Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/11147/7148

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  • Article
    Comparative Optimization of Hot Water and Citric Acid Extraction Methods for Sericin Recovery From Silk Cocoons: In Vitro Antioxidant and Antidiabetic Activities
    (Springer, 2026) Sincar, Bahar; Ozdemir, Feyza; Bicakci, Beyza Tutku; Erdem, Cansu; Yalcin, Dilek; Alamri, Abdulhakeem S.; Bayraktar, Oguz
    Silk sericin, a hydrophilic protein derived from Bombyx mori cocoons, has attracted increasing interest due to its antioxidant, moisturizing, and enzyme-inhibitory properties. Efficient extraction is essential to preserve its biofunctional potential. In this study, sericin was extracted using hot water and 1.25% (w/v) citric acid using autoclave-based heating to achieve pressurized conditions above 100 degrees C. A Box-Behnken Response Surface Methodology (RSM) was applied to systematically evaluate the effects of extraction parameters (temperature and time) and to optimize five key response variables: yield, purity, molecular weight and polydispersity index (PDI), total antioxidant capacity (ABTS), and alpha-glucosidase inhibition activity. The results revealed that higher temperatures (125 degrees C) produced the maximum sericin yield, while moderate conditions (115 degrees C for 45 min) ensured better preservation of antioxidant and antidiabetic activities. Hot acid extraction resulted in significantly enhanced purity and enzymatic inhibition compared to hot water extraction. Sericin fractions above 7 kDa exhibited the strongest bioactivity, as reflected by lower IC50 values in both ABTS and alpha-glucosidase inhibition assays. The optimized hot water citric acid-based method yielded 24.00% sericin with 100.00% purity and an IC50 of 0.67 mg/mL for alpha-glucosidase inhibition. This study compares hot water and hot acid autoclave extractions using Box-Behnken design and evaluates their effects on sericin yield, purity, and bioactivities. Citric acid-based extraction produced higher purity and stronger alpha-glucosidase inhibition, while hot water extraction preserved antioxidant potential more effectively. These findings support the use of citric acid as an eco-friendly and scalable extraction agent and highlight the potential of sericin in biomedical and nutraceutical applications.
  • Article
    Citation - WoS: 4
    Citation - Scopus: 4
    Optimization of Resource-Aware Parallel and Distributed Computing: a Review
    (Springer, 2025) Czarnul, Pawel; Antal, Marcel; Baniata, Hamza; Griebler, Dalvan; Kertesz, Attila; Kessler, Christoph W.; Rakic, Gordana
    This paper presents a review of state-of-the-art solutions concerning the optimization of computing in the field of parallel and distributed systems. Firstly, we contribute by identifying resources and quality metrics in this context including servers, network interconnects, storage systems, computational devices as well as execution time/performance, energy, security, and error vulnerability, respectively. We subsequently identify commonly used problem formulations and algorithms for integer linear programming, greedy algorithms, dynamic programming, genetic algorithms, particle swarm optimization, ant colony optimization, game theory, and reinforcement learning. Afterward, we characterize frequently considered optimization problems by stating these terms in domains such as data centers, cloud, fog, blockchain, high performance, and volunteer computing. Based on the extensive analysis, we identify how particular resources and corresponding quality metrics are considered in these domains and which problem formulations are used for which system types, either parallel or distributed environments. This allows us to formulate open research problems and challenges in this field and analyze research interest in problem formulations/domains in recent years.
  • Book Part
    Citation - Scopus: 1
    A New Stable Solar System for Electricity, Cooling, Heating, and Potable Water Production in Sunny Coastal Areas
    (Springer, 2023) Khani, Leyla; Mohammadpourfard, Mousa
    Nowadays, more attention is paid to provide clean energy products with low environmental pollution in a decentralized way. Many coastal rural areas suffer from freshwater and electricity scarcity, especially in hot weather condition. Meanwhile, these regions have a great access to intense solar radiation and seawater. Hence, it seems logical to use the available solar energy in those places to provide to necessities like power, heating, and cooling. A new solar cooling, power, heating, and freshwater production system is designed, evaluated, and optimized in this research. The proposed system is composed of several subsystems to generate each product with high efficiency and reliability. Solar energy is unavailable at night, so molten salt energy storage is used to establish the steady operation of the system. Then, the system is evaluated from thermodynamic and exergoeconomic viewpoints, and a parametric study is accomplished to study the effect on the system performance of key variables. In the end, the system is optimized to determine its best operating condition for different cases. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.