Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Author: search.filters.author.Bayraktar, O.

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  • Article
    Integrating QSAR Analysis and Machine Learning To Explore the Antidiabetic Potential of Natural Compounds
    (AMG Transcend Association, 2025) Sincar, B.; Yalcin, D.; Bayraktar, O.
    This study explores the antidiabetic potential of 72 natural compounds using molecular descriptors and QSAR modeling combined with machine learning techniques. The dataset includes 11 experimentally obtained compounds and 61 from the literature, characterized by their IC50 values indicating 50% inhibition of α-glucosidase enzyme activity. Molecular descriptors were generated using ChemAxon’s MarvinSketch and PADEL software, narrowing down over 3000 descriptors to 23 relevant features. Statistical analysis revealed significant multicollinearity among variables, necessitating the application of non-linear machine learning models, namely Random Forest and Gradient Boosting. These models demonstrated predictive capabilities with R² values of 0.7751 and 0.8066, respectively, and highlighted molecular weight and the number of heteroatoms in ring structures as critical features influencing IC50 values. Despite the dataset's variability and limited size, the study underscores the potential of integrating QSAR and machine learning approaches to effectively predict the antidiabetic activity of natural compounds. The findings provide valuable insights for advancing computational methods in drug discovery. © 2025 by the authors.
  • Article
    Citation - WoS: 35
    Citation - Scopus: 40
    Olive Leaf Extract as a Crosslinking Agent for the Preparation of Electrospun Zein Fibers
    (John Wiley and Sons Inc., 2015) Erdogan, I.; Demir, M.; Bayraktar, O.
    Incorporating active agents, reinforcing structure by crosslinking, thus changing release properties, can be listed as possible modifications in preparation methods of biopolymer fibers. This study introduces oleuropein, major component of olive leaf extract (OLE), as a natural functional crosslinker for electrospun zein fibers, owing to its antioxidant and antimicrobial properties. Incorporation of OLE causes morphological and structural changes indicated by a decrease in fiber diameter up to 27%, an increase in intensity of NH bending region due to interaction with -OH groups and observation of characteristic oleuropein bands. Extract addition also enhances thermal stability. Zein fibers without OLE is fully degraded at 600C, whereas 10% of OLE loaded zein fibers is left undegraded. Fifty percent of initial phenolic content loaded into fibers is released which indicate the effect of OLE incorporation as accumulation of oleuropein. OLE-incorporated fibers immersed in PBS are less fused than pure zein fibers, due to the crosslinking effect. © 2014 Wiley Periodicals, Inc.