Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 2Citation - Scopus: 2Determination of Retrorsine in Thyme Via Molecularly Imprinted Electrochemical Sensor: Validation and Comparison With Chromatographic Technique(Elsevier Sci Ltd, 2025) Tunc-Ata, Melek; Akturk, Ezgi Zekiye; Njjar, Muath; Kaya, Ahmet; Akdogan, Abdullah; Onac, CananPyrrolizidine alkaloid (PA) toxicity is a growing public health concern, especially with rising herbal product use during the pandemic, highlighting the need for accurate exposure data. Retrorsine (RTS), a retronecine-based PA, is highly toxic, causing liver damage, mutagenicity, and DNA cross-linking through metabolic activation. In the light of the need for a practical alternative to monitor pyrrolizidine alkaloid contamination in herbal products, a molecularly-imprinted-polymer sensor (MIPs-GCE) was used for exploring the electrochemical behavior of RTS electrochemical behavior using cyclic voltammetry and the selective detection of RTS using square wave voltammetry. The sensor demonstrated a linear-detection range of 0.05-2 nM, with a LOD of 0.02869 nM. The sensor's accuracy was validated by analyzing thyme samples, detecting RTS concentrations of 0.5168 and0.5345 nM with RSD of 2.4 % and 1.9 %. These results closely aligned LC-MS/MS values of 0.5142 and 0.5267 nM, confirming the sensor's precision. The sensor demonstrated high selectivity, low detection limits, and practical applicability, ensuring reliable and efficient RTS detection in the presence of twenty-eight different PA compounds. This study introduces a novel, reliable, and straightforward method for detecting PAs, with a specific focus on RTS, offering an enhancement to existing analytical techniques and presenting a complementary alternative in chromatographic applications such as LC-MS/MS, HPLC and GC-MS.Article Citation - WoS: 2Citation - Scopus: 3Unlocking the Biological Potential of Emulsion-Templated Matrices Through Surface Engineering for Biomedical Applications(Elsevier Sci Ltd, 2025) Sert, Emircan; Ozmen, Ece; Owen, Robert; Dikici, Betul AldemirEmulsion templating is a highly advantageous route for the fabrication of porous materials, enabling the development of matrices with high porosity, high interconnectivity, and precise morphological control. Synthetic polymers are most widely used in the fabrication of emulsion-templated tissue engineering scaffolds due to their superior mechanical strength, ease of fabrication, control over polymer properties, and batch-to-batch stability. The biological response is strongly associated with the surface properties of the biomaterials; however, scaffolds constructed from synthetic polymers often lack cell recognition sites and exhibit limited bioactivity. Thus, synthetic polymer-based porous matrices commonly require surface post-modification to improve cell adhesion, proliferation, migration, gene expression, and differentiation processes. To date, extensive work has been carried out investigating surface modification of scaffolds fabricated via traditional scaffold fabrication techniques. Still, studies addressing the post-modification of emulsion-templated matrices are comparatively limited despite an exponential increase in the number of publications on emulsion templating for tissue engineering in recent years. This review will first examine the fundamentals of emulsion templating, then describe cell adhesion and the characteristics of scaffolds that influence cell-material interactions. It will then provide a comprehensive analysis of surface modification techniques and recent advancements in surface-modified emulsion-templated matrices for tissue engineering applications. Finally, we address the challenges and future directions in this rapidly evolving field. We anticipate that this comprehensive literature review will present the current state-of-the-art and serve as a valuable roadmap for researchers seeking to enhance the biological performance of their emulsion-templated scaffolds through surface modifications. Such scaffold optimisation strategies not only improve cell-material interactions but also hold translational potential for advancing human healthcare through more effective regenerative therapies.Article Citation - WoS: 1Citation - Scopus: 2Scalable Growth of Optically Uniform Mows2 Alloys by Sulfurization of Ultrathin Mo/W Stacks(Elsevier Sci Ltd, 2025) Panasci, Salvatore Ethan; Schiliro, Emanuela; Koos, Antal; Kutlu, Tayfun; Sahin, Hasan; Roccaforte, Fabrizio; Giannazzo, FilippoTwo-dimensional (2D) transition metal dichalcogenides (TMDs) ternary alloys, such as MoxW1-xS2, are very appealing for the possibility of continuously tuning their excitonic bandgap by the composition. However, the deposition of ultra-thin (monolayers or few-layers) alloys with laterally uniform composition on large area represents a main challenge of currently adopted synthesis methods. In this work, we demonstrated the growth of highly uniform Mo0.5W0.5S2 bi-layers on cm2 size SiO2/Si substrates by employing a simple and scalable approach, i.e. the sulfurization of a pre-deposited ultra-thin Mo/W stack at a temperature of 700 degrees C. Comparison of Mo(1.2 nm)/SiO2, W(1.2 nm)/SiO2, and Mo(1.2 nm)/W(1.2 nm)/SiO2 samples after identical sulfurization conditions revealed very different results, i.e. (i) a uniform monolayer (1L) MoS2 film, (ii) separated multilayer WS2 islands, and (iii) a uniform bilayer (2L) Mo0.5W0.5S2 film. This indicates how W surface diffusion and coalescence on SiO2 surface plays a main role in WS2 islands formation, whereas the reaction between S vapour with Mo films or Mo/W stacks represents the dominant mechanism for the formation of MoS2 and the MoWS2 alloy. Micro-photoluminescence (PL) mapping of the obtained 2L-Mo0.5W0.5S2 film showed an excellent uniformity of light emission on large area with an exciton peak at 1.97 eV, significantly blue-shifted with respect to PL emission of 1L-MoS2 at 1.86 eV. Such highly uniform optical properties make the grown MoWS2 alloy very promising for optoelectronic applications.Article Citation - WoS: 5Citation - Scopus: 7Polycentricity and Regional Economic Resilience: a Ridge Regression Approach(Elsevier Sci Ltd, 2025) Cifci, Burcu Degerli; Duran, Hasan EnginResilience and "polycentricity" have surged as popular concepts over the recent decades, although the link between the two has not yet been investigated empirically. Identification of this relationship and its theoretical justification are politically crucial to shed light on prospective policies for urbanization and regionalization. Thus, the aim of this study is to investigate the impact of polycentricity/monocentricity on the regional resilience of Turkish (Nuts-2) regions against the global financial crisis in 2008/09. This paper also identifies the channels through which it can influence resilience. Through the application of a rich set of empirical tools, including computation of monocentricity degree, resistance, recovery, and adaptability indexes based on national and regional business cycle turning points, LOESS, RIDGE regressions, and inferential mediation tests, three main conclusions were obtained. First, polycentric regions were evidently more resistant to the crisis compared to monocentric morphologies; the later were more industrialized and open to trade, which made them more vulnerable to the crisis. Second, polycentric spatial structures were found to recover more quickly compared to monocentric regions. Third, monocentric regions clearly adapt better to long-term trajectories. In sum, the wellknown strategy of the European Union rooted in "polycentric development" can still be valid for the purposes such as resisting to and recovering from economic disruptions. However, in the long-run, polycentrilization can hardly be seen as an optimal strategy, particularly in the context of adapting to the future trajectories.Article Citation - WoS: 2Citation - Scopus: 2Surface Sediments as a Sink and Risk Source for Legacy Pops During Waste Management Practices(Elsevier Sci Ltd, 2025) Demirtepe, HalePersistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) are globally recognized contaminants due to their persistence, bioaccumulative properties, and toxicity. Despite regulatory efforts, these compounds continue to enter the environment through improper waste management practices, including shipbreaking activities. This study investigates the PCB and PBDE contamination of marine sediments along a 30 km coastline in Aliaga, T & uuml;rkiye, involving one of the world's largest shipbreaking yards. Sixteen surface sediment samples were analyzed for 46 PCB and 23 PBDE congeners. The results revealed Sigma 46PCBs ranging from 5.17 to 4750 ng/g and Sigma 23PBDEs from non-detectable to 5053 ng/g. Shipbreaking activities exhibited the highest concentrations, while the sediments sampled close to beaches had the lowest POP contamination. Source apportionment using principal component analysis (PCA) identified distinct contamination patterns, associating higher-chlorinated PCBs with shipbreaking and lower-chlorinated PCBs and PBDEs with land-based industrial emissions and urban runoff. Ecological risk evaluation showed that most sediment samples exceeded sediment quality guidelines, with some PCB and PBDE congeners posing moderate to high risks to benthic ecosystems. Particularly, PCBs 28 and 52 exhibited low to high risk for almost all sediment samples. This study emphasizes the urgent need for improved waste management practices, particularly for POP-containing materials, to mitigate ecological risks. Shipbreaking yards are identified as hotspots for legacy POP contamination, necessitating international collaboration and stricter enforcement of environmental regulations as shipbreaking operations encompass cross-country transfer of wastes. Findings highlight the critical importance of remediation strategies to protect marine environments.Article Citation - WoS: 1Citation - Scopus: 1Investigating the Behavior of D-Glucose, D-Fructose, and D-Allulose in Aqueous Media by Molecular Dynamics Simulations(Elsevier Sci Ltd, 2025) Bugday, Zinnur Yagmur; Bayramoglu, Beste; Oztop, Halil MecitIsomeric monosaccharides may have different hydration behaviors, leading to distinct physicochemical properties in solutions. In this work, the aqueous behavior, structure, and hydration properties of D-allulose, Dglucose, and D-fructose were investigated as a function of concentration by molecular dynamics simulations. This is the first computational study investigating D-allulose compared to its two isomers. The dynamics were analyzed through self-diffusion coefficients; hydration was characterized by hydrogen bond (HB) analyses. Radial distribution functions were used to probe water structuring around sugar oxygens. Results show the hydration number and the fraction of bound water in solution were the highest for glucose, followed by fructose and allulose. The C3 epimerization of fructose into allulose highly promotes the allulose pyranoses to form intramolecular HBs, significantly limiting their water-holding capacity. This may possibly explain the favorability of furanose forms over pyranose forms in aqueous allulose solutions, opposing glucose and fructose in solution.Article Citation - WoS: 5Citation - Scopus: 5Investigating the Impact of Sprouting on Starch Properties of Wheat Flour and Non-Linear Rheological Behavior of Bread Dough(Elsevier Sci Ltd, 2025) Berk, Berkay; Glaue, Selale Oncu; Bayram, Ozge Yildiz; Unluturk, SevcanThis study investigated the physical and technological properties of the sprouted refined (SR), sprouted whole (SW) and unsprouted refined (UR) wheat flours to explore their potential in bread production. The effects of sprouting on the starch properties, including molecular weight, amylase activity, pasting, and crystallinity, were examined. Rheological properties were measured using farinograph, extensograph, and mixograph instruments. Then, a mixture design was used to optimize the flour blends for bread dough formulation. The non-linear rheological properties of the dough samples prepared by these flour blends were analyzed using large amplitude oscillatory shear (LAOS) test. Molecular weight (UR: 669.6 kDa and SR: 390.4 kDa) and the falling number (UR: 485.5 s, SR: 132 s and SW: 62 s) decreased with sprouting. The water absorption of UR and SR were similar (55 and 54 %), but SW had higher water absorption being 61%. The mixograph peak torque (UR: 78.3 %Tq, SR: 63.6 %Tq and SW: 57.4 %Tq) values decreased with sprouting. Comparison of the optimum blends with commercial counterparts in bread dough production was conducted by principal component analysis (PCA) using different rheological properties (GL, eta L,S, and T) at different strain values. The results showed that using a blend of 50.5% UR, 48.5% SR, and 1% SW, as well as 5.1% UR, 51.3% SR, and 43.6% SW, in bread dough formulation resulted in non-rheological properties similar to those of their commercial counterparts: refined bread flour and whole wheat bread flour.Article Citation - WoS: 2Citation - Scopus: 2Temporal Electroencephalography Features Unveiled Via Olfactory Stimulus as Biomarkers for Mild Alzheimer's Disease(Elsevier Sci Ltd, 2025) Olcay, Bilal Orkan; Pehlivan, Murat; Karacali, BilgeAim: Our primary aim is to capture and use the timings of the characteristic brain responses to olfactory stimulation for mild Alzheimer's disease diagnosis purposes. Proposed method: Our method identifies the timings of short-lived signal segments where characteristic distances between pre- and post-stimulus relative spectral energies are attained for each EEG channel and frequency band. These timings and timing-derived features were subsequently used in a leave-one-subject-out cross-validation scenario to assess the diagnostic performance of our framework. We evaluated seven distinct statistical distance measures to determine the most effective one for characterizing the neurological conditions of the subjects. Results: The average cross-validation performance shows that our framework achieved 87.50% diagnosis performance. The frequently used features were mainly derived from the delta and alpha activity of the prefrontal region (Fp1) and the beta activity of the parietal region (Pz), which agree with the current findings of olfaction biophysics. Comparison with existing methods: We compared the performance of our method with that of four existing methods in the literature. Our method outperformed these four methods. Moreover, our method elicited the highest accuracy when the clinical olfactory score (UPSIT) was included as a feature. Conclusions: Our analysis framework reveals a significant alteration of the timing organization of the brain that emerged upon olfactory stimulation in Alzheimer's patients. The timings of characteristic response and the features calculated via these timings contribute to Alzheimer's disease diagnosis performance remarkably. The perspective proposed here may facilitate early diagnosis, thereby facilitating the exploration of novel therapeutic and treatment strategies.Article Citation - WoS: 2Citation - Scopus: 3Emerging Trends of Biohydrogen Ecosystem on Environmental Sustainability: a Case Study(Elsevier Sci Ltd, 2025) Goren, A. Yagmur; Dincer, IbrahimThe greatest threat to humanity is now considered climate change. Biomass as a renewable energy source is treated as one of the clean energy sources that help meet humanity's energy needs. In the transition to a new energy system based on renewable energies, biomass can be crucial. This paper particularly focuses on a new biohydrogen (bioH2) ecosystem development concept for communities to provide global and local sustainable and green energy, considering the biomass-to-bioenergy nexus. In this regard, the paper further discusses the different bioH2 ecosystem concepts and emerging trends where biomass and renewable resources are utilized for energy production. In addition, the bioenergy production potentials of different agricultural crop wastes are evaluated for different end-use purposes like electricity, heat, cogeneration, and transport. In parallel to its high bioenergy yield, the highest total energy (83,686.8 GJ) and gross electricity (4686.5 MWh) production values were observed for the olive cake waste. Moreover, the biomethane and bioethanol production potentials of the crop wastes are evaluated. The highest biomethane yield of 253.7 m3/ha with a total bioenergy production of 40,662.6 GJ was obtained for the maize stover waste, while its bioethanol production was 505.7 L/ha. Consequently, the bioH2 ecosystem with biomass utilization reveales as a sustainable and green way of providing future energy for communities owing to the great potential of crop wastes for bioenergy production.Article Citation - WoS: 1Citation - Scopus: 1Properties of Roman Structural Mortars in the Province of Asia (turkey)(Elsevier Sci Ltd, 2025) Tasci, Burcu; Boke, HasanIn this study, the properties of Roman structural mortars composed of lime and natural aggregates from twentythree archaeological sites in Western Anatolia were determined in order to understand whether there was a common production technology of lime mortars in the Roman Empire by making a comparison between Europe and Western Anatolia. Their basic physical and mechanical properties, raw material compositions, microstructural and hydraulic properties, mineralogical and chemical compositions of their lime binder and fine aggregates were identified by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy coupled with energy dispersive spectroscopy, thermal gravimetric analysis analyses, bulk density, total porosity and compressive strength of mortars. The results indicated that these mortars mortars were produced by combining fat or lean lime with coarse aggregates (quartz, tuff) and predominantly fine pozzolanic rhyolitic and dacitic tuff aggregates. The lime/aggregate ratios of the mortars generally exhibited a range of values between 1:4 and 1.5:1 by weight, which closely paralleled the lime/aggregate ratios in other Roman mortars published in literature. The presence of lime lumps within the mortar matrices, exhibiting a spongy texture, may suggest the use of the hot lime mixing method in the preparation of the mortars. The mortars are hydraulic, possessing compressive strengths comparable to those observed in natural hydraulic lime mortars (NHL2, NHL3.5 and NHL5 types). The results indicate that the production of structural mortars in the province of Asia was similar to that in other regions of the Roman Empire, although the raw materials are similar, small differences in raw material composition could be due to the use of local raw material sources. This may be evidence of a common lime mortar technology that deliberately used pozzolanic aggregates with almost pure lime throughout the Roman Empire.
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