Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    Frequency and Levels of Potential Drug-Drug Interactions in Tuberculosis Patients of a Teaching Hospital in Pakistan
    (Colegio de Farmaceuticos de la Provincia de Buenos Aires, 2016) Uddin, Fayyaz; Khan, Nasar; Ghani, Shamsul; Khan, Saeed A.
    Polypharmacy in tuberculosis is used to prevent occurrence of resistance to mycobacteria. However, drug-drug interaction is one of the undesirable consequences of polypharmacy, that may lead to ineffective medication or change in therapeutic response. The objective of the study was to identify prevalence, types and nature of potential drug-drug interactions in tuberculosis patients at Khyber Teaching Hospital, Peshawar Pakistan. Medical records of 409 randomly-selected patients were reviewed for pDDIs using Micromedex Database. Results show that total 304 interacting-combinations lead to 1437 potential drug-drug interactions. 87.5% of the these potential drug-drug interactions were of moderate and major severity (i.e., 65.6% and 44.3% respectively). With regards to scientific-evidence, almost 50% of the potential drug-drug interactions were good documented while 34.7% had fair level of documentation. Furthermore, we have listed some of the interacting drug combinations, particularly most frequent major and moderate interactions, will help health care professionals to review their established therapeutic strategy for tuberculosis patients in their clinical settings.
  • Article
    Citation - WoS: 31
    Citation - Scopus: 35
    Electrochemical Investigation of Biomolecular Interactions Between Platinum Derivatives and Dna by Carbon Nanotubes Modified Sensors
    (Elsevier Ltd., 2010) Yapaşan, Ece; Çalışkan, Ayfer; Karadeniz, Hakan; Erdem, Arzum
    The biomolecular interactions of platinum derivatives widely used as anticancer drugs: cis-diamminedichloroplatinum(II) and oxaliplatin with calf thymus double-stranded DNA were studied using differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) in combination with single-walled carbon nanotubes modified graphite electrode (SWCNTs-GE) and unmodified graphite electrode (bare GE). The performance of these biomolecular interactions were explored at the electrode surface by monitoring the changes at guanine oxidation signal in terms of optimum interaction times by comparing the results of SWCNTs-GE with bare one. The features of these electrochemical sensors based on carbon nanotubes for monitoring of biomolecular interactions were discussed and compared with the earlier conventional ones. © 2009 Elsevier B.V. All rights reserved.