Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 1Citation - Scopus: 1The Role of Trna Fragments on Neurogenesis Alteration by H2o2-Induced Oxidative Stress(Springernature, 2025) Karacicek, Bilge; Katkat, Esra; Binokay, Leman; Ozhan, Gunes; Karakulah, Goekhan; Genc, SerminTransfer RNAs (tRNAs) are small non-coding RNA molecules transcribed from tRNA genes. tRNAs cleaved into a diverse population tRNA fragments (tRFs) ranging in length from 18 to 40 nucleotides, they interact with RNA binding proteins and influence the stability and translation. Stress is one of the reasons for tRFs cleavage. In our study, we modeled oxidative stress conditions with hydrogen peroxide (H2O2) exposure and dealt with one of the frequently expressed tRF in the hippocampus region of the brain, which is tRF-Glu-CTC. For this purpose, neural stem cells (NSCs) were exposed to H2O2, and tRF-Glu-CTC levels were increased in various H(2)O(2 )concentrations. A decrease was seen in microtubule-associated protein 2 (MAP2) marker expression. To understand the H(2)O(2)oxidative stress condition on the expression of tRNA fragments, 72 hpf zebrafish embryos exposed to different H(2)O(2 )concentrations, an increase in the level of tRF-Glu-CTC was observed in all concentrations of H(2)O(2 )compared to control. Subsequently, neurogenesis markers were figured out via Calb2a (calbindin 2a) in situ hybridization (ISH) and HuC/D immunofluorescence staining (IF) staining experiments. Under H(2)O(2 )exposure, a decline was observed in Calb2a and HuC/D markers. To understand the inhibitory role of tRF-Glu-CTC on neurogenesis, NSCs were transfected via tRF-Glu-CTC inhibitor, and neurogenesis markers (ss III-tubulin, MAP2, and GFAP) were determined with qRT-PCR and IF staining. tRF-Glu-CTC inhibitor reversed the diminished neuronal markers expression under the exposure of H2O2. Gene Ontology (GO) enrichment analysis showed us that targets of tRF-Glu-CTC are generally related to neuronal function and synaptic processes.Article Citation - WoS: 1Citation - Scopus: 1Fractional Duals of the Poisson Process on Time Scales With Applications in Cryptography(Springernature, 2024) Gharari, Fatemeh; Hematpour, Nafiseh; Bakouch, Hassan S.; Popovic, Predrag M.A super-structure system for probability densities, covering not just typical types but also fractional ones, was developed using the time scale theory. From a mathematical point of view, we discover duals of the Poisson process on the time scale T=R\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathbb {T}=\mathbb {R}$$\end{document} for the time scales T=Z\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\mathbb {T}=\mathbb {Z}$$\end{document} and T=qZ,\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ \mathbb {T}=q<^>{\mathbb {Z}},$$\end{document} evaluating del-\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\nabla -$$\end{document}calculus and Delta-\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\Delta -$$\end{document}calculus. Also, we search the fractional extensions of the Poisson process on these time scales and detect duals of them. A simulation allows for comparing the nabla and delta types of the observed distributions, not just typical types but also fractional ones. As an application, we also propose new substitution boxes (S-boxes) using the proposed stochastic models and compare the performance of S-boxes created in this way. Given that the S-box is the core for confusion in Advanced Encryption Standard (AES), the formation of these new S-boxes represents an interesting application of these stochastic models.Article Citation - WoS: 2Citation - Scopus: 4A Study on a Computationally Efficient Controller Design for a Surgical Robotic System(Springernature, 2023) Ayit, Orhan; Dede, Mehmet Ismet CanThe control algorithms of the surgical robotic system using the robot's dynamics produce a relatively high computational load on the processor. This paper develops a computationally efficient computed torque controller by using a simplified dynamic modeling method and implemented in a novel surgical robot experimentally. In addition, an independent joint controller is designed and implemented to compare the results of the computed torque controller.Article Citation - WoS: 1Citation - Scopus: 1Laser Surface Treatment Optimization of 1.2379 (Aisi D2) Tool Steel(Springernature, 2025) Ozbey, Sayit; Artem, Hatice SecilIndustrial applications require materials with specific surface quality and hardness properties. Laser surface treatment stands out as a cost-effective and effective method that improves surface performance by changing the structural and physical properties of the material. 1.2379 cold work tool steel is a commonly used material in die and mold industries for injection mold inserts; therefore, the surface properties of the material play a significant role. In this study, it is aimed to optimize laser parameters; the laser power, pulse duration, repetition rate and line spacing for the responses such as hardness and surface roughness. For this purpose, 1.2379 cold work tool surfaces were treated using a commercially available industrial ytterbium low-power pulsed fiber laser experimentally. Experiments were conducted based on 34 full factorials. Vickers hardness and micro-roughness measurements were performed on the laser-treated surfaces. Regression models were developed using experimental data and the appropriate models were selected for each response. The response variables were then optimized based on stochastic optimization methods: Nelder-Mead, Differential Evolution, Random Search and Simulated Annealing. The results indicate that a maximum hardness of 495 HV0.5 and a minimum surface roughness of 0.277 mu m were achieved, corresponding to a 61% increase and a 43% decrease, respectively, compared to the base metal.