Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Design Strategies to Optimize Polymeric Vectors for mRNA Delivery(Taylor and Francis Ltd., 2025) Turhan, Z.Y.; Savaş, M.; Alakbarov, A.; Bulmus, V.mRNA holds great promise for preventing and treating a variety of diseases, from infectious diseases to diverse cancers, owing to its transient expression, lack of genomic integration, and scalable production. Among non-viral vectors, polymeric carriers are attractive due to their synthetic versatility and stability, which allow for precise tuning for efficient mRNA delivery. Their scalability further supports the applicability of polymeric vectors. Studies have addressed the room for improvement in polymeric systems for mRNA delivery and have adapted varying approaches depending on the type of polymeric structure, including but not limited to PEGylation, hydrophobic modification, and incorporation of responsive or targeting moieties. This review summarizes advances in polymeric vectors for mRNA delivery and highlights how distinct structural modifications influence toxicity, mRNA transfection efficiency, biodistribution, intracellular trafficking and immune activation, providing a framework for the rational design of next-generation polymeric vectors that can fully realize the clinical potential of mRNA therapeutics. © 2025 Taylor & Francis Group, LLC.Article Industrial History and Heritage of the Karaburun Mercury Mining District, Türkiye(Taylor and Francis Ltd., 2025) Yılmazer, Aslıhan; Gönülal, Yasemin Özcan; Yüceer, HülyaMining metallic resources has been important to technological advancement since prehistoric times and has contributed to the progress of civilisation. Mining heritage includes sites and structures related to mining that reveal historical and cultural insights. The remains of structures in the mercury mining district on the Karaburun peninsula of Izmir in Türkiye, which includes the Kalecik, Karareis and Dikencik mines, is one such site. Despite its abandonment and subsequent damage, research has highlighted the importance of the district during the late Ottoman empire and the early years of the Republic as a source of cinnabar, the most common source ore for refining elementary mercury. Comparable mines elsewhere have been transformed into heritage sites and tourist attractions, such as at Monte Amiata in Italy and Idrija in Slovenia. In view of the potential, this study aimed to establish the historical and industrial significance of the Karaburun mercury mining district through detailed research and site survey to form a robust base for a holistic conservation approach. © 2025 Elsevier B.V., All rights reserved.Article Citation - WoS: 1Citation - Scopus: 1Optimized Lithium(I) Recovery From Geothermal Brine of Germencik, Türkiye, Utilizing an Aminomethyl Phosphonic Acid Chelating Resin(Taylor and Francis Ltd., 2025) Recepoğlu, Y.K.This study investigates the performance of Lewatit TP 260 ion exchange resin for the efficient recovery of lithium (Li(I)) from geothermal water sourced from the Germencik Geothermal Power Plant in Türkiye. A series of batch sorption experiments were performed to evaluate the influence of key parameters, including resin dosage, solution pH, temperature, initial Li(I) concentration, and contact time, on the Li(I) recovery process. The optimal conditions were determined to be a resin dose of 0.5 g per 25 mL of geothermal water, pH in the range of 6–8, and a temperature of 25°C. Under these conditions, the resin achieved a maximum Li(I) recovery rate of 71% from the geothermal water. Sorption isotherms were further analyzed using the Langmuir, Freundlich, and Dubinin-Radushkevich (D-R) models. Among these, the Langmuir model provided the best fit (R² = 0.9841), suggesting a maximum sorption capacity (qm) of 4.31 mg/g. Continuous recovery experiments conducted in column mode confirmed the practical applicability of Lewatit TP 260, achieving a total sorption capacity of 0.41 mg Li(I)/mL resin. The findings exhibit the potential of this resin as a viable sorbent for sustainable Li(I) extraction from geothermal brines, supporting the development of green energy technologies and contributing to the circular economy. © 2024 Taylor & Francis Group, LLC.Article Effects of Span 60 Template and Freeze Drying on Zinc Borate Produced From Zinc Nitrate Hexahydrate and Borax Decahydrate(Taylor and Francis Ltd., 2022) Alp, Burcu; Gönen, Mehmet; Atakul Savrık, Sevdiye; Balköse, DevrimZinc borate is an important additive to polymers and lubricants. The process variables such as reactant concentration, presence of template in precipitating medium and drying method determine the composition and particle size of zinc borates. In the present study, zinc borate precipitate obtained by mixing aqueous zinc nitrate and borax decahydrate solutions was dried either by conventional method or by freeze drying. The products were well characterized by advanced methods. Zinc borate from 1 mol dm(-3) reactants had (2.1 +/- 0.5)x(2.5 +/- 0.5)x(1.3 +/- 0.2) mu m and (0.5 +/- 0.1)x(1.3 +/- 0.1)x(0.028 +/- 0.01) mu m dimensions by conventional and freeze drying respectively. Individual particles smaller in size is obtained since the particles are not agglomerated due to absence of surface tension of liquid water for case of freeze drying. Planar particles agglomerated into 20 to 60 mu m crystals in the presence of template Span 60 in 1 mol dm(-3) reactants for conventional drying. Nano zinc borate particles with primary particle size of (46 +/- 9) nm were obtained by decreasing the reactant concentration to 0.1 mol dm(-3). The primary particle size was decreased to (40 +/- 3) nm by addition of Span 60 to dilute solutions. However zinc borate nanoparticles obtained from dilute solutions adhered to each other forming agglomerates during conventional drying. Their freeze drying would allow formation of a freely flowing nano powder.Article Citation - WoS: 2Citation - Scopus: 2A New Fluorescent 'turn On' Probe for Rapid Detection of Biothiols(Taylor and Francis Ltd., 2020) Üçüncü, Muhammed; Zeybek, Hüseyin; Karakuş, Erman; Üçüncü, Canan; Emrullahoğlu, MustafaWe designed and synthesised a novel molecular probe exhibiting high selectivity and sensitivity towards reactive sulphur species (RSS) over other amino acids and biologically relevant species, as well as scrutinised its spectroscopic behaviours under physiological conditions and in living milieu. We used an electrophilic cyanate group as a masking agent to block the excited state intramolecular proton transfer process of 2-(2-cyanato-3-methoxyphenyl)benzo[d]thiazole (HMBT-OCN), which readily hydrolyses to the highly fluorescent structure, 2-(2'-Hydroxy-3'-methoxyphenyl) benzothiazole (HMBT-OH), in the presence of reactive sulphur species. [GRAPHICS] .Article Citation - WoS: 7Citation - Scopus: 11Chemical Composition and Biological Activities of Cypriot Propolis(Taylor and Francis Ltd., 2021) Nalbantsoy, Ayşe; Sarıkahya, Nazlı Böke; Özverel, Cenk Serhan; Barlas, Ayşe Berçin; Kırcı, Damla; Akgün, İsmail Hakkı; Yalçın, Tansel; Güven, Gamze; Kışla, Duygu; Demirci, Betül; Topçu, Gülaçtı; Gören, Ahmet CeyhanPropolis compositions are highly variable, depending on the geographic region and the season of collection. In this study, propolis samples from seven different regions of Cyprus were studied for the first time by means of chemical content and biological activities. Secondary metabolite composition was determined by LC-HRMS. While the major flavonoids found were isosakuranetin, naringenin, rhamnocitrin, diosmetin, chrysin and acacetin, interestingly verbascoside, a phenylethanoid glycoside, and chlorogenic acid were identified as the major compounds in the ethanol-water extracts. alpha-Pinene was detected as the major compound of propolis extracts according to the volatile compositions via GC-MS. Karaoglanoglu and Tirmen extracts, presenting different chemical profiles, exerted enormous cytotoxic activity by MTT assay (IC50: 2.36-11.56 mu g/mL; 1.44-9.33 mu g/mL, respectively). The highest iNOS inhibition potential was detected in the Karpaz extract (IC50:2.6 mu g/mL) in LPS induced RAW 264.7 cells whereas the Guzelyurt sample demonstrated remarkable antioxidant (88.82 +/- 0.10%) and antimicrobial activities (with a MIC value of 31.2 mu g/mL against S. aureus, S. epidermidis, E. faecium, and E. faecalis).Article Citation - WoS: 1Citation - Scopus: 2Consolidation of a Bath Ruin in an Archaeological Site(Taylor and Francis Ltd., 2022) Durmuşlar, Feyza; Turan, Mine; Yücetürk, Kutay; Aktaş, EnginThe study has focused on consolidation of a historical bath ruin in an archaeological site. Cevher Pasa Bath, which is located in Tabae archaeological site in Denizli, Turkey and dated to the 15th century, presents structural problems. The aim of the study is to propose a framework for planning consolidation of the ruins of Cevher Pasa Bath so that conservation work regarding similar masonry ruins in archaeological sites can be guided. Thus, methods of architectural restoration and civil engineering are combined in an interdisciplinary scope. Provision of temporary shoring as an emergency intervention, consolidation and presentation of the ruin within the scope of an interdisciplinary restoration project, and monitoring of the asset within the frame of a monument management plan are suggested, respectively. Structural analysis considering stress and overturning moment checks are performed. Consolidation work includes only supporting of arch remains. Some walls of the ruin are weaker than other parts. These parts need further detailed analysis, and if necessary, further consolidation and strengthening are to be carried out. The monument management plan points out the necessity of collaboration of local and central administrations, and also non-governmental organisations.Article Citation - WoS: 5Citation - Scopus: 5On simple-direct modules(Taylor and Francis Ltd., 2021) Büyükaşık, Engin; Demir, Özlem; Diril, MügeRecently, in a series of papers “simple” versions of direct-injective and direct-projective modules have been investigated. These modules are termed as “simple-direct-injective” and “simple-direct-projective,” respectively. In this paper, we give a complete characterization of the aforementioned modules over the ring of integers and over semilocal rings. The ring is semilocal if and only if every right module with zero Jacobson radical is simple-direct-projective. The rings whose simple-direct-injective right modules are simple-direct-projective are fully characterized. These are exactly the left perfect right H-rings. The rings whose simple-direct-projective right modules are simple-direct-injective are right max-rings. For a commutative Noetherian ring, we prove that simple-direct-projective modules are simple-direct-injective if and only if simple-direct-injective modules are simple-direct-projective if and only if the ring is Artinian. Various closure properties and some classes of modules that are simple-direct-injective (resp. projective) are given. © 2020 Taylor & Francis Group, LLC.Correction Corrigendum To “ankos Publisher Application System and Its Impact on the E-Resource Evaluation Process” [serials Review 39 (2013) 29–36](Taylor and Francis Ltd., 2013) Bulut, Burcu; Uğur, Handan; Gürdal, Gültekin; Holt, İlkay; Çukadar, Sami; Akbayrak, Emre H.; Çelebi, Mustafa K.[No abstract available]Conference Object Detection of Urban Change Using Remote Sensing and Gis: Izmir Case(Taylor and Francis Ltd., 2008) Tarhan, Çiğdem; Arkon, Cemal; Çelik, M.; Gümüştekin, Şevket; Tecim, V.This study is an example of how land use changes could be detected via high resolution remotely sensed data. In order to perform "change detection" IKONOS satellite images, belonging to 2001 and 2004, have been used. An automated Graphical User Interface (GUI) has been created for detection of environment. Different image enhancement techniques and a fuzzy inference system have been combined in the GUI. The detection results are classified according to some basic levels such as 20-50% and 70%. Additionally, four different change detection algorithms have been applied which are pixel-based, object based, feature based. These algorithms have been examined according to change detection levels with different image enhancement techniques. At the end of the study, the results have been compared.