Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 2Citation - Scopus: 2Osteoblasts-Derived Exosomes as Potential Novel Communicators in Particle-Induced Periprosthetic Osteolysis(Elsevier, 2024) de Souza, Wanderson; Gemini-Piperni, S.; Ruivo, Carolina; Bastos, Nuno; Almeida, Sofia; Lopes, Daniel; Ribeiro, Ana R.The inflammatory response to wear particles derived from hip prothesis is considered a hallmark of periprosthetic osteolysis, which can ultimately lead to the need for revision surgery. Exosomes (Exos) have been associated with various bone pathologies, and there is increasing recognition in the literature that they actively transport molecules throughout the body. The role of wear particles in osteoblast-derived Exos is unknown, and the potential contribution of Exos to osteoimmune communication and periprosthetic osteolysis niche is still in its infancy. Given this, we investigate how titanium dioxide nanoparticles (TiO2 NPs), similar in size and composition to prosthetic wear particles, affect Exos biogenesis. Two osteoblastic cell models commonly used to study the response of osteoblasts to wear particles were selected as a proof of concept. The contribution of Exos to periprosthetic osteolysis was assessed by functional assays in which primary human macrophages were stimulated with bone-derived Exos. We demonstrated that TiO2 NPs enter multivesicular bodies, the nascent of Exos, altering osteoblast-derived Exos secretion and molecular cargo. No significant differences were observed in Exos morphology and size. However, functional assays reveal that Exos cargo enriched in uPA stimulates macrophages to a mixed M1 and M2 phenotype, inducing the release of pro- and anti-inflammatory signals characteristic of periprosthetic osteolysis. In addition, we demonstrated the expression of uPA in exosomes derived from the urine of patients with osteolysis. These results suggest that uPA can be a potential biomarker of osteolysis. In the future, uPa may serve as a possible non-invasive biomarker to identify patients at risk for peri-implant osteolysis.Review Citation - WoS: 13Citation - Scopus: 13Oxygen Delivery Biomaterials in Wound Healing Applications(WILEY-V C H VERLAG GMBH, 2023) Bayraktar, Sema; Üstün, Cansu; Kehr, Nermin SedaOxygen (O2) delivery biomaterials have attracted great interest in the treatment of chronic wounds due to their potential applications in local and continuous O2 generation and delivery, improving cell viability until vascularization occurs, promoting structural growth of new blood vessels, simulating collagen synthesis, killing bacteria and reducing hypoxia-induced tissue damage. Therefore, different types of O2 delivery biomaterials including thin polymer films, fibers, hydrogels, or nanocomposite hydrogels have been developed to provide controlled, sufficient and long-lasting O2 to prevent hypoxia and maintain cell viability until the engineered tissue is vascularized by the host system. These biomaterials are made by various approaches, such as encapsulating O2 releasing molecules into hydrogels, polymer microspheres and 3D printed hydrogel scaffolds and adsorbing O2 carrying reagents into polymer films of fibers. In this article, different O2 generating sources such as solid inorganic peroxides, liquid peroxides, and photosynthetic microalgae, and O2 carrying perfluorocarbons and hemoglobin are presented and the applications of O2 delivery biomaterials in promoting wound healing are discussed. Furthermore, challenges encountered and future perspectives are highlighted. Oxygen delivery (O2) biomaterials have attracted great interest in the treatment of chronic wounds due to their ability to continuously deliver oxygen and support cell viability. Therefore, various O2 generating sources such as solid inorganic peroxides, liquid peroxides and photosynthetic microalgae, and O2-carrying perfluorocarbons and hemoglobin are incorporated into different biomaterial networks for wound healing applications.imageReview Citation - Scopus: 121Natural and Synthetic Nanovectors for Cancer Therapy(Ivyspring International Publisher, 2023) Eftekhari, Aziz; Kryschi, Carola; Pamies, David; Ahmadian, Elham; Janas, Dawid; Davaran, Soodabeh; Khalilov, Rovshan; Güleç, ŞükrüNanomaterials have been extensively studied in cancer therapy as vectors that may improve drug delivery. Such vectors not only bring numerous advantages such as stability, biocompatibility, and cellular uptake but have also been shown to overcome some cancer-related resistances. Nanocarrier can deliver the drug more precisely to the specific organ while improving its pharmacokinetics, thereby avoiding secondary adverse effects on the not target tissue. Between these nanovectors, diverse material types can be discerned, such as liposomes, dendrimers, carbon nanostructures, nanoparticles, nanowires, etc., each of which offers different opportunities for cancer therapy. In this review, a broad spectrum of nanovectors is analyzed for application in multimodal cancer therapy and diagnostics in terms of mode of action and pharmacokinetics. Advantages and inconveniences of promising nanovectors, including gold nanostructures, SPIONs, semiconducting quantum dots, various nanostructures, phospholipid-based liposomes, dendrimers, polymeric micelles, extracellular and exome vesicles are summarized. The article is concluded with a future outlook on this promising field. © The author(s).Article Citation - WoS: 17Citation - Scopus: 16Development of Cissus Quadrangularis-Loaded Poss-Reinforced Chitosan-Based Bilayer Sponges for Wound Healing Applications: Drug Release and in Vitro Bioactivity(American Chemical Society, 2023) Değer Aker, Sibel; Tamburacı, Sedef; Tıhmınlıoğlu, FundaNowadays, antibiotic-loaded biomaterials have been widelyusedin wound healing applications. However, the use of natural extractshas come into prominence as an alternative to these antimicrobialagents in the recent period. Among natural sources, Cissus quadrangularis (CQ) herbal extract is usedfor treatment of bone and skin diseases in ayurvedic medicine dueto its antibacterial and anti-inflammatory effects. In this study,chitosan-based bilayer wound dressings were fabricated with electrospinningand freeze-drying techniques. CQ extract-loaded chitosan nanofiberswere coated on chitosan/POSS nanocomposite sponges using an electrospinningmethod. The bilayer sponge is designed to treat exudate wounds whilemimicking the layered structure of skin tissue. Bilayer wound dressingswere investigated with regard to the morphology and physical and mechanicalproperties. In addition, CQ release from bilayer wound dressings and in vitro bioactivity studies were performed to determinethe effect of POSS nanoparticles and CQ extract loading on NIH/3T3and HS2 cells. The morphology of nanofibers was investigated withSEM analysis. Physical characteristics of bilayer wound dressingswere determined with FT-IR analysis, swelling study, open porositydetermination, and mechanical test. The antimicrobial activity ofCQ extract released from bilayer sponges was investigated with a discdiffusion method. Bilayer wound dressings' in vitro bioactivity was examined using cytotoxicity determination, woundhealing assay, proliferation, and the secretion of biomarkers forskin tissue regeneration. The nanofiber layer diameter was obtainedin the range of 77.9-97.4 nm. The water vapor permeabilityof the bilayer dressing was obtained as 4021 to 4609 g/m(2)day, as it is in the ideal range for wound repair. The release ofthe CQ extract over 4 days reached 78-80% cumulative release.The release media were found to be antibacterial against Gram-negativeand Gram-positive bacteria. In vitro studies showedthat both CQ extract and POSS incorporation induced cell proliferationas well as wound healing activity and collagen deposition. As a result,CQ-loaded bilayer CHI-POSS nanocomposites were found as a potentialcandidate for wound healing applications.Article Citation - WoS: 45Citation - Scopus: 51Experimental Investigation of the Effect of Graphene/Water Nanofluid on the Heat Transfer of a Shell-And Heat Exchanger(Wiley-Hindawi, 2023) Zolfalizadeh, Mehrdad; Heris, Saeed Zeinali; Pourpasha, Hadi; Mohammadpourfard, Mousa; Meyer, Josua P. P.The most common type of heat exchanger used in a variety of industrial applications is the shell-and-tube heat exchanger (STHE). In this work, the impact of graphene nanoplate (GNP)/water nanofluids at 0.01 wt.%, 0.03 wt.%, and 0.06 wt.% on the thermal efficiency, thermal performance factor, pressure drop, overall heat transfer, convective heat transfer coefficient (CVHTC), and heat transfer characteristics of a shell-and-tube heat exchanger was examined. For these experiments, a new STHE was designed and built. The novelty of this study is the use of GNPs/water nanofluids in this new STHE for the first time and the fully experimental investigation of the attributes of nanofluids. GNP properties were analysed and confirmed using analyses including XRD and TEM. Zeta potential, DLS, and camera images were used to examine the stability of nanofluids at various periods. The zeta potential of the nanofluids was lower than -27.8 mV, confirming the good stability of GNP/water nanofluids. The results illustrated that the experimental data for distilled water had a reasonably good agreement with Sieder-Tate correlation. The maximum enhancement in the CVHTC of nanofluid with 0.06 wt.% of GNP, was equal to 910 (W/m(2)K), an increase of 22.47%. Also, the efficiency of the heat exchanger for nanofluid at 0.06 wt.% improved by 8.88% compared with that of the base fluid. The heat transfer rate of the nanofluid at maximum concentration and volume flow rate was 3915 (J/kg.K), an improvement of 15.65% over the base fluid. The pressure drops increased as the flow rate and concentration of the nanofluid increased. Although increasing the pressure drop in tubes would increase the CVHTC, it would also increase the power consumption of the pump. In conclusion, nanofluid at 0.06 wt.% had good performance.Article Citation - WoS: 9Citation - Scopus: 8Development of a New Electrochemical Sensor Based on Molecularly Imprinted Biopolymer for Determination of 4,4'-methylene Diphenyl Diamine(MDPI, 2023) Ghaani, Masoud; Büyüktaş, Duygu; Carullo, Daniele; Farris, StefanoA new molecularly imprinted electrochemical sensor was proposed to determine 4,4' methylene diphenyl diamine (MDA) using molecularly imprinted polymer-multiwalled carbon nanotubes modified glassy carbon electrode (MIP/MWCNTs/GCE). GCE was coated by MWCNTs (MWCNTs/GCE) because of their antifouling qualities and in order to improve the sensor sensitivity. To make the whole sensor, a polymeric film made up of chitosan nanoparticles was electrodeposited by the cyclic voltammetry method on the surface of MWCNTs/GCE in the presence of MDA as a template. Different parameters such as scan cycles, elution time, incubation time, molar ratio of template molecules to functional monomers, and pH were optimized to increase the performance of the MIP sensor. With a detection limit of 15 nM, a linear response to MDA was seen in the concentration range of 0.5-100 mu M. The imprinting factor (IF) of the proposed sensor was also calculated at around 3.66, demonstrating the extremely high recognition performance of a MIP/MWCNT-modified electrode. Moreover, the sensor exhibited good reproducibility and selectivity. Finally, the proposed sensor was efficiently used to determine MDA in real samples with satisfactory recoveries ranging from 94.10% to 106.76%.Book Part High-Performance Materials and Engineered Chemistry(CRC Press, 2018) Türk, Merve; Gümüş, Barış; Ustun, Fatma; Balköse, DevrimNano-sized nickel borate hydrate were precipitated from equimolar mixtures of dilute nickel nitrate and borax solutions at 25°C. Produced nickel borate samples were characterized by TGA, DSC, FTIR spectroscopy, X-ray diffraction, SEM, Elemental Analysis (EDX), Titration (nickel determination by EDTA, B<inf>2</inf>O<inf>3</inf> determination by NaOH), Particle Size Distribution, and Dehydration. The particles with 55 nm, 80 nm and 70 nm sizes were obtained for the cases without template, with span 60 and PEG 4000 in the reaction mixture respectively. The empirical formula of the vacuum dried precipitates were NiO.1.3B<inf>2</inf>O<inf>3</inf>.5.6 H<inf>2</inf>O, NiO.1.2B<inf>2</inf>O<inf>3</inf>.5.6 H<inf>2</inf>O and NiO.1.0B<inf>2</inf>O<inf>3</inf>.5.4 H<inf>2</inf>O for the cases without template, with span 60 and PEG 4000. The density of the nickel borate hydrates was around 2 g/ml and they had a color described by 157, 199 and 158 in RGB color scale. The nickel borate hydrates were amorphous in structure and no sharp peaks related to a crystal structure was present in their x-ray diffraction diagram. The effect of presence of span 60 and PEG 4000 were not significant on the particle size and chemical composition of the nanoparticles. © 2019 Elsevier B.V., All rights reserved.Article Citation - WoS: 6Citation - Scopus: 6First-Principles Study of Dissociation Processes for the Synthesis of Fe and Co Oxide Nanoparticles(American Chemical Society, 2018) Özdamar, Burak; Bouzid, Assil; Ori, Guido; Massobrio, Carlo; Boero, MauroThermal decomposition is a practical and reliable tool to synthesize nanoparticles with monodisperse size distribution and reproducible accuracy. The nature of the precursor molecules and their interaction with the environment during the synthesis process have a direct impact on the resulting nanoparticles. Our study focuses on widely used transition-metal (Co, Fe) stearates precursors and their thermal decomposition reaction pathway. We show how the nature of the metal and the presence or absence of water molecules, directly related to the humidity conditions during the synthesis process, affect the decomposition mechanism and the resulting transition-metal oxide building blocks. This, in turn, has a direct effect on the physical and chemical properties of the produced nanoparticles and deeply influences their composition and morphology.Article Citation - Scopus: 1Synthesis of Stable Nano Calcite(Turkish Chemical Society, 2018) Kılıç, SevgiSynthesis of calcium carbonate (CaCO3) particles in the presence of a population of carbon dioxide (CO2) bubbles was investigated in the calcium hydroxide (Ca(OH)2) solution, which is a natural stabilizer for CaCO3. Possible chemical speciation reactions were presented for an inorganic synthesis of hollow nano-CaCO3 particles. In the progress of CaCO3 synthesis, some of the particles started to dissolve at their edges and turned into hollow nano-CaCO3 particles. Some of the pores closed at the end of crystallization as a result of dissolution-recrystallization mechanism. Hollow nano-CaCO3 particles with sizes of about 300 nm were synthesized with a narrow size distribution. It was concluded that the hollow nano-CaCO3 particles could be advantageous due to lower weights and higher surface areas.Article Citation - WoS: 15Citation - Scopus: 13Environmentally Responsive Dual-Targeting Nanoparticles: Improving Drug Accumulation in Cancer Cells as a Way of Preventing Anticancer Drug Efflux(John Wiley and Sons Inc., 2018) Dağlıoğlu, CenkDrug targeting and stimuli-responsive drug release are 2 active areas of cancer research and hold tremendous potential in the management of cancer drug resistance. In this study, I addressed this issue and focused on the synthesis and characterization of pH-responsive Fe3O4@SiO2(FITC)-BTN/folic acid/DOX multifunctional nanoparticles aiming to increase drug accumulation in malignancies with both dual active targeting and endosomal drug release properties. Dye-doped silica magnetic-fluorescent composite was constructed by a simple coprecipitation of Fe+2/Fe+3 salts followed by sol-gel formation and dual-targeting function was obtained by conjugating folate and biotin moieties on the silica surface of nanoparticles via an esterification reaction. Doxorubicin was then successfully attached on the amine-functionalized nanoparticles using a pH-sensitive Schiff-base formation. The physicochemical characterization of the structure was performed by dynamic light scattering, zeta potential measurement, X-ray diffraction, Fourier transform infrared spectroscopy, electron microscopy techniques, and an in vitro pH-dependent release study. Cellular uptake and cytotoxicity experiments demonstrated an enhanced intracellular delivery and reduction of cancer cell viability in the cervical carcinoma HeLa cell line. Furthermore, proapoptotic studies showed that the nanoparticles increased the apoptotic rates within the same cancer cells. The preliminary cell tests confirm the potential of these multifunctional nanoparticles against the development of drug resistance in cancer cells.
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