Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 7Citation - Scopus: 8Ascorbic Acid Enhances the Metabolic Activity, Growth and Collagen Production of Human Dermal Fibroblasts Growing in Three-Dimensional (3D) Culture(Gazi Üniversitesi, 2023) Dikici, Serkan; Dikici, Serkan; 03.01. Department of Bioengineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyTissue engineering (TE) enables the development of functional synthetic substitutes to be replaced with damaged tissues and organs instead of the use of auto or allografts. A wide range of biomaterials is currently in use as TE scaffolds. Among these materials, naturally sourced ones are favorable due to being highly biocompatible and supporting cell growth and function, whereas synthetic ones are advantageous because of the high tunability on mechanical and physical properties as well as being easy to process. Alongside the advantages of synthetic polymers, they mostly show hydrophobic behavior that limits biomaterial-cell interaction and, consequently, the functioning of the developed TE constructs. In this study, we assessed the impact of L-Ascorbic acid 2-phosphate (AA2P) on improving the culture conditions of human dermal fibroblasts (HDFs) growing on a three-dimensional (3D) scaffold made of polycaprolactone (PCL) using emulsion templating. Our results demonstrated that AA2P enhances the metabolic activity and growth of HDFs as well as collagen deposition by them when supplemented in their growth medium at 50 µg/mL concentration. It showed a great potential to be used as a growth medium supplement to circumvent the disadvantages of culturing human cells on a synthetic biomaterial that is not favored in default. AA2P's potential to improve cell growth and collagen deposition may prove an effective way to culture human cells on 3D PCL PolyHIPE scaffolds for various TE applications.Article Eğitim yapılarında asansör trafik analizi yöntemlerinin karşılaştırılmasına yönelik bir araştırma(Gazi Üniversitesi, 2023) Deligöz, Dostcan; Harputlugil, Timuçin; 01. Izmir Institute of TechnologyPurpose: Regarding elevator design in educational buildings; It is aimed to investigate the legal framework, to integrate dynamic simulation programs to design process, to compare traditional and dynamic simulation methods, to evaluate the adequacy of elevator features specified in the legislation and to determine the optimum scenarios according to the minimum requirements.Theory and Methods: Based on the findings of the literature review, which examines the issue of elevator traffic analysis together with the legislation and regulations, the carrying capacities of the elevators in the educational buildings designed by the Ministry of National Education (MNE) are tested. The stability of the system is tested by analyzing the conditions where only the disabled, disabled and building workers can be used together and all building users can use the elevators with the dynamic simulation method (with Elevate Software). The limits of the system are determined based on the waiting times during the peak usage periods. The findings of the study are evaluated according to the waiting times determined by CIBSE Guide D and the Chamber of Mechanical Engineers followed by the discussion of the outcomes.Results: The issue of elevator design has been overlooked in educational buildings, and a comprehensive elevator traffic analysis method has not been defined. For the effective use of all occupants, elevator design should be handled comprehensively with considering potentials of dynamic simulation method.Conclusion: According to the findings of the study, it is noted that the number and capacity of elevators in the legislation for educational buildings are determined only for minimum conditions and for disabled users. In addition, the legislation (considering calculation methodology) is not specific for educational buildings but related with buildings in general with public use. Considering the occupants, and their profiles of the educational buildings, a more comprehensive traffic analysis with the dynamic simulation method may enable the elevators to be designed and to be used more efficiently.Article Citation - WoS: 1Citation - Scopus: 1Fragility Analysis of Wide-Beam Infill-Joist Block Rc Frames(Gazi Üniversitesi, 2022) Dönmez, Cemalettin; Dönmez, Cemalettin; Erberik, Murat Altuğ; 03.03. Department of Civil Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyPurpose: The purpose of the presented study is to develop fragility curves for the wide-beam infill-joist block reinforced concrete structures. Theory and Methods: Nonlinear time history analyses are performed for the set of selected ground motions. The performance levels are identified through pushover analysis and fragility curves are produced for ground motion parameters. Results: Fragility curves obtained for the wide-beam RC frames presents a different characteristic than the curves obtained for the conventional frames. Conclusion: Results show that wide-beam RC frame buildings are seismically more vulnerable than the conventional deep beam RC frame buildings based on structural models with similar properties. The possible reason seems to be low lateral stiffness of wide-beam frames that causes large lateral drift demands and therefore severe damage at the wide-beam column connections.Article Citation - WoS: 11Citation - Scopus: 12Effect of Process Parameters on Surface Quality for Wire Saw Cutting of Alumina Ceramic(Gazi Üniversitesi, 2011) Teomete, Egemen; 01. Izmir Institute of TechnologySilicon wafers are sliced using wire saw in micro electronics and photo voltaic industries. Wire saw process occupies a great portion of silicon wafer production cost which affects the market directly. The process is also used to cut ceramics, concrete and rocks in civil engineering. The high cost of the process motivates researchers to develop models that will relate the process efficiency and quality with process parameters. In this study, an experimental parametric study was conducted to investigate the effect of process parameters on the wire bow angle, distributed wire load and surface roughness in wire saw cutting of alumina ceramic. The material removal and surface damage formation mechanisms are identified. Process design recommendations for increasing efficiency of the process while keeping the surface roughness constant, are presented. The surface roughness increases with increasing feed rate, decreases with wire speed and is independent of wire tension. The material is removed by trans-granular failure of the grains while inter-granular fractures of the grains affect the surface quality.Article Citation - WoS: 3Citation - Scopus: 3Particulate Sol Route Hydroxyapatite Thin Film-Silk Protein Interface Interactions(Gazi Üniversitesi, 2010) Özcan, Selçuk; Çiftçioğlu, Muhsin; Çiftçioğlu, Muhsin; 03.02. Department of Chemical Engineering; 03. Faculty of Engineering; 01. Izmir Institute of TechnologyHydroxyapatite (HAp) thin film coatings were prepared on bioinert glass slides by a particulate sol method and the effects of intermediate silk fibroin and silk sericin coatings on the HAp film formation and surface topography were examined. The films prepared with smaller crushed particle sols had a higher agglomeration tendency during the drying consolidation step of the thin film formation, and contained agglomerates larger in number and size, which was demonstrated experimentally and in accordance with the DLVO theory. In the thin films prepared on intermediate sericin and fibroin films the number and size of agglomerates were decisively reduced, forming homogeneous films of predominantly primary particles, especially for the larger particle size sols. The regular surface electrostatic potential arrangements of the β-sheet structures of the sericin and fibroin, and of hydroxyapatite crystals, gave rise to the coulombic attraction driven surface energy minimization, enhancing the hydroxyapatite thin film formation process. The positive degree of cooperativity in the hydroxyapatite particle deposition on the silk protein coatings was disrupted by the particle agglomeration tendency.