Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 6Citation - Scopus: 7A Comprehensive Study on Doxorubicin-Loaded Aspartic Acid-Coated Magnetic Fe<sub>3</Sub>o<sub>4< Nanoparticles: Synthesis, Characterization and in Vitro Anticancer Investigations(Elsevier, 2024) Jafari, Nahideh; Mohammadpourfard, Mousa; Hamishehkar, HamedMagnetic Fe3O4 nanoparticles (MNPs) hold significant potential across various scientific fields due to their notable properties. For biomedical applications, MNPs must be biocompatible, stable, and possess high magnetic potential. Aspartic acid (ASP) as a coating agent not only provides biocompatibility, stability, and high magnetic potential but also offers the potential for absorbing various drugs for targeted delivery due to its carboxyl and amino functional groups. So, in this study, we synthesized ASP-coated MNPs (ASP-MNPs) through a one-step co-precipitation method and loaded doxorubicin (DOX) onto these nanoparticles to create DOX-ASP-MNPs for targeted drug delivery. Characterization of the nanoparticle confirmed the crystal structure, spherical morphology, and improved size distribution of ASP-MNPs (8.53 +/- 2.56 nm) compared to uncoated MNPs (7.05 +/- 1.89 nm), as analyzed by XRD, FESEM, and TEM. FT-IR and zeta potential assessments (ZP = -6.3 mV for MNPs, ZP = -31.1 mV for ASP-MNPs) verified successful ASP binding, DOX loading, and nanoparticle stability. VSM analysis indicated a slight decrease in saturation magnetism after coating (51.1 emu/g) compared to MNPs (57.4 emu/g). In vitro release studies demonstrated a higher release rate (83 %) of DOX-ASP-MNPs at pH 5.2, indicating their suitability for cancerous cells. Cytotoxicity assays on A-549 cancer cell lines showed a dose-dependent response. DAPI staining revealed that free DOX caused more DNA damage. Cellular uptake studies indicated a time-dependent uptake of DOX-ASP-MNPs, higher at 3 h compared to 1 h, though lower than free DOX uptake due to different uptake pathways. Apoptosis assays over 72 h showed similar apoptotic rates for DOX-ASP-MNPs and free DOX. These findings suggest that ASP-MNPs possess enhanced physicochemical properties and effective drug delivery capabilities, making them a promising candidate for different biomedical applications, particularly targeted cancer therapy.Article Citation - WoS: 4Citation - Scopus: 5A Smart Building Energy Management Incorporating Clustering-Based Tariffs in the Presence of Domestic Solar Energy, Battery, and Electric Vehicle(Pergamon-elsevier Science Ltd, 2024) Alilou, Masoud; Mohammadi-ivatloo, Behnam; Mohammadpourfard, MousaSmart buildings play a crucial role in optimizing energy management within the power network. As end-users of the power network, they have the ability to not only reduce economic costs for householders but also modify the technical indices of the power network. To promote efficient device management in smart homes (SH), demand response programs are recommended for consumers. This research investigates the application of clusteringbased electricity pricing strategy aimed at effectively managing the energy devices of a residential smart home. The utilized method categorizes the electricity tariff into five rates according to the clustering of the realtime pricing program. Ward's clustering method is utilized to cluster and determine new electricity tariffs. The primary goal of the energy management program is to minimize the building's energy cost, which is accomplished through the utilization of the multi-verse optimizer. The smart home consists of essential and manageable appliances, a photovoltaic panel (PV), a sodium-sulfur (NaS) battery, and an electric vehicle (EV). The initial parameters of the PV and EV are modeled stochastically by their probability distribution functions and calculated using the Latin hypercube sampling algorithm. The smart building's performance is assessed by taking into account various demand response programs. The numerical results present that the application of the clusteringbased management method has resulted in a significant reduction of 23-43 % in the electricity cost of smart homes. Additionally, the smart home exhibits a more linear consumption pattern when considering the electricity tariffs based on the clustering approach.Article Citation - WoS: 10Citation - Scopus: 12Bimetallic Mof@cds Nanorod Composite for Highly Efficient Piezo-Photocatalytic Co2 Methanation Under Visible Light(Elsevier Sci Ltd, 2024) Farshchi, Mahdi Ebrahimi; Asgharizadeh, Kimia; Jalili, Hadi; Nejatbakhsh, Siyamak; Azimi, Babak; Aghdasinia, Hassan; Mohammadpourfard, MousaCO2 methanation is leading progress in both dwindling the emitted greenhouse gas and taking advantage of CO2 conversion to a worthwhile fuel. Various types of catalysts have gained researchers' attention. On the other hand, those catalysts chiefly suffer from being uneconomical, owning laborious processes, and having low efficiency. Particularly in the photocatalytic process, electron-hole recombination, charge separation efficiency, and the photocorrosion are the most remarkable obstacles in the path of gaining high efficiency. To conquer the aforementioned hindrances, Cu/Zr-MOF@CdS had been designed in order to not only do elevate CH4 selectivity but also increase CO2 conversion by altering the electron transfer mechanism. Doping Cu in Zr-MOF structure restrains C-C coupling and ameliorates the viability of protonation of *CO to *HCO during methane production. CdS and Zr-MOF both grant piezoelectricity trait to the catalyst in a way that by merging it with the photocatalytic process the mechanism of process converted from type (II) scheme to Z-scheme, culminating in thwarting recombination and increase of charge separation efficiency. The photocatalytic process achieved 23.6 mu mol. g- 1. h- 1 CH4 reaction rate and 80 % CO2 conversion, hereafter applying the piezo-photocatalytic process, these two factors reached 52.2 mu mol. g- 1. h- 1 and 99 %, respectively. This work unveils the viable reaction routes along with their several quotas in piezo-photocatalytic CO2 methanation process by scrutinizing the intricate mechanisms via in-situ analyses.Article Citation - WoS: 22Citation - Scopus: 24Design, Evaluation, and Optimization of an Integrated Proton Exchange Membrane and Double Flash Geothermal Based Organic Rankine Cycle Multi-Generation System Fed by a Biomass-Fueled Gasifier(Elsevier, 2024) Taheri, Muhammad Hadi; Seker, Utku; Akkurt, Gulden Gokcen; Mohammadpourfard, MousaThis study introduces an innovative approach by formulating and evaluating a synergistic biomass-geothermal structure, emphasizing optimized inter-component connections. The research stands out for its thorough analysis of parameter impacts on the system and variables, addressing an unexplored aspect in integrated energy systems. The multi-generation systems are the integration of a combined gasification gas turbine cycle, double flash geothermal cycle, and proton exchange membrane cycle for the generating power and hydrogen. The overall system and its subsystems are studied to explore how the performance of thermodynamics and the total cost rate are influenced by operating parameters. The best operational conditions for both subsystems and the overall system have been determined by analyzing the impact of operating parameters on the thermodynamic behavior and environmental impact through parametric studies. The findings indicate while Sabalan's current efficiency is 16.26 %, the system energy efficiency reached 24.89 % when coupled with other renewable source. To enhance the system's efficiency, a genetics algorithm was utilized to simultaneously optimize the total cost of exergy destruction and investment cost. The outcome of the multi-objective optimization revealed that the exergy efficiency of optimal point for the system is 29.8 % and a total investment cost is 6 (M$/year).Article Citation - WoS: 13Citation - Scopus: 13The Influence of Nano Filter Elements on Pressure Drop and Pollutant Elimination Efficiency in Town Border Stations(Nature Portfolio, 2023) Ebadiyan, Hamed; Heris, Saeed Zeinali; Mousavi, Seyed Borhan; Nami, Shamin Hosseini; Mohammadpourfard, MousaNatural gas stands as the most ecologically sustainable fossil fuel, constituting nearly 25% of worldwide primary energy utilization and experiencing rapid expansion. This article offers an extensive comparative analysis of nano filter elements, focusing on pressure drop and pollutant removal efficiency. The primary goal was to assess the superior performance of nano filter elements and their suitability as an alternative for Town Border Station (TBS). The research encompassed a six-month examination period, involving routine pressure assessments, structural examinations, and particle characterization of the filter elements. The results revealed that nano filters showed better performance in adsorbing aluminum than conventional filters, possibly due to their cartridge composition. Nano filters contained phosphorus, sulfur, and copper, while conventional filters lacked these elements. The disparity can be attributed to the finer mesh of the nano filter, capturing smaller pollutants. Although the nano filter had minimal silicon, the conventional filter showed some, posing concerns. Despite having 19 extra pleats, the nano filter maintained gas flow pressure while capturing more particles than the conventional filter.