Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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  • Article
    A Cluster of Surprise Egg Toys as Designed Objects at the Intersection of Design and Culture [2]
    (Common Ground Research Networks, 2022) Talu, N.
    This study examines the cultural context of a cluster of surprise egg toys. The cluster contains 167 toys, collected between the years 1993 and 2015. The study methodology consisted of content analysis involving both qualitative interpretation and quantitative techniques. The interpretation is initiated with the toys’ physical materiality. Analysis is then developed on the compositional modalities of each toy, the place of each in the cluster, and the cluster as a whole. Qualitative interpretation and theoretical analysis of detailed descriptions and groupings of the cluster highlight the central themes found at the intersection of design and culture. Analysis of the cluster reveals that it carries the duality, or the tension, between modern and postmodern cultures with one elevating functionality and the other using storytelling as a means of creativity. They are designed objects and design things blending the two cultures in their physical content, and can be seen as artifacts that contribute to the value of design in everyday life within the context of mass culture. © Common Ground Research Networks, Nilüfer Talu, All Rights Reserved.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    Synthesis, Cytotoxicity, and Antibacterial Studies of 2,4,5,6-Substituted Hexahydro-1h
    (Wiley, 2023) Yetişkin, Egehan; Gündoğdu, Özlem; Mete, Derya; Celebioglu, Neslihan; Kara, Yunus; Şanlı-Mohamed, Gulsah
    In this study, synthesis of novel isoindole-1,3-dione analogues bearig halo, hydroxy, and acetoxy groups at the position 4,5,6 of the bicyclic imide ring was performed to examine their potential anticancer effects against some cell lines. A multistep chemical pathway was used to synthesize the derivatives. The cytotoxic effect of trisubstituted isoindole derivatives were evaluated by determining cellular viability using the MTT assay against A549, PC-3, HeLa, Caco-2, and MCF-7 cell lines. The C-2 selective ring-opening products were obtained from the ring-opening reaction of 5-alkyl/aryl-2-hydroxyhexahydro-4H-oxireno[2,3-e]isoindole-4,6(5H)-diones with nucleophiles such as chloride (Cl-) and bromide (Br-) ions. In addition, the ring-opening products halodiols were converted to their related acetates. The anticancer activity of synthesized isoindole-1,3-dione derivatives was investigated against HeLa, A549, MCF-7, PC3, and Caco-2 cells in vitro and resulted in varies cytotoxic effect depend on the group attached to the isoindole molecule. Furthermore, the evaluation of the antimicrobial action of trisubstituted isoindole derivatives against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria was assessed and found out selective inhibition of the both bacterial growth via different trisubstituted isoindole derivatives. The results of this work encourage further research on the potential utilization of trisubstituted isoindole derivatives as cytotoxic and antimicrobial agents.