Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Author: search.filters.author.Yildiz,A.A.

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  • Book Part
    Citation - Scopus: 1
    Utilization of Natural and Synthetic Hydrogels for Biofabrication
    (World Scientific Publishing Co., 2022) Yildiz,B.; Yildiz,A.A.
    Soft materials hold the potential to constitute native like microenvironment and complexity of tissues and organs better than any other counterpart. Advances in soft biomaterials have supported the rapid development of applications in biotechnology and biomedicine. Hydrogel-based soft materials have attracted great interest due to their excellent chemical, physical/biophysical properties, and functionalities suitable for constructing 3D biomaterials. Current developments in biofabrication techniques give the possibility to design novel hydrogel-based biomaterials. We foresee that there is a need to define and classify hydrogel-based natural and synthetic biomaterials for biofabrication applications. In this work, our ultimate purpose is summarizing the utilization of hydrogels in the field of biofabrication in every aspect. First, conventional and advanced biofabrication techniques to construct hydrogel-based biomaterials will be discussed. Second, applications of biofabricated hydrogels in varied fields like tissue engineering, cell culture, and regenerative medicine will be presented. Finally, current challenges and future perspectives in the field of biofabrication of natural and synthetic hydrogels will be exhibited. © 2023 by World Scientific Publishing Co. Pte. Ltd.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 6
    Fabrication of Gelatin-Polyester Based Biocomposite Scaffold Via One-Step Functionalization of Melt Electrowritten Polymer Blends in Aqueous Phase
    (Elsevier B.V., 2024) Köksal,B.; Kartal,R.B.; Günay,U.S.; Durmaz,H.; Yildiz,A.A.; Yildiz,Ü.H.
    The rapid manufacturing of biocomposite scaffold made of saturated-Poly(ε-caprolactone) (PCL) and unsaturated Polyester (PE) blends with gelatin and modified gelatin (NCO-Gel) is demonstrated. Polyester blend-based scaffold are fabricated with and without applying potential in the melt electrowriting system. Notably, the applied potential induces phase separation between PCL and PE and drives the formation of PE rich spots at the interface of electrowritten fibers. The objective of the current study is to control the phase separation between saturated and unsaturated polyesters occurring in the melt electro-writing process and utilization of this phenomenon to improve efficiency of biofunctionalization at the interface of scaffold via Aza-Michael addition reaction. Electron-deficient triple bonds of PE spots on the fibers exhibit good potential for the biofunctionalization via the aza-Michael addition reaction. PE spots are found to be pronounced in which blend compositions are PCL-PE as 90:10 and 75:25 %. The biofunctionalization of scaffold is monitored through C[sbnd]N bond formation appeared at 400 eV via X-ray photoelectron spectroscopy (XPS) and XPS chemical mapping. The described biofunctionalization methodology suggest avoiding use of multi-step chemical modification on additive manufacturing products and thereby rapid prototyping of functional polymer blend based scaffolds with enhanced biocompatibility and preserved mechanical properties. Additionally one-step additive manufacturing method eliminates side effects of toxic solvents and long modification steps during scaffold fabrication. © 2024 Elsevier B.V.