Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
Browse
5 results
Search Results
Article Citation - WoS: 7Citation - Scopus: 6Polymeric Biomaterials for Periodontal Tissue Engineering and Periodontitis(Royal Soc Chemistry, 2024) Yuruk, Gizem; Demir, Yagmur Damla; Vural, Sevra; Kehr, Nermin SedaThe periodontium is one of the most complex tissues in the body because its structure is formed by a hierarchical combination of soft and hard tissues. Due to its complex architecture, the treatment and regeneration of damaged periodontal tissue caused by diseases is still a challenge in biomedicine. The most common disease of the periodontium is periodontitis, which occurs when the periodontium becomes infected and inflamed as a bacterial biofilm forms in the mouth. Recently, various biocompatible biomaterials made of natural and synthetic polymers have been developed for periodontal tissue regeneration or treatment due to their superior properties such as controlled drug and bioactive molecule delivery, mimicking the 3D network of tissue, biocompatibility, antibacterial and mechanical properties. In particular, biomaterials designed for drug delivery, such as hydrogels, scaffolds, films, membranes, micro/nanoparticles and fibers, and additively manufactured biomaterials have undergone in vitro and in vivo testing to confirm their potential clinical utility in periodontal regeneration and periodontitis treatment. This review explores recent advances in the use of biomaterials for the prevention and/or treatment of periodontal regeneration and periodontitis. Specifically, it emphasizes advancements in drug/biomolecule delivery and the use of additively manufactured biomaterials for addressing periodontal issues.Article Citation - WoS: 3Citation - Scopus: 3The Effect of Co-Delivery of Oxygen and Anticancer Drugs on the Viability of Healthy and Cancer Cells Under Normoxic and Hypoxic Conditions(Wiley-v C H verlag Gmbh, 2024) Kehr, Nermin SedaHypoxia, cancer, tissue damage, and acidic pH conditions are interrelated, as chronic hypoxic conditions enhance the malignant phenotype of cancer cells, causing more aggressive tissue destruction, and hypoxic cells rely on anaerobic glycolysis, leading to the accumulation of lactic acid. Therefore, the administration of oxygen is necessary to support the functions of healthy cells until the formation of new blood vessels and to increase the oxygen supply to cancerous tissues to improve the efficacy of antitumor drugs on tumor cells. In addition to O2 supply, pH-dependent delivery of anticancer drugs is desired to target cancer cells and reduce drug side effects on healthy cells. However, the simultaneous delivery of O2 and pH-dependent anticancer drugs via nanomaterials and their effects on the viability of normal and cancer cells under hypoxic conditions have not been studied in sufficient numbers. This study describes the synthesis of a pH-responsive nanomaterial containing oxygen and anticancer drugs that exhibits sustained O2 release over a 14 d period under hypoxic conditions and pH-dependent sustained release of anticancer drugs over 30 d. The simultaneous administration of O2 and anticancer drugs results in higher cell survival of normal cells than that of cancer cells under hypoxic and normoxic conditions. The synthesis of pH-sensitive perfluorocarbon-based nanomaterials containing oxygen and anticancer drugs is reported. These nanomaterials provide oxygen release within 14 d and pH-dependent sustained release of anticancer drugs over 30 d. Co-delivery of oxygen and anticancer drugs by pH-sensitive nanomaterials promotes the viability of healthy cells compared to malignant cells under hypoxic conditions. imageArticle Citation - WoS: 3Citation - Scopus: 3Roadmap on Multifunctional Materials for Drug Delivery(IOP Publishing, 2024) Nottelet, Benjamin; Buwalda, Sytze; van Nostrum, Cornelus F.; Zhao, Xiaofei; Deng, Chao; Zhong, Zhiyuan; Cheah, Ernest; Kehr, Nermin SedaThis Roadmap on drug delivery aims to cover some of the most recent advances in the field of materials for drug delivery systems (DDSs) and emphasizes the role that multifunctional materials play in advancing the performance of modern DDSs in the context of the most current challenges presented. The Roadmap is comprised of multiple sections, each of which introduces the status of the field, the current and future challenges faced, and a perspective of the required advances necessary for biomaterial science to tackle these challenges. It is our hope that this collective vision will contribute to the initiation of conversation and collaboration across all areas of multifunctional materials for DDSs. We stress that this article is not meant to be a fully comprehensive review but rather an up-to-date snapshot of different areas of research, with a minimal number of references that focus upon the very latest research developments.Review Citation - WoS: 13Citation - Scopus: 13Oxygen Delivery Biomaterials in Wound Healing Applications(WILEY-V C H VERLAG GMBH, 2023) Bayraktar, Sema; Üstün, Cansu; Kehr, Nermin SedaOxygen (O2) delivery biomaterials have attracted great interest in the treatment of chronic wounds due to their potential applications in local and continuous O2 generation and delivery, improving cell viability until vascularization occurs, promoting structural growth of new blood vessels, simulating collagen synthesis, killing bacteria and reducing hypoxia-induced tissue damage. Therefore, different types of O2 delivery biomaterials including thin polymer films, fibers, hydrogels, or nanocomposite hydrogels have been developed to provide controlled, sufficient and long-lasting O2 to prevent hypoxia and maintain cell viability until the engineered tissue is vascularized by the host system. These biomaterials are made by various approaches, such as encapsulating O2 releasing molecules into hydrogels, polymer microspheres and 3D printed hydrogel scaffolds and adsorbing O2 carrying reagents into polymer films of fibers. In this article, different O2 generating sources such as solid inorganic peroxides, liquid peroxides, and photosynthetic microalgae, and O2 carrying perfluorocarbons and hemoglobin are presented and the applications of O2 delivery biomaterials in promoting wound healing are discussed. Furthermore, challenges encountered and future perspectives are highlighted. Oxygen delivery (O2) biomaterials have attracted great interest in the treatment of chronic wounds due to their ability to continuously deliver oxygen and support cell viability. Therefore, various O2 generating sources such as solid inorganic peroxides, liquid peroxides and photosynthetic microalgae, and O2-carrying perfluorocarbons and hemoglobin are incorporated into different biomaterial networks for wound healing applications.imageReview Citation - WoS: 116Citation - Scopus: 125Salivary Biomarkers: Novel Noninvasive Tools To Diagnose Chronic Inflammation(Springer, 2023) Dongiovanni, Paola; Meroni, Marica; Casati, Sara; Goldoni, Riccardo; Thomaz, Douglas Vieira; Kehr, Nermin Seda; Galimberti, DanielaSeveral chronic disorders including type 2 diabetes (T2D), obesity, heart disease and cancer are preceded by a state of chronic low-grade inflammation. Biomarkers for the early assessment of chronic disorders encompass acute phase proteins (APP), cytokines and chemokines, pro-inflammatory enzymes, lipids and oxidative stress mediators. These substances enter saliva through the blood flow and, in some cases, there is a close relation between their salivary and serum concentration. Saliva can be easily collected and stored with non-invasive and cost-saving procedures, and it is emerging the concept to use it for the detection of inflammatory biomarkers. To this purpose, the present review aims to discuss the advantages and challenges of using standard and cutting-edge techniques to discover salivary biomarkers which may be used in diagnosis/therapy of several chronic diseases with inflammatory consequences with the pursuit to possibly replace conventional paths with detectable soluble mediators in saliva. Specifically, the review describes the procedures used for saliva collection, the standard approaches for the measurement of salivary biomarkers and the novel methodological strategies such as biosensors to improve the quality of care for chronically affected patients.