF membrane, whereas a 40-min coating decreased it. Notably, the reduction in permeance was 2.5 times less with the O2 backflow method than with the classical method. The classical dopamine coating method did not enhance the PSF membrane's resistance to fouling during whey filtration; in fact, 20 and 40-min coatings caused more significant flux declines compared to the unmodified membrane. Conversely, 10 and 20 min of PDA coating under O2 backflow improved fouling resistance, though this benefit disappeared with a 40-min coating.Article Citation - WoS: 1Comparison of Cell-Penetrating and Fusogenic Tat-Ha2 Peptide Performance in Peptideplex, Multicomponent, and Conjugate Sirna Delivery Systems(Amer Chemical Soc, 2024) Uz, Metin; Bulmus, Volga; Altinkaya, Sacide AlsoyIn this study, the performance of the cell-penetrating and fusogenic peptide, TAT-HA2, which consists of a cell-permeable HIV trans-activator of transcription (TAT) protein transduction domain and a pH-responsive influenza A virus hemagglutinin protein (HA2) domain, was comparatively evaluated for the first time in peptideplex, multicomponent, and conjugate siRNA delivery systems. TAT-HA2 in all three systems protected siRNA from degradation, except in the conjugate system with a low Peptide/siRNA ratio. The synergistic effect of different peptide domains enhanced the transfection efficiency of multicomponent and conjugate systems compared to that of peptideplexes, which was attributed to the surface configuration of TAT-HA2 peptides depending on the nature of attachment. Particularly, the multicomponent system showed better cellular uptake and endosomal escape than the peptideplexes, resulting in enhanced siRNA delivery in the cytoplasm. In addition, the presence of cleavable disulfide bonds in multicomponent and conjugate systems promoted the effective siRNA delivery in the cytoplasm, resulting in improved gene silencing activity. The multicomponent system reduced the level of luciferase expression in SKOV3 cells to 45% (+/- 4). In contrast, the conjugate system and the commercially available siRNA transfection agent, Lipofectamine RNAiMax, caused luciferase suppression down to 55% (+/- 2) at a siRNA dose of 100 nM. For the same dose, the peptideplex system could only reduce the luciferase expression to 65% (+/- 5). None of the developed systems showed significant toxicity at any dose. Overall, the TAT-HA2 peptide is promising as a siRNA delivery vector; however, its performance depends on the nature of attachment and, as a result, its surface configuration on the developed delivery system.Article Citation - WoS: 4Citation - Scopus: 5Enhanced Performance and Anti-Fouling Properties of Polyether Sulfone (pes) Membranes Modified With Pistachio Shell-Derived Activated Carbon (psac)@zif-8&zif To Remove Dye Contaminants(Elsevier, 2024) Shakeri, Neda; Barzegar, Behrad; Habibi, Rezvan; Aghdasinia, Hassan; Altinkaya, Sacide AlsoyThis study aims to improve the properties of polyether sulfone (PES) membranes by using an innovative composite filler. Pistachio shell-derived activated carbon (PSAC) was initially synthesized via chemical activation, followed by surface modification with ZIF-8 and ZIF-67. Subsequently, modified membranes with varying weight percentages of this composite were fabricated using the phase inversion method. The PSAC@ZIF-8&ZIF-67/PES membranes were characterized through FESEM, AFM, pore size, zeta potential, porosity, and water contact angle analyses. The incorporation of the composite in the membranes was confirmed through ATR-FTIR, XRD, and EDS mapping analyses. The finding indicated that adding 0.6 wt% of nanoparticles improved membrane hydrophilicity, increased surface charge, and enhanced porosity. Additionally, the mixed membranes exhibited reduced sedimentation and higher dye removal than unmodified membranes. The optimum amount of composite is determined as 0.6 wt%. At this condition, pure water flux (PWF) increased dramatically from 22.56 L/m2h to 96.26 L/m2h. The mixed matrix membrane demonstrated superior efficiency in removing malachite green (MG) (97 %) and crystal violet (CV) dyes (93 %) and achieved the highest recovery ratio of 61.9 %, indicating a more remarkable membrane ability to combat fouling. The developed membrane demonstrated enhanced hydrophilicity, dye removal efficiency, and antifouling properties, making it promising for environmental applications.