Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Conference Object Microarc: Event Driven Analysis and Design Method for Microservices(Elsevier B.V., 2025) Yıldız, Ali; Demirors, OnurThe rapid development of the Internet infrastructure has enabled software applications to leverage almost unlimited and scalable resources. Microservice-based architecture has emerged as a solution to harness the benefits of a distributed cloud-based infrastructure. Event-driven architecture is a powerful approach for addressing challenges in distributed systems, such as scalability, distributed data, and sharing of data at scale. In an event-driven microservice architecture, decoupled services interact by responding to events and event streams facilitate data sharing between them. Despite these advantages, there is no de facto method for the analysis and design of systems within microservice architecture. Organizations often face difficulties in developing microservice-based systems, owing to the lack of well-defined methodologies for analysis and design. In this study, we present an analysis and design method for microservice-based systems. MicroArc is a method for analyzing and designing microservice-based systems, and comprises modeling notations, guiding processes to articulate how the method is applied, and a supporting tool for modelling. The MicroArc approach enables the identification of events and microservice candidates by modeling the flow of processes in the early phase of development. © 2025 Elsevier B.V., All rights reserved.Conference Object Dynamic Recognition of the Nucleosome Core Particle by Select Chromatin Factors(Elsevier B.V., 2025) Döseme, H.; Uluçay, T.; Kale, S.The intricate interactions between the nucleosome core particle and chromatin-binding proteins control essential biological functions templated by DNA. The nucleosome is a symmetrical and disc-shaped nucleoprotein which binds several chromatin factors in a 2:1 stoichiometry. We report computational evidence for a DNA-sequence-driven emergence of asymmetry whereby the nucleosome binding affinities of the chromatin factors are altered on each side even though the protein factors bind chemically equivalent proteinous interfaces of the nucleosome. Furthermore, none of these proteins interact directly with the nucleosomal DNA. Using atomistic molecular dynamics simulations, we surveyed five chromatin factors that are known to bind the nucleosome in a 2:1 stoichiometry. In four factors, we found that the nucleosomal gyre that binds DNA strongly is also more preferred. These factors are Sir3, PRC1, RCC1, and SAGA-DUB. However, a fifth chromatin factor, 53BP1, prefers the gyre with the weaker DNA binding with higher affinity. We argue that this tunability in nucleosome affinity could be related to the function of the chromatin interactors as 53BP1 could prefer loose DNA gyres to execute its DNA repair function. © 2025 The Authors. Published by Elsevier B.V.Review Citation - WoS: 5Citation - Scopus: 5Development and Functionalization of Electrospun Fiber Coated Thin Film Microextraction Devices for Rapid Mass Spectrometric Determination of Biologically Important Polar Molecules(Elsevier B.V., 2024) Öztürk,M.; Salih,B.; Eroğlu,A.E.; Boyaci,E.Rapid diagnosis of diseases is one of the challenging areas in clinical research. From the analytical chemist's perspective, the main challenges are isolating the compounds from the bio-specimen and lengthy analysis times. In this regard, solid phase microextraction offers a platform to address the abovementioned challenges. Moreover, its sharp tip-thin film geometry, known as coated blade spray (CBS), can enhance the extraction and act as an ionization source in direct mass spectrometric analysis. In this study, a new CBS device specifically designed for polar analytes was prepared and optimized to determine urinary metabolites. For this purpose, polyacrylonitrile (PAN) was selected as a base polymer as it can be electrospun to form a nanofibrous structure, and it can be modified with weak ion exchange moieties to interact with polar analytes. Following the electrospinning of PAN, hydrolysis was optimized, and conditions leading to sufficient extraction enhancement without dissolving the polymer were obtained when probes were treated with 5.0 M of NaOH for 2.5 h. Using the coated blades prepared as explained, the evaluation of various extraction conditions showed that 5 min is sufficient for equilibrium extraction. In addition, the solution's ionic strength and pH significantly affect the extraction. Optimum sorption was obtained at no salt added and pH 7.0 conditions. The CBS-MS optimization showed that 10.0 µL of ACN/MeOH/H2O (40:40:20, v/v/v) with formic acid kept for 15 seconds on the blade before voltage application leads to the highest signal. The limits of quantification of the analytes are between 50 and 100 ng/mL. © 2024 Elsevier B.V.Article Citation - WoS: 2Citation - Scopus: 2Nanoparticle Manipulation and Sorting by Phased Modulated Interference Pattern of Gaussian Evanescent Waves(Elsevier B.V., 2024) Arslanyurek,; Dinleyici,M.S.The utilization of Gaussian Evanescent Waves (GEWs) in particle manipulation provides a three-dimensional force distribution that is significantly high at the vicinity of the surface and exponentially decreases as one moves away, hence enabling 3D particle manipulation, unlike plane waves. By coherently interfering four GEWs in various phase combinations, symmetric evanescent field distributions can be obtained, which allows the manipulation of nanoparticles for many applications. With the simulation we conducted, the dynamics of various-sized spherical silicon particles in a continuously flowing liquid setup have been investigated. We present the optimal phase-delayed configurations for trapping, sorting, separating, and rotating the particles. © 2024 Elsevier B.V.Article Citation - WoS: 4Citation - Scopus: 3Ligand Engineering for Improving the Stability and Optical Properties of Cspbi3 Perovskite Nanocrystals(Elsevier B.V., 2024) Yuce Cakir,H.; Yalcinkaya,Y.; Demir,M.M.Inorganic lead halide perovskite nanocrystals (NCs) have recently become one of the research topics for optoelectronic applications due to their excellent photophysical properties. Despite their notable thermal stability over organic-inorganic halide perovskites, CsPbI3 NCs suffer from the phase instability of α-CsPbI3 phase at room temperature and under ambient conditions. Here, the effects of 4-Hydroxybenzoic acid (4-HBA) as an additive to standard oleic acid – oleylamine pair on the stability and optical properties of CsPbI3 perovskite NCs are discussed. 4-HBA addition into perovskite NC systems causes a compressive strain on perovskite lattice, which leads to the formation of a mixed phase α- and γ-CsPbI3 phases while pristine perovskite has α-CsPbI3 phase. Time-dependent stability of the perovskite NCs was tested under an ethanol (EtOH) medium. After EtOH exposure of the perovskite NCs, CsPbI3 NCs transformed to non-perovskite phase in 1 h while 4-HBA added CsPbI3 NCs still have perovskite phase after 48 h. In addition to the improved optical properties of the perovskite NCs, 4-HBA addition remarkably improves CsPbI3 perovskite stability. © 2024 Elsevier B.V.Article Citation - WoS: 6Citation - Scopus: 8Thermal Liquefaction of Olive Tree Pruning Waste Into Bio-Oil in Water and Ethanol With Naoh Catalyst(Elsevier B.V., 2024) Öcal,B.; Recepoğlu,Y.K.; Yüksel,A.In this study the effect of catalysts and solvents at varying temperatures on the production of bio-oil from olive tree pruning waste (OPW). The thermal liquefaction process was conducted at 200 °C, 225 °C, and 250 °C for 90 min, employing either water or ethanol as solvents, with alkaline catalysts (0.125 M, 0.25 M, and 0.5 M NaOH) introduced for the first time. Raw material, solid byproducts, and bio-oil samples underwent FTIR analysis for structural changes, TGA for proximate analysis, and GC-MS for bio-oil analysis. Results revealed that NaOH enhanced biomass conversion in water, yet didn't increase bio-oil yield, whereas in ethanol, biomass conversion was relatively lower, but bio-oil yield improved despite the adverse effects of catalyst. The highest biomass conversion (94 %) was achieved at 250 °C with 0.5 M NaOH, but the maximum bio-oil yield (25 %) occurred without a catalyst in water. Conversely, the highest bio-oil yield (55 %) was attained using ethanol without a catalyst at 250 °C. © 2024 Energy InstituteArticle Citation - WoS: 17Citation - Scopus: 24A Gis-Based Fahp and Fedas Analysis Framework for Suitable Site Selection of a Hybrid Offshore Wind and Solar Power Plant(Elsevier B.V., 2023) Karipoğlu, Fatih; Ozturk, S.; Efe, B.This study presents a Geographic Information System (GIS) based suitable site selection methodology for a hybrid system that includes offshore wind and solar PV. The methodology utilizes open source databases about decision criteria and applies this data using GIS to determine suitable sites for offshore wind and solar PV systems. For the assessment of multi-criteria which affect the potential hybrid energy power plants and the determination of the best suitable areas, Fuzzy Analytical Hierarchy Process (FAHP) and Fuzzy Evaluation based on Distance Average Solution (FEDAS) are used in the study. Results show that technical criteria has the priority weight of 0.60 while the weight of social criteria is about 0.07. Among sub-criteria, the wind speed has the highest priority weight while distance to port and visibility are the highest criteria of priority weight under economic and social main criteria, respectively. Among the alternatives, Area 2 (A-2) is determined as the best alternative for hybrid offshore power plants in the study area. This proposed methodology can be utilized by decision-makers to determine the best suitable locations for hybrid offshore wind and solar PV systems at any location. This paper suggests a new approach integrating GIS, fuzzy setbased AHP and EDAS as a novelty. © 2023 International Energy InitiativeArticle Citation - WoS: 24Citation - Scopus: 23Photovoltaic Performance of Magnetron Sputtered Antimony Selenide Thin Film Solar Cells Buffered by Cadmium Sulfide and Cadmium Sulfide /Zinc Sulfide(Elsevier B.V., 2023) Cantas, A.; Gundogan, S.H.; Turkoglu, F.; Koseoglu, H.; Aygun, G.; Ozyuzer, L.Antimony selenide (Sb2Se3)-based thin-film solar cells have recently attracted worldwide attention as an abundant, low-cost, and efficient photovoltaic technology. The highest efficiencies recorded for Sb2Se3 solar cells have been obtained using cadmium sulfide (CdS) as a buffer layer. The Cd-included hybrid buffer layers could be one option to increase device efficiency through more effective usage of light. Therefore, in this work, the effect of single CdS and hybrid CdS/zinc sulfide (ZnS) buffer layers on the photovoltaic performance of Sb2Se3 thin-film solar cells has been investigated in detail. Sb2Se3 thin films have been deposited on molybdenum (Mo)-coated soda-lime glass (SLG) substrates by radio frequency magnetron sputtering technique followed by a post-heat treatment process. The morphological, and structural properties of Sb2Se3 thin films have been investigated by X-Ray Diffraction and Scanning Electron Microscopy. To compare the device performances of single CdS and hybrid CdS/ZnS buffered Sb2Se3 thin-film solar cells, SLG/Mo/Sb2Se3/CdS/ZnS/indium tin oxide (ITO) and SLG/Mo/Sb2Se3/CdS/ITO structures have been fabricated. The findings of this study have revealed a reduction in solar cells’ performance from η=3.93% for CdS buffer to η=0.13% for CdS/ZnS hybrid buffer. The change in the solar cell performance using the CdS/ZnS hybrid buffer has been discussed in detail. © 2023 Elsevier B.V.Article Citation - WoS: 5Citation - Scopus: 9Using Loofah Reinforced Chitosan-Collagen Hydrogel Based Scaffolds In-Vitro and In-Vivo; Healing in Cartilage Tissue Defects(Elsevier B.V., 2023) Baysan, G.; Gunes, O.C.; Turemis, C.; Akokay, Yilmaz, P.; Husemoglu, R.B.; Kara, Ozenler, A.; Perpelek, M.The herein article aims to report a new scaffold design as a loofah-reinforced chitosan-collagen hydrogel composite scaffold with three different cross-linker concentrations (0.1, 0.3, and 0.5 wt. /v%). From the analyses, the scaffold crosslinked with 0.5% genipin; collagen-chitosan hydrogel scaffold reinforced with loofah (L-CCol5) was found to be suitable for further in vitro and in vivo studies due to its interconnected porous structure, water content (∼ 97%) and tan delta (0.221 at 1 Hz) values comparable to that of cartilage tissue. In vitro analyses depicted that the L-CCol5 scaffold supported rabbit mesenchymal stem cells (rMSCs) adhesion and proliferation with its non-cytotoxic feature. Moreover, in vivo cartilage healing studies were performed using New Zealand male rabbits in three groups: empty control, cell-free scaffold, and rMSCs-laden scaffold. The elastic moduli of these three groups were 0.69, 0.90, and 1.18 MPa, respectively. Besides, microcomputer tomography (MicroCT) scannings supported the in vivo biomechanical analyses as cell-laden scaffolds showed better osteochondral healing. It can be concluded that the L-CCol5 scaffold could be a promising construct in osteochondral tissue engineering applications. The findings revealed that osteochondral remodeling precedes articular cartilage, providing insight into tailored therapeutic approaches, disease progress, and treatment consequences. © 2023 Acta Materialia Inc.