Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 2Citation - Scopus: 3Evaluation of Hydro-Geochemical Processes Controlling Groundwater Quality in Balkh Center (Mazar-e-Sharif) Northern Afghanistan(Elsevier, 2025) Farahmand, Asadullah; Zaryab, Abdulhalim; Ameri, Nasrullah; Ali, Shakir; Eqrar, Mohammad NaimBackground: Groundwater in Afghanistan stands as the predominant water source employed for potable consumption, household utilization, irrigation, and industrial applications. Major cities of Afghanistan are largely dependent on groundwater resources. However, the groundwater quality of major cities in Afghanistan, including Mazar-e-Sharif city was not investigated in detail. Objective: This study aims to conduct a comprehensive analysis of the hydrochemical characteristics of the Mazare-Sharif groundwater, identify the factors influencing groundwater quality, and evaluate the groundwater contamination sources. Methods: A total of 18 groundwater samples were collected during the dry season (June 2020) and analyzed for various physico-chemical parameters. Methods such as multivariate statistical analyses, geochemical modeling, water quality index (WQI), and spatial distribution of groundwater quality were employed to evaluate the hydro-geochemistry of the study area. Results: The results reveal that 1) The prevailing groundwater within the study area is predominantly characterized by Na-(Ca)-HCO3 and Ca-(Mg)-SO4 water types. 2) Physicochemical variables such as NO3-, F-, TDS, and SO42-exceeded the World Health Organization (WHO) safe limits in many wells. 3) Hydro-geochemical processes such as silicate weathering, cation exchange, and gypsum dissolution controls the groundwater chemistry. 4) Cl/ Br ratios reveal, that high salinity may originate from evaporitic lacustrine and evaporite deposits and found to be localized in nature. 5) The Water Quality Index (WQI) classification suggests that approximately 60 % of the groundwater samples fall into poor to very poor water quality categories, highlighting substantial public health concerns. Major contaminants like nitrate and fluoride were found to be higher than the safe limit in nearly half of the samples. Conclusion: The findings of this study hold value for decision-makers in formulating a proficient strategy for the management of groundwater resources in Mazar-e-Sharif City in achieving the UN sustainable goal (SDG) of providing sustainable water for all. Furthermore, new advanced techniques like environmental isotopes should be analyzed to evaluate groundwater hydro-chemical evolution in the future to enhance our understanding.Article Understanding the Synthesis Mechanism of Arginine Functionalized Silver/Silver Chloride Nanoparticles Using Sugar Ligands(Elsevier, 2025) Bolat, Suheda; Degirmenci, Suna; Gumus, Abdurrahman; Sancak, Zafer; Yazgan, DrisIn this study, we performed a mechanistic study to understand how the sugar ligand chemistry affected the morphology, size and surface chemistry of Ag/AgCl_NPs synthesized in the presence of L-Arginine hydrochloride and L-Arginine/KCl mixture. The sugar ligands Lactose p-methoxyaniline (LMA) and Galactose 5-aminosalicylic acid (G5AS) resulted in formation of sheet-like Ag/AgCl_NPs while Lactose sulfanilic acid (LSA) and Lactose psulfonyldianiline (LPSA) caused the formation of anisotropic and film-like Ag/AgCl_NPs. The UV-Vis based mechanistic studies showed that the presence of Arginine posed a strong effect on how G5AS and LMA ligands interact with silver ions while the effect was more complicated for the LSA and LPSA ligands due to the fact that they form complexation with Ag+ ions. The mechanism was further investigated using infrared (IR) studies that showed the increases in Argine and chloride ion concentrations resulted in differentiation of the surface chemistry of the Ag/AgCl_NPs, and appearance of Arginine related IR bands became clearer in the case of cointroduction of Arginine and the sugar ligands. The characterized nanoparticles were then used as antibacterial agent for multidrug resistant Escherichia coli species for which less than 10 mu M minimum inhibitory concentrations were obtained. The promising antibacterial activity, which could be assigned to the presence of Arginine, was independent from the sugar ligand chemistry and nanoparticles' morphology and size. Particularly, large Ag/AgCl_NP film forming capacity can call further research to be exploited as coating materials for antibacterial application.Article The Effectiveness of Genetic Markers and the Role of Environmental Factors in Hip Dysplasia and Osteochondritis Dissecans of the Shoulder in German Shepherd, Labrador Retriever, and German Wirehaired Pointer (Deutsch Drahthaar) Dogs(Elsevier, 2025) Ardicli, Sena; Yigitgor, Pelin; Ozen, Dogukan; Babayev, Huseyn; Bozkurt, Berkay; Senturk, Nursen; Intas, Deniz SeyrekCanine Hip Dysplasia (CHD) is the most frequently diagnosed orthopedic condition in dogs. Similar to CHD, osteochondritis dissecans (OCD) of the shoulder is a developmental disorder in dogs that significantly impacts animal welfare. As polygenic genetic disorders, they exhibit a complex mode of inheritance. Although there are numerous clinical studies, there is insufficient information about the genetic basis of these disorders. Therefore, this study aimed to assess the relationship of the prognostic genetic test markers with CHD and OCD in German Shepherd, Labrador Retriever, and German Wirehaired Pointer dogs. We evaluated the efficiency of five SNP markers from the prognostic genetic test for CHD (the Dysgen test) based on available GWAS data in German Shepherd, Labrador Retriever, and German Wirehaired Pointer dogs. Radiographs were captured and assessed according to the official FCI scale for hip dysplasia. In German Wirehaired Pointers, shoulder X-ray evaluations were also performed. We used custom FRET-based primer probes in Real-time PCR and Sanger sequencing for genotyping and tested the evaluation using multiple logistic regression procedures. German shepherds emerged as the most vulnerable to CHD (P < 0.001). In the final logistic model, females are expected to have a 3.54 times higher likelihood of experiencing CHD compared to males (P < 0.05). SNP BICF2G630558239 demonstrated a notable association with CHD, indicating that the GG genotype poses a risk. This SNP is situated in the intronic region of the KIF26B gene, a member of the kinesin superfamily implicated in evolutionarily conserved roles in embryogenesis. We did not observe any association between shoulder OCD-related arthrosis and the SNPs studied. These results may contribute to understanding CHD by identifying genotypes associated with epidemiological risk, prompting the need to conduct more thorough investigations.Book Part Citation - Scopus: 2Data Driven Leak Detection in a Real Heat Exchanger in an Oil Refinery(Elsevier, 2023) Yasmal, Aslı; Kuşoğlu Kaya, Gizem; Oktay, Emirhan; Çölmekci, Ceylan; Uzunlar, ErdalThis study focuses on implementation of a data-based leak detection method in a heat exchanger in a petroleum refinery. We have studied on the two real leakage cases in a heat exchanger in Izmit TUPRAS Refinery. Leaks are one of the major problems that occur in operations. The autoencoder (AE) method is implemented for leak detection. Reconstruction error is used as the leak indicator. In case of leakage, the reconstruction value is expected to increase. For both cases examined, the reconstruction error is found to be around 1-5 under normal operating conditions. On the other hand, reconstruction error is observed to change between 10 and 60 under the conditions with leakage. Besides, the AE is able to indicate the start of one leakage case before the process engineers noticed it. © 2023 Elsevier B.V.Article Citation - WoS: 4Citation - Scopus: 4Protocol for Cell Surface Biotinylation of Magnetic Labeled and Captured Human Peripheral Blood Mononuclear Cells(Elsevier, 2022) Ayaz Güner, Şerife; Acar, Mustafa Burak; Boyvat, Dudu; Güner, Hüseyin; Bozalan, Habibe; Güzel, Melis; Yıldır, Selin Kübra; Altınsoy, Nilay; Fındık, Fatma; Karakükçü, Musa; Özcan, ServetAnalysis of the surfaceome of a blood cell subset requires cell sorting, followed by surface protein enrichment. Here, we present a protocol combining magnetically activated cell sorting (MACS) and surface biotinylation of the target cell subset from human peripheral blood mononuclear cells (PBMCs). We describe the steps for isolating target cells and their in-column surface biotinylation, followed by isolation and mass spectrometry analysis of biotinylated proteins. The protocol enables in-column surface biotinylation of specific cell subsets with minimal membrane disruption.Conference Object Citation - WoS: 2Citation - Scopus: 3Micromechanical Modeling of Inter-Granular Localization, Damage and Fracture(Elsevier, 2018) Yalçınkaya, Tuncay; Özdemir, İzzet; Fırat, Ali Osman; Tandoğan, İzzet TarıkThe recent developments in the production of miniaturized devices increases the demand on micro-components where the thickness ranges from tens to hundreds of microns. Various challenges, such as size effect and stress concentrations at the grain boundaries, arise due to the deformation heterogeneity observed at grain scale. Various metallic alloys, e.g. aluminum, exhibit substantial localization and stress concentration at the grain boundaries. In this regard, inter-granular damage evolution, crack initiation and propagation becomes an important failure mechanism at this length scale. Crystal plasticity approach captures intrinsically the heterogeneity developing due to grain orientation mismatch. However, the commonly used local versions do not possess a specific GB model and leads to jumps at the boundaries. Therefore, a more physical treatment of grain boundaries is needed. For this purpose, in this work, the Gurtin GB model (Gurtin (2008)) is incorporated into a strain gradient crystal plasticity framework (Yalcinkaya et al. (2011), Yalcinkaya et al. (2012), Yalcinkaya (2017)), where the intensity of the localization and stress concentration could be modelled considering the effect of grain boundary orientation, the mismatch and the strength of the GB. A zero thickness 12-node interface element for the integration of the grain boundary contribution and a 10-node coupled finite element for the bulk response are developed and implemented in Abaqus software as user element subroutines. 3D grain microstructure is created through Voronoi tessellation and the interface elements are automatically inserted between grains. After obtaining the localization, the mechanical behavior of the GB is modelled through incorporation of a potential based cohesive zone model (see Park et al. (2009), Cerrone et al. (2014)). The numerical examples present the performance of the developed tool for the intrinsic localization, crack initiation and propagation in micron-sized specimens. (C) 2018 The Authors. Published by Elsevier B.V.