Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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Institution Author: search.filters.institutionAuthor.Özçelik, SerdarPublisher: search.filters.publisher.IOP Publishing

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  • Article
    Citation - WoS: 3
    Citation - Scopus: 5
    Physically Unclonable Security Patterns Created by Electrospinning, and Authenticated by Two-Step Validation Method
    (IOP Publishing, 2022) Taşcıoğlu, Didem; Atçı, Arda; Taşcıoğlu, Didem; Özçelik, Serdar; Özçelik, Serdar; 04.01. Department of Chemistry; 01. Izmir Institute of Technology; 04. Faculty of Science
    Counterfeiting is a growing economic and social problem. For anticounterfeiting, random and inimitable droplet/fiber patterns were created by the electrospinning method as security tags that are detectable under UV light but invisible in daylight. To check the authenticity of the original security patterns created; images were collected with a simple smartphone microscope and a database of the recorded original patterns was created. The originality of the random patterns was checked by comparing them with the patterns recorded in the database. In addition, the spectral signature of the patterns in the droplet/fiber network was obtained with a simple and hand-held spectrometer. Thus, by reading the spectral signature from the pattern, the spectral information of the photoluminescent nanoparticles was verified and thus a second-step verification was established. In this way, anticounterfeiting technology that combines ink formula, unclonable security pattern creation and two-level verification is developed.
  • Article
    Citation - WoS: 22
    Citation - Scopus: 18
    Nuclear-Targeted Gold Nanoparticles Enhance Cancer Cell Radiosensitization
    (IOP Publishing, 2020) Pratx, Guillem; Özçelik, Serdar; 04.01. Department of Chemistry; 04. Faculty of Science; 01. Izmir Institute of Technology
    Radiation therapy aims to kill or inhibit proliferation of cancer cells while sparing normal cells. To enhance radiosensitization, we developed 40 nm-sized gold nanoparticles targeting the nucleus. We exploited a strategy that combined RGD and NLS peptides respectively targeting cancer cell and the nucleus to initiate cell-death activated by x-ray irradiation. We observed that the modified gold nanoparticles were either translocated in the nuclei or accumulated in the vicinity of the nuclei. We demonstrated that x-ray irradiation at 225 kVp energy reduced cell proliferation by 3.8-fold when the nuclear targeted gold nanoparticles were used. We determined that the radiation dose to have a 10% survival fraction was reduced from 11.0 Gy to 7.1 Gy when 10.0 mu g ml(-1)of the NLS/RGD/PEG-AuNP was incubated with A549 cancer cells. We conclude that the peptide-modified gold nanoparticles targeting the nucleus significantly enhance radiosensitization.