Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
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Article Plasma Proteomic Markers of Interleukin-1β Pathway Associated With Incident Age-Related Macular Degeneration in Persons With Aids(Elsevier, 2025) Hunt, Peter W.; Olshen, Adam B.; Murad, Natalia; Ambayec, Gabrielle C.; Sezgin, Efe; Schneider, Michael F.; Jabs, Douglas A.Objective To evaluate the associations of plasma inflammatory proteins with age-related macular degeneration (AMD) in persons with the AIDS, using a discovery-based proteomics approach. Design A nested case-control study (analysis 1) and nested cohort study (analysis 2). Participants Persons with AIDS enrolled in the Longitudinal Study of the Ocular Complications with AIDS (LSOCA). Methods Cryopreserved plasma specimens obtained at baseline were assayed for inflammatory proteins using the Olink Inflammation Explore Panel 1. In analysis 1, baseline proteomic profiles for 26 persons with AIDS and incident intermediate-stage AMD 5 to 10 years after baseline and 49 matched controls (matched for age, biologic sex, race/ethnicity, and follow-up) without AMD were compared. In analysis 2, 475 persons from LSOCA with baseline plasma inflammatory proteomic profile measurements were followed for incident cataract and mortality. Main Outcome Measures Incident intermediate-stage AMD; incident cataract; and mortality. Results Of 365 measurable plasma inflammatory proteins, 118 (32%) were associated with incident intermediate-stage AMD at the false discovery rate-adjusted Q < 0.05 level after adjustment for smoking, CD4+ T count, and plasma human immunodeficiency virus RNA level. Gene ontology pathway enrichment analysis identified the interleukin (IL)-1 beta pathway and wound healing pathways, including tissue inhibitor of metalloproteinase 3, as significantly associated with incident AMD. These associations were qualitatively different from those associated with incident cataracts, where elevated levels of inflammatory proteins were associated with a decreased risk of cataracts. A much broader number of inflammatory pathways, including those related to the adaptive immune system, were associated with mortality. Conclusions Upregulation of the IL-1 beta pathway appears to be associated with an increased risk of incident AMD in persons with AIDS. Given the availability of inhibitors of this pathway, inhibition of the IL-1 beta pathway may provide a therapeutic avenue for treatment of AMD. Financial Disclosure(s) Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article. Ophthalmology Science 2025;5:100794 (c) 2025 by the American Academy of Ophthalmology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Article Citation - WoS: 8Citation - Scopus: 8A Review of the Experimental and Numerical Studies on the Compression Behavior of the Additively Produced Metallic Lattice Structures at High and Low Strain Rates(KeAi Communications Co., 2025) Bin Riaz, Muhammad Arslan; Guden, MustafaRecent advances in additive manufacturing have enabled the construction of metallic lattice structures with tailored mechanical and functional properties. One potential application of metallic lattice structures is in the impact load mitigation where an external kinetic energy is absorbed by the deformation/ crushing of lattice cells. This has motivated a growing number of experimental and numerical studies, recently, on the crushing behavior of additively produced lattice structures. The present study overviews the dynamic and quasi-static crushing behavior of additively produced Ti64, 316L, and AlSiMg alloy lattice structures. The first part of the study summarizes the main features of two most commonly used additive processing techniques for lattice structures, namely selective-laser-melt (SLM) and electrobeam-melt (EBM), along with a description of commonly observed process induced defects. In the second part, the deformation and strain rate sensitivities of the selected alloy lattices are outlined together with the most widely used dynamic test methods, followed by a part on the observed microstructures of the SLM and EBM-processed Ti64, 316L and AlSiMg alloys. Finally, the experimental and numerical studies on the quasi-static and dynamic compression behavior of the additively processed Ti6 4, 316L, and AlSiMg alloy lattices are reviewed. The results of the experimental and numerical studies of the dynamic properties of various types of lattices, including graded, non-uniform strut size, hollow, non-uniform cell size, and bio-inspired, were tabulated together with the used dynamic testing methods. The dynamic tests have been noted to be mostly conducted in compression Split Hopkinson Pressure Bar (SHPB) or Taylor-and direct-impact tests using the SHPB set-up, in all of which relatively small-size test specimens were tested. The test specimen size effect on the compression behavior of the lattices was further emphasized. It has also been shown that the lattices of Ti6 4 and AlSiMg alloys are relatively brittle as compared with the lattices of 316L alloy. Finally, the challenges associated with modelling lattice structures were explained and the micro tension tests and multi-scale modeling techniques combining microstructural characteristics with macroscopic lattice dynamics were recommended to improve the accuracy of the numerical simulations of the dynamic compression deformations of metallic lattice structures. (c) 2025 China Ordnance Society. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).Article Citation - WoS: 1Legume and Nut Flours From the Mediterranean Area: Proximate Compositions, Techno-Functionalities, and Spectroscopy Patterns as a Function of Species, Origin, and Treatment(Elsevier, 2025) Cappa, Carola; Ozen, Banu; Tokatli, Figen; Imeneo, Valeria; Aguilo-Aguayo, Ingrid; Sahan, Yasemin; Alamprese, CristinaThis study systematically evaluates proximate composition, color, techno-functionalities, and spectroscopy patterns of 19 legume and 16 nut commercial flours of the Mediterranean area. Effect of species, origin, and treatment were analyzed using a Generalized Linear Model. Except for legume proteins, species and origin significantly (p <= 0.001) affected flour composition, while heat treatment only had a significant effect (p <= 0.05) on nuts. A large variability was observed in fats (0.6-69 g/100g) and proteins (3.7-36 g/100g), and the FT-IR spectra reflected the 35-flours composition. Principal component model clearly distinguished flours based on their carbohydrate, fat, and protein contents. For legumes, color indices, bulk density, and emulsifying properties were significantly affected by species, origin, and treatment, while foaming properties were influenced only by species. For nuts, oil absorption capacity, emulsion properties, and foaming properties were significantly affected by species, origin, and treatment. The origin had a significant effect on water retention capacity (40-433 %) of nuts. The study findings contribute to a better knowledge of Mediterranean legume and nut flours, clarifying their distinct properties for a higher awareness in their use for the design of food products with tailored features.Article Citation - WoS: 2Citation - Scopus: 1Cross-Linked Carboxymethyl Cellulose Biosorbent for Zinc Removal: a Sustainable Remediation of Heavy Metal-Polluted Waters(Springer Heidelberg, 2025) Celgan, Dilber; Karadag, Asiye; Karim, Barna Jalaluddin Mohammad; Recepoglu, Yasar Kemal; Arar, OzgurThis study focuses on the preparation and characterization of cross-linked carboxymethyl cellulose (CMC) biosorbent for efficient removal of Zn2(+) ions from aqueous solutions. The microstructural features of the biosorbent were examined using scanning electron microscopy (SEM), while elemental analysis was conducted using an elemental analyzer to determine carbon (C), hydrogen (H), nitrogen (N), and sulfur (S) content. Fourier transform infrared (FTIR) spectroscopy was employed to identify functional groups within the biosorbent. Sorption experiments revealed that increasing the biosorbent dose led to higher Zn2(+) removal rates until equilibrium was reached. The optimal pH for Zn2(+) removal was determined to be >= 5, attributed to the conversion of acetate group to its ionic form. Rapid kinetics were observed, with 99% removal achieved within 5 min. The biosorbent exhibited a maximum sorption capacity of 10.809 mg/g and a removal rate of 99% at pH 5. Desorption studies demonstrated efficient Zn2(+) recovery using 0.25 M HCl solution, with a total desorption rate exceeding 99%. The findings indicate the potential for cost-effective regeneration of the biosorbent using dilute acid solutions, enhancing its sustainability and practical applicability in water purification processes. Additionally, the biosorbent's selectivity for Zn2(+) ions over competing ions and its effectiveness in treating real water samples, including those containing Na+, K+, Ca2(+), and Mg2(+), highlight its suitability for practical water purification applications.Article Citation - WoS: 2Citation - Scopus: 2Impact of Green Wall and Roof Applications on Energy Consumption and Thermal Comfort for Climate Resilient Buildings(Mdpi, 2025) Turhan, Cihan; Carpino, Cristina; Austin, Miguel Chen; Ozbey, Mehmet Furkan; Akkurt, Gulden GokcenNowadays, reducing energy consumption and obtaining thermal comfort are significant for making educational buildings more climate resilient, more sustainable, and more comfortable. To achieve these goals, a sustainable passive method is that of applying green walls and roofs that provide extra thermal insulation, evaporative cooling, a shadowing effect, and the blockage of wind on buildings. Therefore, the objective of this study is to evaluate the impact of green wall and roof applications on energy consumption and thermal comfort in an educational building. For this purpose, a university building in the Csb climate zone is selected and monitored during one year, as a case study. Then, the case building is modelled in a well-calibrated dynamic building energy simulation tool and twenty-one different plant species, which are mostly used for green walls and roofs, are applied to the envelope of the building in order to determine a reduction in energy consumption and an increase in thermal comfort. The Hedera canariensis gomera (an ivy species) plant is used for green walls due to its aesthetic appeal, versatility, and functional benefits while twenty-one different plants including Ophiopogon japonicus (Mando-Grass), Phyllanthus bourgeoisii (Waterfall Plant), and Phoenix roebelenii (Phoenix Palm) are simulated for the green roof applications. The results show that deploying Hedera canariensis gomera to the walls and Phyllanthus bourgeoisii to the roof could simultaneously reduce the energy consumption by 9.31% and increase thermal comfort by 23.55% in the case building. The authors acknowledge that this study is solely based on simulations due to the high cost of all scenarios, and there are inherent differences between simulated and real-world conditions. Therefore, the future work will be analysing scenarios in real life. Considering the limited studies on the effect of different plant species on energy performance and comfort, this study also contributes to sustainable building design strategies.Article Citation - WoS: 5Citation - Scopus: 7Polycentricity and Regional Economic Resilience: a Ridge Regression Approach(Elsevier Sci Ltd, 2025) Cifci, Burcu Degerli; Duran, Hasan EnginResilience and "polycentricity" have surged as popular concepts over the recent decades, although the link between the two has not yet been investigated empirically. Identification of this relationship and its theoretical justification are politically crucial to shed light on prospective policies for urbanization and regionalization. Thus, the aim of this study is to investigate the impact of polycentricity/monocentricity on the regional resilience of Turkish (Nuts-2) regions against the global financial crisis in 2008/09. This paper also identifies the channels through which it can influence resilience. Through the application of a rich set of empirical tools, including computation of monocentricity degree, resistance, recovery, and adaptability indexes based on national and regional business cycle turning points, LOESS, RIDGE regressions, and inferential mediation tests, three main conclusions were obtained. First, polycentric regions were evidently more resistant to the crisis compared to monocentric morphologies; the later were more industrialized and open to trade, which made them more vulnerable to the crisis. Second, polycentric spatial structures were found to recover more quickly compared to monocentric regions. Third, monocentric regions clearly adapt better to long-term trajectories. In sum, the wellknown strategy of the European Union rooted in "polycentric development" can still be valid for the purposes such as resisting to and recovering from economic disruptions. However, in the long-run, polycentrilization can hardly be seen as an optimal strategy, particularly in the context of adapting to the future trajectories.Article Citation - WoS: 3Citation - Scopus: 2Cradle-To Life Cycle Assessment of Heavy Machinery Manufacturing: a Case Study in Türkiye(Springer, 2025) Üçtuğ, F.G.; Ediger, V.Ş.; Küçüker, M.A.; Berk, İ.; İnan, A.; Moghadasi Fereidani, B.Purpose: Amidst accelerated industrialization and urbanization, the surge in heavy equipment production, crucial for construction, mining, industry, and transportation, necessitates a comprehensive examination of its environmental implications from a sustainability standpoint. This study aims to scrutinize the environmental impacts of manufacturing forklifts and semi-trailers in Türkiye, employing the life cycle assessment (LCA) methodology. Methods: The life cycle assessment (LCA) methodology is the foundational framework for evaluating the environmental impacts associated with forklift and semi-trailer manufacturing. A cradle-to-gate approach was employed. CCaLC2 software alongside the Ecoinvent 3.0 database and CML LCIA methodology was used. Results: The carbon footprint analysis reveals that the production of a single forklift and semi-trailer generates 10.8 tons CO2eq. and 24.9 tons CO2eq. of emissions, respectively. Considering the mass of the machinery, these figures translate to 2.8 ton CO2eq./ton machinery and 1.57 ton CO2eq/ton machinery for the forklift and semi-trailer, respectively. These results were found to be consistent with values reported for similar (but not identical) heavy machinery. Notably, the predominant share of environmental impact stems from raw material acquisition for both products, with subsequent contributions from various production stages. Steel utilization emerges as the primary contributor to all environmental impact categories, constituting an average contribution of 75%. Noteworthy exceptions include the acidification potential of forklift production, where the incorporation of the engine emerges as the primary hotspot with a significant 38% contribution. Conclusions: The findings present the environmental footprint associated with forklift and semi-trailer manufacturing, emphasizing the pivotal role of raw material acquisition, particularly steel utilization. Insights derived from this environmental impact assessment provide invaluable guidance for enhancing environmental sustainability. Decision-makers and industry stakeholders can leverage these conclusions to implement targeted measures, such as exploring alternative materials or refining production processes, to mitigate the environmental consequences of resource-intensive heavy equipment manufacturing, aligning with broader sustainability objectives. © The Author(s) 2025.Article Citation - WoS: 3Citation - Scopus: 3Hybrid Silica Aerogels From Bridged Silicon Alkoxides: Ultralow Thermal Conductivity for Low-Temperature Applications(Springer, 2025) Abebe, A. M.; Biesuz, M.; Vakifahmetoglu, C.; Cassetta, M.; Soraru, G. D.Hybrid silica aerogels are promising materials for thermal insulation applications. Highly porous aerogels were synthesized from bridged bis(triethoxysilyl)methane BTEM and triethoxysilane TREOS silicon alkoxides via the sol-gel process. The carbon content in the hybrid aerogels decreased with increasing amounts of TREOS. Crack-free monolith aerogels were synthesized through supercritical drying, which is crucial for thermal and optical investigations. The aerogels are characterized by high BET surface areas ranging from 700 to 1400 m(2)/g, pore volumes between 2.0 and 10.5 cm(3)/g, and a maximum porosity of 95%. The thermal conductivity of the aerogels at room temperature was measured via a hot disk apparatus. The materials exhibited ultralow thermal conductivity, reaching a minimum value of 15 mW/mK. This value ranks among the lowest reported values for silica-based aerogels in the literature. Optical transmittance measurements indicated high transparency, exceeding 80% in the visible region. Therefore, these exceptional properties of low density, high optical transparency, and low thermal conductivity make these materials promising candidates for transparent insulation applications.Article Citation - WoS: 3Citation - Scopus: 4Magsity Platform: a Hybrid Magnetic Levitation-Based Lensless Holographic Microscope Platform for Liquid Density and Viscosity Measurements(Royal Soc Chemistry, 2025) Ince, Oyku Doyran; Tekin, H. CumhurThe viscosity and density of liquids are the most extensively studied material properties, as their accurate measurement is critical in various industries. Although developments in micro-viscometers have overcome the limitations of traditional bulky methods, more accessible technologies are required. Here, we introduce a novel magnetic levitation-based method to measure the viscosity and density of solutions in a microcapillary channel. This principle exploits microparticles as microsensors to correlate levitation time and height with solutions' viscosity and density, using buoyancy and drag forces. The platform has an integrated lensless holographic microscope, providing a hybrid system for in situ and precise measurements. By utilizing this hybrid technology, portable, rapid and cost-effective measurements can be conducted. This platform enables viscosity and density measurements within 7 minutes, achieving high accuracies of at least 97.7% and 99.9%, respectively, across an operation range of 0.84-5.09 cP and 1.00-1.09 g cm-3. The platform is utilized to clearly distinguish differences in the spent cell culture medium across various cell lines. This method, as presented, can be readily applied to measure a diverse array of liquids in multiple domains, encompassing biotechnology, medicine, and engineering.Article Citation - WoS: 5Citation - Scopus: 5Nanoarchitectonics Approach To Graphite/Starch-supported Bioelectrode for Enhanced Supercapacitor Performance(Elsevier, 2025) Goren, Aysegul Yagmur; Dincer, IbrahimThere has been an increasing interest in finding suitable materials for supercapacitor applications in response to the growing need for energy, to use alternative energy sources to fossil fuels in addition to energy storage. In this regard, bio-based carbon-loaded materials can be a promising option for high-performance supercapacitors because of their abundance, diversity, and reproducibility with waste management strategies. In this study, a new graphite-loaded bioelectrode is synthesized for supercapacitor application. The electrochemical performance of the synthesized electrode is tested at room temperature using the cyclic voltammetry method, and the capacity and energy density of the electrodes are evaluated. The electrochemical performance of 1 g of graphiteloaded bioelectrode was 3.5 mA/cm2, while the specific capacitance value was 355.6 F/g at a current density of 0.5 A/g. Furthermore, the bioelectrode provided significant cyclic stability with 93.5% in specific capacitance value after 5000 charge/discharge cycles at the current density of 0.5 A/g. Consequently, the synthesized bioelectrode can be a promising option for energy storage as a sustainable electrode due to its superior conductivity, stability, and low cost.