Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Author: search.filters.author.Vakifahmetoglu, CekdarPublisher: search.filters.publisher.Wiley

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  • Article
    Enhanced Doxorubicin Cytotoxicity on Breast Cancer Spheroids by Aptamer Targeted Co-Delivery With Hyaluronidase
    (Wiley, 2025) Kavruk, Murat; Demirel, Dide Su; Bonyadi, Farzaneh; Guner, Buket Cakmak; Dursun, Ali Dogan; Vakifahmetoglu, Cekdar; Ozalp, Veli Cengiz
    Breast cancer is one of the most prevalent solid tumors in women and can be classified into subtypes based on molecular characteristics, such as hormone receptor status and HER2 expression. Aptamers, highly specific affinity molecules, are extensively studied for targeted drug delivery using nanocarriers to enhance anti-cancer efficacy. This study focused on HER2-responsive co-delivery of doxorubicin and hyaluronidase via aptamer-gated mesoporous silica nanoparticles to improve therapeutic outcomes in solid tumors. SK-BR-3 spheroids are employed as a model for resistant tumor environments in solid tumors. Previous research is shown that conjugating cytotoxic drugs with nanoparticles or cells enhances drug penetration into tumor spheroids. In this work, doxorubicin is loaded into mesoporous silica nanoparticles and capped with HER2-specific aptamers, while the particle surface is functionalized with hyaluronidase. This dual-functionalized nanocarrier system achieves an approximate to 8.5-fold increase in cytotoxicity compared to aptamer-targeted delivery lacking hyaluronidase. The enhanced effect is attributed to hyaluronidase-mediated loosening of the spheroid structure, facilitating nanoparticle penetration and localized release of doxorubicin at high concentrations on HER2-positive cells.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 5
    Sioc Foam-Aerogel Composites: Optimal Balance of Lightness and Excellent Thermal Insulation
    (Wiley, 2024) Icin, Oyku; Abebe, Adane Muche; Soraru, Gian Domenico; Vakifahmetoglu, Cekdar
    Foam-aerogel composites are synthesized in polymeric, hybrid, and ceramic states by completing the open cells of the foam with a solution forming a wet gel, carbon dioxide (CO2) supercritically dried, and pyrolyzed. Thermal diffusivity measurements are conducted using the laser flash, and for mechanical performance, cold crushing tests are done to obtain compressive strengths. Samples possess a range of specific surface area (SSA) values up to similar to 650 m2/g contingent upon the material state, that is, polymeric, hybrid, or ceramic. While SSA values can be deliberately altered, almost all samples demonstrated a total porosity of similar to 90 vol%, with superb specific compressive strength reaching around 2 MPa. In addition to adjustable surface characteristics granting hydrophobic and hydrophilic features, the study revealed the potential use of these foam-aerogel composites as thermal insulators with low thermal conductivities of 0.02 W<middle dot>m-1<middle dot>K-1 at RT and 0.05 W<middle dot>m-1<middle dot>K-1 at 500 degrees C. When exposed directly to a butane flame gun with a flame temperature reaching similar to 1200 degrees C, from the backside of a 5 mm-thick foam-aerogel composite, only similar to 200 degrees C is recorded, which is lower than a comparable commercial insulator panel tested under the same conditions.