Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 1Citation - Scopus: 1Investigation of Cytotoxic Properties of Some Isoindole-Related Compounds Bearing Silyl and Azide Groups With in Vitro and in Silico Studies(Taylor & Francis, 2023) Tan, Ayşe; Köse, Aytekin; Mete, Derya; Şanlı Mohamed, Gülşah; Kışhalı, Nurhan H.; Kara, YunusThis study aims to evaluate the synthesis of isoindole-1,3-dione analogues and their cytotoxic potential. A549 and HeLa cells exposed to 250-100-50-25 mu M doses of each derivative were incubated for 24, 48, and 72 h. The cytotoxicity of the isoindole-1,3-dione derivatives was analyzed using the cell growth inhibition assay and the cell membrane damage test. (3aR,5R,6R,7aS)-5-Azido-2-benzyl-6-hydroxyhexahydro-1H-isoindole-1,3(2H)-dione (1d), (3aR,5R,6R,7aS)-5-azido-6-((tert-butyldiphenylsilyl)oxy)-2-ethylhexahydro-1H-isoindole-1,3(2H)-dione (2a), and (3aR,5R,6R,7aS)-5-azido-6-((tert-butyldiphenylsilyl)oxy)-2-methylhexahydro-1H-isoindole-1,3(2H)-dione (2b) compounds inhibited the growth of the A549 and HeLa cells caused membrane damage and exhibited a dose-dependent cytotoxic effect on lung and cervical carcinoma cells. The effect of tert-butyldiphenylsilyl (TBDPS) groups on cytotoxicity was observed in compounds 2a and 2b, but not in the other compounds. Considering the effect of groups attached to the nitrogen atom, the best activity was exhibited in 2b molecule to which the methyl group is attached. Additionally, the interactions of compounds (3aR,5R,6R,7aS)-5-azido-6-hydroxy-2-methylhexahydro-1H-isoindole-1,3(2H)-dione (1b), 1d, 2a and 2b with mammalian rapamycin target, human ribosomal S6 kinase 1 and human epidermal growth factor receptor were investigated by molecular docking studies, . According to the docking results, 2a and 2b compounds containing a TBDPS group have stronger binding energies than 1b and 1d compounds against all target receptors.Article Citation - WoS: 2Citation - Scopus: 3The Green-Tao Theorem and the Infinitude of Primes in Domains(Taylor & Francis, 2022) Göral, Haydar; Özcan, Hikmet Burak; Sertbaş, Doğa CanWe first prove an elementary analogue of the Green-Tao Theorem. The celebrated Green-Tao Theorem states that there are arbitrarily long arithmetic progressions in the set of prime numbers. In fact, we show the Green-Tao Theorem for polynomial rings over integral domains with several variables. Using the Generalized Polynomial van der Waerden Theorem, we also prove that in an infinite unique factorization domain, if the cardinality of the set of units is strictly less than that of the domain, then there are infinitely many prime elements. Moreover, we deduce the infinitude of prime numbers in the positive integers using polynomial progressions of length three. In addition, using unit equations, we provide two more proofs of the infinitude of prime numbers. Finally, we give a new proof of the divergence of the sum of reciprocals of all prime numbers.Article Citation - WoS: 3Citation - Scopus: 5Temperature Dependent Electrical and Electrocaloric Properties of Textured 0.72pmn-0.28pt Ceramics*(Taylor & Francis, 2021) Böbrek, İrem; Berksoy Yavuz, Ayşe; Kaya, M. Yunus; Alkoy, Sedat; Okatan, Mahmut Barış; Mısırlıoğlu, İbrahim Burç; Mensur Alkoy, EbruLead magnesium niobate (PMN) - lead titanate (PT) solid solution ceramics in the ratio of 0.72PMN-0.28PT was produced by a combination of tape-casting in ⟨001⟩(pc) textured and random forms. The Lotgering factor, f, of textured ceramics was approximately calculated as 80%. Modified Curie-Weiss analysis indicated relaxor dominant behavior for both the random and textured ceramics. Development of texture led to an enhancement in the electromechanical properties with converse piezoelectric charge coefficient (d(33)*) under 20 kV/cm electric field reaching 545 pm/V for the textured ceramic. Electrocaloric (EC) behavior of random and textured ceramics were obtained from indirect measurements using temperature dependent polarization vs. electric field hysteresis loops. An EC temperature change (Delta T-EC) of similar to 0.5 K was calculated from the PMN-28PT ceramics at around 80 degrees C under an electric field of 60 kV/cm. Development of texture was demonstrated to have led to an anisotropy in the EC response.Article Citation - WoS: 13Citation - Scopus: 14Landau, Ginzburg, Devonshire and Others(Taylor & Francis, 2020) Levanyuk, Arkady P.; Mısırlıoğlu, İbrahim Burç; Barış Okatan, MahmutMacroscopic modeling of ferroelectric properties refers usually to Landau-Ginzburg-Devonshire theory. This paper questions the meaningfulness of this term, discussing contributions of the three authors in the title to what is supposed to be a theory. The limitations of every contribution are analysed. In the main text and, to more extent in the Supplementary Material, the Landau theory is presented from an unusual perspective starting from simple mechanical models of spontaneous symmetry breaking and finishing by the Ising model. The aim of the presentation is to emphasize along with the qualitative breakthroughs the approximate character of macroscopic modeling associated with the above three authors. © 2020 Taylor & Francis Group, LLC.Article Citation - WoS: 1Citation - Scopus: 1Temperature and Pressure Dependence of the Raman Intensity and Frequency of a Soft Mode Near the Tricritical Point in the Ferroelectric Sbsi(Taylor & Francis, 2016) Yurtseven, Hasan Hamit; Duman, SinemWe analyze the pressure dependence of the intensity and the frequency of a soft mode from the Raman and elastic light scattering experiments as reported in the literature close to the ferroelectric - paraelectric transition in SbSI crystal. The Raman intensity of this mode is analyzed as a function of pressure at constant temperatures of 272K (first order transition) and 234K (tricritical or second order transition) according to a power-law formula. Our analysis of the Raman intensity gives closely the mean field values for the order parameter. From our analysis, we also obtain that the Raman frequency (squared) of the soft mode varies linearly with the pressure at constant temperatures close to the ferroelectric - paraelectric transition in SbSI as obtained experimentally.