Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Nanoencapsulation of Hydroxytyrosol Extract of Fermented Olive Leaf Brine Using Proniosomes(Wiley, 2025) Kadiroglu, Pinar; Kilincli, Betul; Ilgaz, Ceren; Bayindir, Zerrin Sezgin; Kelebek, Hasim; Helvacioglu, Selin; Ozhan, GunesBACKGROUND: Olive leaves are rich in bioactive compounds with potential health benefits; however, their limited bioavailability and stability hinder their effective utilization. Emerging technologies, nanocarrier-based delivery systems, have shown promise in enhancing these properties. RESULTS: The optimal conditions for proniosome formulation were 50 rpm rotational speed and 35 degrees C, achieving 81.20 +/- 0.80% encapsulation efficiency. Particle sizes ranged from 188.6 to 248.9 nm, with a zeta potential of similar to-30 mV, indicating high stability and resistance to aggregation. Advanced instrumental analysis confirmed interactions between the extract and proniosome components. After 30 days at 4 degrees C, extract-loaded proniosomes maintained better homogeneity and lower polydispersity index. Cytotoxicity studies showed that both the extract and its proniosomal form were nontoxic to HEK293T cells up to 200 mu g mL(-1). In zebrafish assays, minimal larval mortality was observed up to 3200 mu g mL(-1) for the extract, while no mortality occurred up to 1600 mu g mL(-1) for the proniosomal extract, highlighting its improved safety profile. CONCLUSION: The findings from this research could contribute to the advancement of sustainable and health-promoting food innovations by integrating cutting-edge nanotechnology-driven encapsulation strategies into plant-based food formulations. (c) 2025 Society of Chemical Industry.Conference Object Citation - WoS: 1Citation - Scopus: 1Microstructural Evolution During Homogenization Heat Treatment of Aa 6063 Alloy in Batch and Continuous Furnaces(Springer international Publishing Ag, 2024) Obali, Akin; Gokelma, Mertol; Urk, Deniz Kavrar; Dogan, Murat; Gokce, GokcenHomogenization heat treatment after casting is performed to eliminate the dendritic segregation and coarse eutectic intermetallic phases since they reduce the fracture toughness of aluminium alloys. By the homogenization treatment, ss-AlFeSi can be converted to more spherical alpha-AlFeSi particles. The ss -> a transition is crucial because the ss-AlFeSi particles cause a number of surface defects and limit the extrudability. Also, the rate of cooling in the homogenization furnace is one of the critical influencing factors on the size of the Mg2Si precipitates which affect the mechanical properties positively. In this study, billets of AA 6063 from the same cast were put through homogenization heat treatment by using batch-type and continuous furnaces. The solution, quenching, and aging heat treatment were applied to each sample. Microstructural characterization by SEM and the hardness test were conducted to understand the effects of the furnace type on the mechanical properties of aged AA 6063 aluminium.