Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 10Citation - Scopus: 11Intersection of Microrna and Gene Regulatory Networks and Their Implication in Cancer(Bentham Science Publishers B.V., 2014) Yousef, Malik; Trinh, Hung V.; Allmer, JensMicroRNAs (miRNAs) have attracted heightened attention for their role as post-transcriptional regulators of gene expression. It has become clear that miRNAs can both up- and downregulate protein expression. According to current estimates, most human genes are harboring miRNAs and/or are regulated by them. Thus miRNAs form a complex network of expression regulation which tightly interacts with known gene regulatory networks. Similar to some transcription factors, some miRNAs can have hundreds of target transcripts whose expression they modulate. Thus miRNAs can form complex regulatory networks by themselves, but because their expression is often tightly coordinated with gene expression, they form an intertwined regulatory network with many possible interactions among gene and miRNA regulatory pathways. In this review we first consider gene regulatory networks. Then we discuss microRNAs and their implication in cancer and how they may form regulatory networks. Finally, we give our perspective and provide an outlook including the aspect of personalized medicine.Conference Object Citation - WoS: 2Citation - Scopus: 4Symbolic Computation of Petri Nets(Springer, 2007) Iglesias, Andres; Kapçak, SinanPetri nets are receiving increasing attention from the scientific community during the last few years. They provide the users with a powerful formalism for describing and analyzing a variety of information processing systems such as finite-state machines, concurrent systems, multiprocessors and parallel computation, formal languages, communication protocols, etc. Although the mathematical theory of Petri nets has been intensively analyzed from several points of view, the symbolic computation of these nets is still a challenge, particularly for general-purpose computer algebra systems (CAS). In this paper, a new Mathematica package for dealing with some Petri nets is introduced.