Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 3Citation - Scopus: 3Macroporous Polymer-Derived Ceramics Produced by Standard and Additive Manufacturing Methods: How the Shaping Technique Can Affect Their High Temperature Thermal Behavior(Elsevier B.V., 2024) Zambotti,A.; Kulkarni,A.; Semerci,T.; Vakifahmetoglu,C.; Pelanconi,M.; Bottacin,S.; Sorarù,G.D.This work proposes the processing of porous ceramic lattices via three polymer-derived ceramic routes, namely powder bed fusion and infiltration, fused filament fabrication and replica, and a direct replica of a foamed polymer. A common feature in the processing of these lattices is the use of the same polysilazane as the preceramic source for the Si-C-N-O network that builds up during ceramization. We adopted rotated cube, honeycomb and randomized cellular geometries as a matter of comparison for thermal exchange when an air flow is forced through the structures up to 1050 °C. The three procedural pathways are discussed in their limitations regarding geometry, polymer-to-ceramic conversion, high-temperature heat exchange performance and durability. In this regard, while rotated cube geometry results in the best thermal exchange and highest pressure drop, we show a correlation between chemical composition and high temperature oxidation of the Si-C-N-O network, possibly attributed to the selection of the processing routes. © 2024 The AuthorsArticle Citation - WoS: 27Citation - Scopus: 27In Vivo Bone Regeneration Capacity of Multiscale Porous Polycaprolactone-Based High Internal Phase Emulsion (polyhipe) Scaffolds in a Rat Calvarial Defect Model(American Chemical Society, 2023) Aldemir Dikici, Betül; Chen, Min-Chia; Dikici, Serkan; Chiu, Hsien-Chung; Claeyssens, FrederikGlobally, one of the most common tissue transplantationproceduresis bone grafting. Lately, we have reported the development of polymerizedhigh internal phase emulsions (PolyHIPEs) made of photocurable polycaprolactone(4PCLMA) and shown their potential to be used as bone tissue engineeringscaffolds in vitro. However, it is essential to evaluatethe in vivo performance of these scaffolds to investigatetheir potential in a clinically more relevant manner. Therefore, inthis study, we aimed to compare in vivo performancesof macroporous (fabricated using stereolithography), microporous (fabricatedusing emulsion templating), and multiscale porous (fabricated usingemulsion templating and perforation) scaffolds made of 4PCLMA. Also,3D-printed macroporous scaffolds (fabricated using fused depositionmodeling) made of thermoplastic polycaprolactone were used as a control.Scaffolds were implanted into a critical-sized calvarial defect, animalswere sacrificed 4 or 8 weeks after implantation, and the new boneformation was assessed by micro-computed tomography, dental radiography,and histology. Multiscale porous scaffolds that include both micro-and macropores resulted in higher bone regeneration in the defectarea compared to only macroporous or only microporous scaffolds. Whenone-grade porous scaffolds were compared, microporous scaffolds showedbetter performance than macroporous scaffolds in terms of mineralizedbone volume and tissue regeneration. Micro-CT results revealed thatwhile bone volume/tissue volume (Bv/Tv) values were 8 and 17% at weeks4 and 8 for macroporous scaffolds, they were significantly higherfor microporous scaffolds, with values of 26 and 33%, respectively.Taken together, the results reported in this study showed the potentialapplication of multiscale PolyHIPE scaffolds, in particular, as apromising material for bone regeneration.