Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Author: search.filters.author.Boyacı, EzelInstitution Author: search.filters.institutionAuthor.Ölçer, Yekta Arya

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  • Article
    Citation - WoS: 1
    Citation - Scopus: 2
    A Molecularly Imprinted Polymer as Solid Phase Extraction Sorbent for Ketoprofen Determination in Water and Artificial Serum Prior To Hplc
    (TÜBİTAK - Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, 2022) Shahwan, Talal; Gürel Özyurt, Elif; Shahwan, Talal; Ölçer, Yekta Arya; Eroğlu, Ahmet Emin; Eroğlu, Ahmet Emin; 04.01. Department of Chemistry; 04. Faculty of Science; 01. Izmir Institute of Technology
    Ketoprofen (KET) is an active pharmaceutical compound that has pain relieving and antipyretic effects. Its determination in body fluids and environmental waters is important due to widespread use of the compound. In this study, a selective and reliable method has been developed for the determination of ketoprofen in water and artificial serum using molecularly imprinted polymers (MIPs) as a solid phase extraction sorbent prior to HPLC-DAD detection. The MIP was synthesized by copolymerization of methacrylic acid (MAA) and trimethylpropane trimethacrylate (TRIM) in the presence of ketoprofen as the template. For the sake of comparison, nonimprinted polymer (NIP) was also synthesized under the same experimental conditions without the addition of ketoprofen under the same experimental conditions. Critical extraction parameters such as sample pH, shaking time and sorbent amount were optimized and adjusted to 8.0, 24 h, and 10.0 mg, respectively, for a sample volume of 10.0 mL. MIP showed higher selectivity than NIP towards ketoprofen in an artificial matrix containing another pain relieving drug, ibuprofen, and a cardiovascular drug, metoprolol. The proposed method was successfully applied for the detection of ketoprofen in spiked drinking water, tap water, and artificial serum samples, and showed satisfactory results with respective recoveries of 96.8 % (± 0.8), 93.7% (± 0.6), 62.2% (± 0.6), and 69.9% (± 0.6).
  • Article
    Citation - WoS: 169
    Citation - Scopus: 177
    Thin Film Microextraction: Towards Faster and More Sensitive Microextraction
    (Elsevier Ltd., 2019) Ölçer, Yekta Arya; Eroğlu, Ahmet Emin; Tascon, Marcos; Eroğlu, Ahmet Emin; Boyacı, Ezel; 04.01. Department of Chemistry; 04. Faculty of Science; 01. Izmir Institute of Technology
    Thin film microextraction (TFME) is an analytical tool that has been proven to be suitable for integrated sampling and sample preparation of a wide variety of routine and on-site applications. Compared to the traditional microextraction techniques, the most important advantage of TFME is its enhanced sensitivity due to the relatively larger extractive phase spread over a larger surface area. The technique, in this way, facilitates fast extraction kinetics and high extractive capacity. Moreover, TFME offers high versatility for device development over classical SPME technologies due to the plethora of available extractive phases, coating methods and geometry options. The goal of this review is to provide a comprehensive summary of the contemporary advances in this exciting field covering novel extractive phases, technological and methodological developments, and relevant cutting-edge applications. Finally, a critical discussion of the future trends on TFME is also presented. (C) 2019 Elsevier B.V. All rights reserved.