Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 4Citation - Scopus: 4Mobile human ad hoc networks: A communication engineering viewpoint on interhuman airborne pathogen transmission(Elsevier, 2022) Güleç, Fatih; Atakan, Barış; Dressler, FalkoA number of transmission models for airborne pathogens transmission, as required to understand airborne infectious diseases such as COVID-19, have been proposed independently from each other, at different scales, and by researchers from various disciplines. We propose a communication engineering approach that blends different disciplines such as epidemiology, biology, medicine, and fluid dynamics. The aim is to present a unified framework using communication engineering, and to highlight future research directions for modeling the spread of infectious diseases through airborne transmission. We introduce the concept of mobile human ad hoc networks (MoHANETs), which exploits the similarity of airborne transmission-driven human groups with mobile ad hoc networks and uses molecular communication as the enabling paradigm. In the MoHANET architecture, a layered structure is employed where the infectious human emitting pathogen-laden droplets and the exposed human to these droplets are considered as the transmitter and receiver, respectively. Our proof-of-concept results, which we validated using empirical COVID-19 data, clearly demonstrate the ability of our MoHANET architecture to predict the dynamics of infectious diseases by considering the propagation of pathogen-laden droplets, their reception and mobility of humans.Article Citation - WoS: 6Citation - Scopus: 6A Comparative Study of Hplc and Uv Spectrophotometric Methods for Oseltamivir Quantification in Pharmaceutical Formulations(Akademiai Kiado, 2022) Güngör, Serdar; Bulduk, İbrahim; Aydın, Beyza Sultan; İlikçi Sağkan, RahşanOseltamivir is an antiviral drug and is used in the treatment of all influenza viruses. It is the most effective antiviral option against all influenza viruses that can infect humans. UV and LC methods have been developed and validated according to ICH guidelines for various parameters like selectivity, linearity, accuracy, precision, LOD and LOQ, robustness for the quantitative determination of oseltamivir in pharmaceutical formulations. LC method has been performed using reverse phase technique on a C-18 column with a mobile phase consisting of 20 mM potassium dihydrogen phosphate solution and acetonitrile (60:40, v/v) at 25 8C. The mobile phase flow rate was 1.2 mL min-1. For the determination of oseltamivir, UV spectrum has been recorded between 200 and 800 nm using methanol as solvent and the wavelength of 215 nm has been selected. Both methods have demonstrated good linearity, precision and recovery. No spectral and chromatographic interferences from the capsule excipients were found in UV and LC methods. In both methods, correlation coefficients were greater than 0.999 within a concentration range of 10???60 mg mL-1 using UV and LC. Intra-day and inter-day precision with low relative standard deviation values were observed. The accuracy of these methods was within the range 99.85???100.17% for LC and from 99.26 to 100.70% for UV. Therefore UV and LC methods gave the most reliable outcomes for the determination of oseltamivir in pharmaceutical formulation.Article Citation - WoS: 11Citation - Scopus: 11The Importance of Neopterin in Covid-19: The Prognostic Value and Relation With the Disease Severity(Elsevier, 2022) Rasmi, Yousef; Heidari, Nadia; Kübra Kırboğa, Kevser; Hatamkhani, Shima; Tekin, Burcu; Alipour, Shahryar; Naderi, Roya; Farnamian, Yeghaneh; Akça, İlknurCoronavirus Disease 2019 [COVID-19], caused by severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2], has rapidly evolved into a global health emergency. Neopterin [NPT], produced by macrophages when stimulated with interferon [IFN-]gamma, is an essential cytokine in the antiviral immune response. NPT has been used as a marker for the early assessment of disease severity in different diseases. The leading cause of NPT production is the pro-inflammatory cytokine IFN-. Macrophage activation has also been revealed to be linked with disease severity in SARS-CoV-2 patients. We demonstrate the importance of NPT in the pathogenesis of SARS-CoV-2 and suggest that targeting NPT in SARS-CoV-2 infection may be critical in the early prediction of disease progression and provision of timely management of infected individuals.Article Citation - WoS: 8Citation - Scopus: 9Analysis of Covid 19 Disease With Sir Model and Taylor Matrix Method(American Institute of Mathematical Sciences, 2022) Uçar, Deniz; Çelik, ElçinCovid 19 emerged in Wuhan, China in December 2019 has continued to spread by affecting the whole world. The pandemic has affected over 328 million people with more than 5 million deaths in over 200 countries which has severely disrupted the healthcare system and halted economies of the countries. The aim of this study is to discuss the numerical solution of the SIR model on the spread of Covid 19 by the Taylor matrix and collocation method for Turkey. Predicting COVID-19 through appropriate models can help us to understand the potential spread in the population so that appropriate action can be taken to prevent further transmission and prepare health systems for medical management of the disease. We deal with Susceptible–Infected–Recovered (SIR) model. One of the proposed model’s improvements is to reflect the societal feedback on the disease and confinement features. We obtain the time dependent rate of transmission of the disease from susceptible β(t) and the rate of recovery from infectious to recovered γ using Turkey epidemic data. We apply the Taylor matrix and collocation method to the SIR model with γ, β(t) and Covid 19 data of Turkey from the date of the first case March 11, 2020 through July 3, 2021. Using this method, we focus on the evolution of the Covid 19 in Turkey. We also show the estimates with the help of graphics and Maple.Article Citation - WoS: 37Citation - Scopus: 48Microfluidic-Based Virus Detection Methods for Respiratory Diseases(Springernature, 2021) Tarım, Ergün Alperay; Karakuzu, Betül; Öksüz, Cemre; Sarıgil, Öykü; Kızılkaya, Melike; Al-Ruweidi, Mahmoud Khatib A. A.; Yalçın, Hüseyin Çağatay; Özçivici, Engin; Tekin, Hüseyin CumhurWith the recent SARS-CoV-2 outbreak, the importance of rapid and direct detection of respiratory disease viruses has been well recognized. The detection of these viruses with novel technologies is vital in timely prevention and treatment strategies for epidemics and pandemics. Respiratory viruses can be detected from saliva, swab samples, nasal fluid, and blood, and collected samples can be analyzed by various techniques. Conventional methods for virus detection are based on techniques relying on cell culture, antigen-antibody interactions, and nucleic acids. However, these methods require trained personnel as well as expensive equipment. Microfluidic technologies, on the other hand, are one of the most accurate and specific methods to directly detect respiratory tract viruses. During viral infections, the production of detectable amounts of relevant antibodies takes a few days to weeks, hampering the aim of prevention. Alternatively, nucleic acid-based methods can directly detect the virus-specific RNA or DNA region, even before the immune response. There are numerous methods to detect respiratory viruses, but direct detection techniques have higher specificity and sensitivity than other techniques. This review aims to summarize the methods and technologies developed for microfluidic-based direct detection of viruses that cause respiratory infection using different detection techniques. Microfluidics enables the use of minimal sample volumes and thereby leading to a time, cost, and labor effective operation. Microfluidic-based detection technologies provide affordable, portable, rapid, and sensitive analysis of intact virus or virus genetic material, which is very important in pandemic and epidemic events to control outbreaks with an effective diagnosis.Article Citation - WoS: 2Citation - Scopus: 3Meta-Synthesis of Covid-19 Lessons: Charting Sustainable Management of Future Pandemics(Routledge, 2021) Ziafati Bafarasat, AbbasDevelopment of the COVID-19 vaccines has been creating a lot of hope for an ultimate return to normality, but returning to normality as we had before would mean we will continue to ignore life-ravaging lessons, as we did for severe acute respiratory syndrome, Ebola, and Middle East respiratory syndrome. This meta-synthesis of COVID-19 lessons charts sustainable pandemic management in terms of choosing strategies that are situated in their contextual specifications and beginning preparations for future application of such strategies from now. To guide selection of a situated strategy, the paper provides a comprehensive list of epidemiological determinants (e.g. communicativeness, poverty, supply chain, density, wind, remoteness); consolidates knowledge about strategies of elimination, suppression and mitigation; and proposes a quantified SWOT analysis of epidemiological determinants that produces coordinates for strategy identification in a Cartesian plane divided into twelve strategy quarters. To guide prior preparations for future application of pandemic management strategies, the paper consolidates lessons learned in implementation of situated strategies and proposes preparations at the national level for elimination, at the local/community level for suppression, and at the regional level for mitigation. Highlights: Lessons of COVID-19 (coronavirus) chart sustainable management of future pandemics. Epidemiological determinants and their mechanisms of impact are listed. Knowledge about elimination, suppression and mitigation strategies is consolidated. A quantified SWOT and Cartesian plane enable selecting context-specific strategies. Preparations for future elimination, suppression and mitigation are listed