Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Task-Specific Dynamical Entropy Variations in EEG as a Biomarker for Parkinson's Disease Progression(Springer, 2025) Onay, Fatih; Karacali, BilgeUncovering the neuronal mechanisms un-derlying optimal behavioral performance is essential to understand how the brain dynamically adapts to changing conditions. In Parkinson's disease (PD), these neuronal mechanisms are disrupted and lead to impairments in motor coordination and higher-order cognitive functions. This study investigates neuronal dynamics during a lower-limb pedaling task by analyzing the dynamical entropy of EEG signals in healthy controls (HC), PD patients, and PD patients with freezing of gait (PDFOG). We examined both average entropy changes and entropy variability across trials to characterize task-specific neural adaptations across disease progression. Results showed that PD and PDFOG patients exhibited decreased levels of permutation entropy in frontal and parietal regions, which may be associated with loss of cognitive adapta-tion due to altered information processing. Additionally, Vasicek's entropy variability in both PD groups was significantly diminished in occipital and left frontal regions, suggesting reduced cognitive capacity to dy-namically allocate neuronal resources during task engagement. We extended this analysis to the classification of groups using LDA and SVM classifiers, where entropy-derived features achieved a classification accuracy of up to 96.15% when distinguishing HC from PDFOG patients. This dynamical entropic framework provides a novel approach for capturing neural complexity changes during task performance, revealing subtle cognitive-motor impairments in PD. Understanding the maintenance of cognitive information processing and flexibility in response to motor and cognitive task demands could be a useful tool to track PD diagnosis and progression in addition to resting-state analyses.Conference Object Citation - Scopus: 3Entropik Kümeleme Kullanılarak Beyin Aktivitesi Karakterizasyonu(IEEE, 2017) Olcay, Bilal Orkan; Karacali, Bilge; Ozgoren, Murat; Guducu, CagdaIn this study, two novel entropy and mutual information based algorithms have been proposed to characterize the stimulus specific brain activity. In the first method, inter channel mutual information of electroencephalography signals has been calculated and the channels that exhibit synchronized behaivour during stimulus. In the second method, the responsiveness of the individual channels has been characterized in an entropic manner and then, the channels which demonstrates stimulus specific entropic behavior have been obtained. The performance of the proposed methods has been simulated on a real dataset obtained from Dokuz Eylul University Brain Biophysics laboratory. The results demonstrate that different regions of the brain exhibit a coherent activity during stimulus.