Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 2Citation - Scopus: 6Immobilization of Olive Leaf Extract With Chitosan Nanoparticles as an Adjunct To Enhance Cytotoxicity(American Chemical Society, 2023) Özdamar, Burcu; Sürmeli, Yusuf; Şanlı Mohamed, GülşahWe immobilized the olive leaf extract (OLE) with chitosannanoparticles(CNPs) by optimizing the effect of various immobilization conditions,and OLE-loaded CNPs (OLE-CNPs) were then elaborately characterizedphysicochemically by scanning electron microscopy (SEM), Fourier transforminfrared (FT-IR) spectroscopy, dynamic light scattering (DLS), andatomic force microscopy (AFM). Under optimal conditions, CNPs wereable to accommodate the OLE with a loading capacity of 97.5%. Theresulting OLE-CNPs had a spherical morphology, and their average diameterwas approximately 100 nm. The cytotoxic influence, cell cycle distribution,and apoptosis stage of OLE and OLE-CNPs were analyzed on lung carcinoma(A549) and breast adenocarcinoma (MCF-7) cell lines. In an in vitrocytotoxic assay, IC50 values of OLE-CNPs were determinedto be 540 & mu;g/mL for A549 and 810 & mu;g/mL for MCF-7. Thetreatment of both A549 and MCF-7 with OLE-CNPs caused the highestcell arrest in G0/G1 in a dose-independent manner. OLE-CNPs affectedcell cycle distribution in a manner different from free OLE treatmentin both cancer cells. A549 and MCF-7 cells were predominantly foundin the late apoptosis and necrosis phases, respectively, upon treatmentof 1000 & mu;M OLE-CNPs. Our results suggest that CNPs enhance theutility of OLEs as nutraceuticals in cancer and that OLE-CNPs canbe utilized as an adjunct to cancer therapy.Conference Object Citation - WoS: 14Citation - Scopus: 16Drying of Olive Leaves in a Geothermal Dryer and Determination of Quality Parameters of Dried Product(Elsevier, 2019) Helvacı, Hüseyin Utku; Menon, Abhay; Aydemir, Levent Yurdaer; Korel, Figen; Gökçen Akkurt, GüldenIn this study, a cabinet type geothermal dryer was designed, operated and tested for drying olive leaves with minimum losses of phenolic content and antioxidant capacity by optimization of drying conditions. Two factors; face centered central composite design was applied and response surface methodology was used to optimize the drying conditions of olive leaves. The results indicate that phenolic content stability were mainly affected by air temperature, whereas antioxidant capacity is affected by both air temperature and velocity (p<0.05). The optimal drying conditions were found to be at 50°C of air temperature and 1 m/s of air velocity for the minimum losses of determined quality parameters, where 88.8% of phenolic content and 95.3% of antioxidant capacity were recovered.