Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Author: search.filters.author.Yaşar Mahlıçlı, FilizPublication Index: search.filters.publicationIndex.PubMed

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  • Article
    Citation - WoS: 29
    Citation - Scopus: 33
    Surface Modification of Polysulfone Based Hemodialysis Membranes With Layer by Layer Self Assembly of Polyethyleneimine/Alginate-heparin: a Simple Polyelectrolyte Blend Approach for Heparin Immobilization
    (Springer Verlag, 2013) Yaşar Mahlıçlı, Filiz; Alsoy Altınkaya, Sacide
    This study intends to improve blood compatibility of polysulfone (PSF) membranes by generating a nonthrombogenic surface through heparin immobilization. To achieve this task, the support membrane prepared from a blend of PSF and sulfonated polysulfone (SPSF) was modified with layer by layer (LBL) deposition of polyethyleneimine (PEI) and alginate (ALG) and heparin blended with ALG was immobilized only on the outermost surface of the LBL assembly. The results have shown that the adsorption of human plasma proteins and platelet activation on the LBL modified membranes decreased significantly compared with the unmodified PSF and PSF-SPSF blend membranes. Furthermore, blending ALG with a small amount of heparin remarkably prolonged the APTT values of heparin free PEI/ALG coated membranes. It is envisaged that the use of a blend of HEP and ALG only in the terminating layer of the LBL assembly can be an economical and alternative modification technique to create nonthrombogenic surfaces.
  • Article
    Citation - WoS: 8
    Citation - Scopus: 8
    The Effects of Urease Immobilization on the Transport Characteristics and Protein Adsorption Capacity of Cellulose Acetate Based Hemodialysis Membranes
    (Springer Verlag, 2009) Yaşar Mahlıçlı, Filiz; Alsoy Altınkaya, Sacide
    In this study, cellulose acetate (CA) based hemodialysis membranes were prepared by a dry phase inversion method and the influences of urease immobilization on the clearing performance and protein adsorption capacity of the membranes were investigated. Permeation experiments have shown that modification of CA membranes with urease immobilization not only enhanced the transport rate of urea but also increased the permeation coefficients of uric acid and creatinine by changing the structure of the membrane. Furthermore, the protein adsorption capacity of the CA membranes decreased. On the other hand, the mechanical strength of the modified CA membrane did not change significantly compared with that of the unmodified one. A mathematical model was derived to determine the rate of mass transfer of urea through modified CA membranes. Model predictions along with the experimental data suggest that urease immobilization can be used as an alternative method in preparing CA based hemodialysis membranes with improved transport characteristics and biocompatibility through reduced protein adsorption capacities.