Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
Browse
7 results
Search Results
Article Cx32 Cellular Localization Is Related To Epithelial To Mesenchymal Transition in Breast Cells(Pleiades Publishing inc, 2025) Oz, Sercan; Turan, Fatma Basak; Yondem, Eyup; Pesen-Okvur, Devrim; Yalcin-Ozuysal, Ozden; Ozcivici, Engin; Mese, GulistanConnexins (Cx) play both gap junction-related and -independent roles in cells, and their localization is essential for their function in cellular processes. Besides membrane localization, connexins can also be localized to the cytoplasm and nucleus, especially in cancer cells. The differential localization of connexins including Cx32 was observed in different stages of cancers. Cx32 was upregulated and observed in cytoplasms of cells in lymph-node metastasis of breast cancer samples compared to primary tumors. However, the significance of the increase in Cx32 expression and alteration of Cx32 cellular localization in epithelial-to-mesenchymal transition (EMT) is not known. To determine if Cx32 overexpression and/or localization over one week would induce the EMT process, we first examined the cellular localization of Cx32 in MCF10A and MDA-MB-231 cells at different time points using Western blot and RT-PCR as well as immunostaining with confocal microscopy. Then, we correlated the changes of Cx32 expression and localization with EMT marker expression. We showed that Cx32 had altered cellular localization and Cx32 overexpression increased Slug levels while it reduced E-cadherin and Snail expression in MDA-MB-231 for 7 days. In contrast, E-cadherin and Vimentin were reduced in MCF10A-Cx32 cells compared with controls over 7 days, and the expression pattern for nuclear Cx32 and Zeb2 was following similar pattern in MCF10A cells. Our results suggest a previously unknown time-dependent relation between Cx32 and the regulation of the EMT process.Article Citation - WoS: 1Citation - Scopus: 1An Iris Segmentation Scheme Based on Bendlets(Springer London Ltd, 2023) Aghazadeh, Nasser; Abbasi, Mandana; Noras, ParisaDue to the effect of agents such as ambiance, transition channel, and other agents, images are polluted by noise during collection, transition, and compaction, leading to decrease image quality. Noise can decrease the accuracy of the next stages of image processing systems. Therefore, one of the vital stages in the novel processing systems is denoising. This article offers a novel image denoising approach using bendlets. Other multi-scale transformations (such as wavelets, curvelets, and shearlets) cannot recognize properties such as location, direction, and curvature of discontinuities well in piecewise stable images. To solve this problem, bendlets are suggested in this article. Bendlets differ from other multi-scale transformations in that an additional bending parameter is utilized for recognizing the curvature of discontinuities. Bendlets need a fewer number of coefficients to identify curvatures than other multi-scale transformations. Furthermore, they help to make the edges more obvious. The suggested approach is utilized on the UBIRIS.V2 database. It earns better accuracy and stability than other multi-scale transformations.Conference Object Citation - Scopus: 8Localization of a Passive Molecular Transmitter With a Sensor Network(Springer, 2020) Güleç, Fatih; Atakan, BarışMacroscale molecular communication (MC), which has a potential for practical applications, is a promising area for communication engineering. In a practical scenario such as monitoring air pollutants released from an unknown source, it is essential to estimate the location of the molecular transmitter (TX). This paper presents a novel Sensor Network-based Localization Algorithm (SNCLA) for passive transmission by using a novel experimental platform which mainly comprises a clustered sensor network (SN) with 24 sensor nodes and evaporating ethanol molecules as the passive TX. With the usage of the SN concept, novel methods can be developed for the problems in macroscale MC by utilizing the wide literature of sensor networks. In SNCLA, Gaussian plume model is employed to derive the location estimator. The parameters such as transmitted mass, wind velocity, detection time and actual concentration are calculated or estimated from the measured signals via the SN to be employed as the input for the location estimator. The numerical results show that the performance of SNCLA is better for stronger winds in the medium. Our findings show that evaporated molecules do not propagate homogeneously through the SN due to the presence of the wind. In addition, the estimation error of SNCLA decreases for higher detection threshold values. © 2020, ICST Institute for Computer Sciences, Social Informatics and Telecommunications Engineering.Article Citation - WoS: 19Citation - Scopus: 24Intracytoplasmic Re-Localization of Mirisc Complexes(Frontiers Media S.A., 2018) Akgül, Bünyamin; Erdoğan, İpekMicroRNAs (miRNAs) are a conserved class of non-coding RNAs of 22 nucleotides that post-transcriptionally regulate gene expression through translational repression and/or mRNA degradation. A great progress has been made regarding miRNA biogenesis and miRNA-mediated gene regulation. Additionally, an ample amount of information exists with respect to the regulation of miRNAs. However, the cytoplasmic localization of miRNAs and its effect on gene regulatory output is still in progress. We provide a current review of the cytoplasmic miRNA localization in metazoans. We then discuss the dynamic changes in the intracytoplasmic localization of miRNAs as a means to regulate their silencing activity. We then conclude our discussion with the potential molecules that could modulate miRNA localization.Article Citation - WoS: 5Citation - Scopus: 5Defect Induced Anderson Localization and Magnetization in Graphene Quantum Dots(Elsevier, 2018) Altıntaş, Abdulmenaf; Güçlü, Alev DevrimWe theoretically investigate the effects of atomic defect related short-range disorders and electron-electron interactions on Anderson type localization and the magnetic properties of hexagonal armchair graphene quantum dots using an extended mean-field Hubbard model and wave packet dynamics for the calculation of localization lengths. We observe that randomly distributed defects with concentrations between 1 and 5% of the total number of atoms leads to localization alongside magnetic puddle-like structures. Although the localization lengths are not affected by interactions, staggered magnetism and localization are found to be enhanced if the defects are distributed unevenly between the sublattices of the honeycomb lattice.Article Citation - Scopus: 1Cost Effective Localization in Distributed Sensory Networks(Elsevier Ltd., 2011) Coşkun, Anıl; Sevil, Hakkı Erhan; Özdemir, SerhanThe most important mechanism to occur in biological distributed sensory networks (DSNs) is called lateral inhibition, (LI). LI relies on one simple principle. Each sensor strives to suppress its neighbors in proportion to its own excitation. In this study, LI mechanism is exploited to localize the unknown position of a light source that illuminated the photosensitive sensory network containing high and low quality sensors. Each photosensitive sensor was then calibrated to accurately read the distance to the light source. A series of experiments were conducted employing both quality sensors. Low quality array was allowed to take advantage of LI, whereas the high quality one was not. Results showed that the lateral inhibition mechanism increased the sensitivity of inferior quality sensors, giving the ability to make the localization as sensitive as high quality sensors do. This suggests that the networks with multitude of sensors could be made cost-effective, were these sensory networks equipped with LI.Conference Object Citation - WoS: 1Citation - Scopus: 1The Newton-Wigner Localization Concept and Noncommutative Space(Springer Verlag, 2005) Mir-Kasimov, Rufat M.In the formulation of the Newton-Wigner postulates for the relativistic localized states the hypothesis of commutativity of the position operator components is silently accepted as an evident fact. In the present work it is shown that commutativity is not necessary condition and the alternative (noncommutative) approach to the relativistic position operator and localization concept can be realized in a framework of the physically as well as mathematically comprehensive scheme.