Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

Browse

Filters

2022 - 20242

Settings

Author: search.filters.author.Zeybek, Nuket

Search Results

Now showing 1 - 2 of 2
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    Development of Xylan-Coated Acid-Resistant Micellar Drug Carriers for Colon-Targeted Oral Delivery
    (Taylor & Francis As, 2024) Zeybek, Nuket; Büyükkileci, Ali Oğuz; Polat, Hurriyet; Polat, Hürriyet; Gulec, Sukru; Güleç, Şükrü; Buyukkileci, Ali Oguz; 03.08. Department of Food Engineering; 04.01. Department of Chemistry; 03. Faculty of Engineering; 04. Faculty of Science; 01. Izmir Institute of Technology
    Oral delivery of hydrophobic drugs from the stomach through the colon has some requirements: (1) an acid-resistant carrier (2) a colon-specific drug release mechanism; and (3) an enhanced bioavailability. In this study, curcumin-loaded polymeric micelles with a xylan-based composite coating were designed and developed. For this purpose, a new synthesis method was used to precipitate xylan by concurrent chitosan polymerization at different xylan/chitosan ratios using a negatively charged crosslinking agent, TPP. The study was to provide the stability of the coated micellar structures in the stomach (low pH conditions) and their degradation in the colon (a natural environment of bacteria) to release the drug. It was observed that the coating successfully prevented early drug release up to 85%, depending on the fraction of xylan in the coating. The nanocarriers that first passed through the stomach conditions were incubated with a xylanolytic colonic bacterium (Bacteroides ovatus) to determine the bacterium-related release mechanism, which was around 27%. This shows the colon-specific release expectation of coated nanocarriers in the colon environment, with an additional benefit due to the degradation of xylan and an improvement in the colon environment by prebiotic activity.
  • Book Part
    Citation - Scopus: 3
    Tissue Engineering Applications of Marine-Based Materials
    (Springer, 2022) Polat, Hürriyet; Polat, Hürriyet; Zeybek, Nuket; Polat, Mehmet; Polat, Mehmet; 04.01. Department of Chemistry; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 04. Faculty of Science; 01. Izmir Institute of Technology
    Tissue engineering is a promising approach in replacing or improving tissues lost or has become nonviable due to disease or trauma by the use of scaffold materials by combining engineering and biochemical/physicochemical methods. Its purpose is to create suitable matrices that support cell differentiation and proliferation toward the formation of new and functional tissue. Marine-based natural compounds are potential scaffold feedstock material in tissue engineering owing to their biocompatibility and biodegradability while providing excellent biochemical/physicochemical properties. Numerous application areas and various fabrication routes techniques described in the literature attest to the importance of these materials in tissue regeneration. This review has been carried to merge the information from a large number of studies on the marine-based scaffold materials in tissue engineering into a coherent summary. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.