Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 23Citation - Scopus: 31Nano-Caco3 Synthesis by Jet Flow(Elsevier Ltd., 2017) Ülkeryıldız, Eda; Kılıç, Sevgi; Özdemir, EkremA new methodology was introduced to produce hollow nano calcite particles in homogenous size distribution without aggregation. The design consisted of a jet flow system in which the crystallization region was separated from the stabilization region. The newly produced nano CaCO3 particles of about 140 nm were removed from the crystallization region as quickly as possible into the stabilization region before aggregation or crystal growth. In the stages of crystallization, the particles started to dissolve from their edges which opened-up the pores inside the particles. At the late stages of crystallization, the open pores closed. These particles were stable in Ca(OH)2 solution and no aggregation was detected. Different particles with different morphologies can be produced by adjusting the stages in the crystallization.Article Citation - WoS: 60Citation - Scopus: 66Preparation and Characterization of Calcium Stearate Powders and Films Prepared by Precipitation and Langmuir-Blodgett Techniques(American Chemical Society, 2010) Gönen, Mehmet; Öztürk, Serdar; Balköse, Devrim; Okur, Salih; Ülkü, SemraThe preparation of calcium stearate (CaSt2) using precipitation and Langmuir-Blodgett techniques was investigated in this study. While sodium stearate and calcium chloride were used in the precipitation process, calcium stearate nanofilms were produced from stearic acid and calcium chloride in sodium borate buffer with the Langmuir-Blodgett technique. Fourier transform infrared (FTIR) spectroscopy indicated carboxylate bands at 1577 and 1543 cm-1 in equal intensity in the powder form, but the films had a higher intensity 1577 cm-1 band than the 1543 cm-1 band. This showed the calcium ions associated with the COO- ions in the monodendate and bidendate structures in powders, and it was mainly in the bidendate structure in films. While characteristic peaks of CaSt2 at 2θ values of 6.40° and 19.58° were obtained in the X-ray diffraction (XRD) pattern of the dried powdered product, no sharp peaks were present in the 13 layer CaSt2 film. From scanning electron microscopy (SEM) micrographs, it was seen that calcium stearate powder had lamellar structure and the average particle size was 600 nm. The AFM picture of the CaSt2 film indicated the surface was not smooth with a peak to valley distance of 6 nm. © 2010 American Chemical Society.Article Citation - WoS: 49Citation - Scopus: 495-Fluorouracil Signaling Through a Calcium-Calmodulin Pathway Is Required for P53 Activation and Apoptosis in Colon Carcinoma Cells(Nature Publishing Group, 2013) Can, G.; Akpınar, B.; Baran, Yusuf; Zhivotovsky, B.; Olsson, M.5-Fluorouracil (5-FU) is an anti-metabolite that is in clinical use for treatment of several cancers. In cells, it is converted into three distinct fluoro-based nucleotide analogs, which interfere with DNA synthesis and repair, leading to genome impairment and, eventually, apoptotic cell death. Current knowledge states that in certain cell types, 5-FU-induced stress is signaling through a p53-dependent induction of tumor necrosis factor-receptor oligomerization required for death-inducing signaling complex formation and caspase-8 activation. Here we establish a role of calcium (Ca 2+) as a messenger for p53 activation in response to 5-FU. Using a combination of pharmacological and genetic approaches, we show that treatment of colon carcinoma cells stimulates entry of extracellular Ca 2+ through long lasting-type plasma membrane channels, which further directs posttranslational phosphorylation of at least three p53 serine residues (S15, S33 and S37) by means of calmodulin (CaM) activity. Obstructing this pathway by the Ca 2+ -chelator BAPTA (1,2-bis(o-aminophenoxy)ethane- N,N,N',N'-tetraacetic acid) or by inhibitors of CaM efficiently reduces 5-FU-induced caspase activities and subsequent cell death. Moreover, ectopic expression of p53 S15A in HCT116 p53 -/- cells confirmed the importance of a Ca 2+ -CaM-p53 axis in 5-FU-induced extrinsic apoptosis. The fact that a widely used therapeutic drug, such as 5-FU, is operating via this pathway could provide new therapeutic intervention points, or specify new combinatorial treatment regimes. © 2013 Macmillan Publishers Limited.Article Citation - WoS: 17Citation - Scopus: 19Nacl Tolerance in Lycopersicon Pennellii Introgression Lines: Qtl Related To Physiological Responses(Kluwer Academic Publishers, 2011) Frary, A.; Keleş, D.; Pinar, H.; Göl, D.; Doğanlar, S.The growth and ion content of salt sensitive Lycopersicon esculentum Mill. cv. M82 and salt tolerant L. pennellii Correll accession LA716 were examined under both control and stress conditions (150 mM NaCl). L. esculentum grew more vigorously than L. pennellii under optimal conditions, however, L. pennellii was able to maintain its growth better than cultivated tomato when the plants were exposed to salinity. Sodium content of both L. esculentum and L. pennellii increased as a result of NaCl stress. In addition, both species showed reduced potassium and calcium content due to salinity. The physiological traits were also measured in a population of 52 L. pennellii introgression lines grown under both normal and stress conditions. A total of 311 quantitative trait loci (QTL) were identified for the studied traits: plant height, stem diameter, leaf number, leaf and root fresh and dry mass, and sodium, potassium and calcium contents. Some of the loci (124) were identified under both control and stress conditions while 86 QTL were identified only under non-stress conditions and 101 loci were identified only under NaCl stress.