Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Citation - WoS: 16Citation - Scopus: 19Comparative Analysis of Estimation of Slope-Length Gradient (ls) Factor for Entire Afghanistan(Taylor & Francis, 2023) Ansari, Ahmad; Tayfur, GökmenSlope length gradient (LS) is one of the crucial factors in the Universal Soil Loss Equations (USLE, RUSLE). This study aimed at estimating the slope-length and slope-steepness (LS) factor for the entire watersheds of Afghanistan by using three different methods, namely; (1) LS-TOOLMFD (Method 1); (2) The Method of Equations (Method 2); and (3) The approach of Moore and Burch (Method 3). The first method uses the digital elevation model (DEM) in the ASCII format, and the other two methods use the DEM in the spatial domain. The results show that the LS-factor of the study area ranges from 0.01 to 44.31, with a mean of 5.24 and standard deviation of 6.95, according to Method 1; 0.03 to 163.49, with a mean of 9.6 and standard deviation of 13.58, according to Method 2; and 0 to 3985, with a mean of 7.16 and standard deviation of 29.7, according to Method 3. The study reveals that Methods 1 and 2 are more appropriate than Method 3 because Method 3 yields high LS-factor values close to or at streamlines located near mountainous regions. The highest LS values are found to be in the northeast, north, and central regions of Afghanistan, which is consistent with the high mountains and deep valley geomorphology, indicating that these regions are particularly vulnerable to soil erosion by rainfall-runoff processes. The sediment delivery ratio (SDR) for the Upper-Helmand River Basin (Upper-HRB) is also estimated by the RUSLE, employing the LS factors produced by the three methods. The results revealed that the average annual soil loss is found to be, respectively, 9.3, 18.2, and 11.1 (ton/ha/year) by using the three methods, corresponding to SDR of 23.5%, 12.1%, and 19.9%.Article Citation - WoS: 5Citation - Scopus: 5Stabilization of Calcareous Subgrade Soils With Polyelectrolytes: Mechanisms and Mechanical Properties(Taylor & Francis, 2023) Huang, Jianxin; Kogbara, Reginald; Mohomad, Yosef; Kogbara, Reginald B.; Masad, Eyad; Sukhishvili, Svetlana; Little, DallasOrganic polyelectrolytes, i.e. anionic poly(sodium 4-styrenesulphonate) (PSS), cationic poly(diallyldimethylammonium chloride) (PDADMAC) and their polyelectrolyte complexes (PECs) were evaluated for stabilisation of calcareous sandy subgrade soil. This paper investigated the effects of polymer type, surface charge type of PEC, concentrations of PEC solutions and dosages of polymer solutions added to the soil on improvement of soil mechanical properties. We found that anionic polymers, for both PECs and individual polyelectrolytes, were superior to their cationic counterparts in improving soil strength. Besides, the constituent polyelectrolytes, PSS and PDADMAC, worked better than their PECs for the specific soil investigated. The strength of polymer-treated soils was also found to increase with the increase in dosages of the polymer solutions as well as curing periods. Furthermore, polymer-treated soil specimens exhibited significant toughness improvement, which was higher than cement-treated samples. Scanning electron microscopy images revealed the abundance of long palygorskite fibres covering the surfaces of larger calcite and dolomite particles and linking surrounding aggregates after adding polymers. This observation suggests the interconnection of palygorskite fibres and their linking networks between and among coarse aggregates as the likely mechanism of polymer stabilisation of the soil studied.Article Citation - WoS: 11Citation - Scopus: 10Redefining methods for augmenting lactic acid bacteria robustness and phenyllactic acid biocatalysis: Integration valorizes simplicity(Taylor & Francis, 2022) Meruvu, HarithaThe production of phenyllactic acid (PLA) has been reported by several researchers, but so far, no mention has been made of augmented PLA production using an orchestrated assembly of simple techniques integrated to improve lactic acid bacteria (LAB) metabolism for the same. This review summarizes sequentially tailoring LAB growth and metabolism for augmented PLA catalysis through several strategies like monitoring LAB sustenance by choosing appropriate starter PLA-producing LAB strains isolated from natural environments, with desirably fastidious growth rates, properties like acidification, proteolysis, bacteriophage-resistance, aromatic/texturing-features, etc.; entrapping chosen LAB strains in novel cryogels and/or co-cultivating two/more LAB strains to improve their biotransformation potential and promote growth dependency/sustainability; adopting adaptive evolution methods designed to improve LAB strains under selection pressure inducing desired phenotypes tolerant to stress factors like heat, salt, acid, and solvent; monitoring physico-chemical LAB fermentation factors like temperature, pH, dissolved oxygen content, enzymes, and cofactors for PLA biosynthesis; and modulating purification/downstream processes to extract substantial PLA yields. This review paper serves as a comprehensive preliminary guide that can evoke a strategic experimental plan to produce industrial-scale PLA yields using simple techniques orchestrated together in the pursuit of conserving time, effort, and resources.Article Citation - WoS: 30Citation - Scopus: 33Targeting the Panoptosome With 3,4-Methylenedioxy Reduces Panoptosis and Protects the Kidney Against Renal Ischemia-Reperfusion Injury(Taylor & Francis, 2022) Uysal, Erdal; Dokur, Mehmet; Küçükdurmaz, Faruk; Altınay, Serdar; Polat, Sait; Batçıoğlu, Kadir; Sezgin, EfeObjectıves: The objectives of this study were a) to investigate the effect of targeting the PANoptosome with 3,4-methylenedioxy-β-nitrostyrene (MNS) on PANoptosis in the Renal ischemia-reperfussion (RIR) model b) to investigate the kidney protective effect of MNS toward RIR injury. Methods: Thirty-two rats were divided into four groups randomly. The groups were assigned as Control, Sham, DMSO (dimethyl sulfoxide) and MNS groups. The rats in the MNS group were intraperitoneally given 20 mg/kg of MNS 30 minutes before reperfusion. 2% DMSO solvent that dissolves MNS were given to the rats in DMSO group. Left nephrectomy was performed on the rats under anesthesia at the 6th hour after reperfusion. Glutathione peroxidase (GPx), malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD) and 8-Okso-2′-deoksiguanozin (8-OHdG) levels were measured. Immunohistochemical analysis, electron microscopic and histological examinations were carried out in the tissues. Results: Total tubular injury score was lower in the MNS group (p < 0.001). Caspase-3, Gasdermin D and MLK (Mixed Lineage Kinase Domain Like Pseudokinase) expressions were considerably decreased in the MNS group (p < 0.001). Apoptotic index (AI) was found to be low in the MNS group (p < 0.001). CAT and SOD levels were higher in the MNS Group (p = 0.006, p = 0.0004, respectively). GPx, MDA, and 8-OH-dG levels were similar (p > 0.05) in all groups. MNS considerably improved the tissue structure, based on the electron microscopic analysis. Conclusıons: Our results suggested that MNS administrated before the reperfusion reduces pyroptosis, apoptosis and necroptosis. These findings suggest that MNS significantly protects the kidney against RIR injury by reducing PANoptosis as a result of specific inhibition of Nod-like receptor pyrin domain-containing 3 (NLRP 3), one of the PANoptosome proteins.Article Citation - WoS: 7Citation - Scopus: 6An Intervention Framework for Developing Interactive Video Lectures Based on Video Clickstream Behavior: a Quasi-Experimental Evaluation(Taylor & Francis, 2022) Yürüm, Ozan Raşit; Yıldırım, Soner; Taşkaya Temizel, TuğbaThe purpose of this study is to develop an intervention framework based on video clickstream interactions for delivering superior user experience for video lectures. Apart from existing studies on data-driven interventions, this study focuses on video clickstream interactions to identify timely interventions for creating interactive video lectures. First, a framework was developed through an exploratory experiment, in which 29 students’ clickstream behaviors were tracked on an online platform and then individual interviews were held with 17 of the students and a subject-matter expert. The framework shows how click types are transformed into interactive elements with five question types (where, why, which, how, what). It includes click types, click reasons, interventions, actions, and interactive elements. Then, a quasi-experimental study was performed with 18 students to investigate the effect of the proposed framework on the students’ satisfaction and engagement. The results showed that students’ satisfaction significantly increased for interactive videos created using the proposed framework when motivation was controlled. In addition, students’ frequency to go back to important points decreased significantly in interactive videos, whilst students’ frequency to skip unimportant points increased significantly in interactive videos. In conclusion, the proposed framework can be used to transform linear videos to interactive videos.Article Citation - WoS: 35Citation - Scopus: 42Lactic Acid Bacteria: Isolation–characterization Approaches and Industrial Applications(Taylor & Francis, 2022) Meruvu, Haritha; Tellioğlu Harsa, ŞebnemThe current state-of-art research pertaining to lactic acid bacteria (LAB) calls for the screening and isolation of robust LAB strains to achieve holistic exploitation of LAB and their metabolites of marketable importance. Hence it is imperative to comprehend LAB sources, growth requisites, isolation and characterization strategies necessary for featured cataloging and appropriate culturing. This review comprehensively describes various growth media and biomasses used for supporting LAB sustenance, assay procedures needed for the isolation and characterization of LAB strains, and their application in diverse sectors. The various industrial patents and their summarized claims about novel LAB strains isolated and identified, methods and media (used for detection/screening, isolation, adaptation, culturing, preservation, growth improvement), the techniques and/or methodologies supporting LAB fermentation, and applications of produced industrial metabolites in various market scenarios are detailedArticle Citation - WoS: 36Citation - Scopus: 40Land Deformation and Sinkhole Occurrence in Response To the Fluctuations of Groundwater Storage: an Integrated Assessment of Grace Gravity Measurements, Icesat/Icesat-2 Altimetry Data, and Hydrologic Models(Taylor & Francis, 2021) Khorrami, Behnam; Arık, Fetullah; Gündüz, OrhanUncontrolled extraction of water from groundwater aquifers causes groundwater depletion, which in turn triggers the formation of sinkholes in many parts of the world. Monitoring and detection of these geomorphologic features are of utmost importance and priority for the decision-makers to minimize significant environmental as well as socio-economic implications of land deformation. In this study, a systematic approach is proposed to investigate the spatio-temporal associations of groundwater storage changes with sinkhole evolution and land deformation by using a number of remotely sensed and modeled data as well as in-situ observations. The proposed approach is implemented and tested in Konya Closed Basin (KCB), Turkey, which is one of the most critical areas in central Turkey concerning sinkhole formation. The results of GRACE (Gravity Recovery and Climate Experiment) estimates suggest that there is a descending trend in the temporal variations of TWSA (Terrestrial Water Storage Anomalies) and GWSA (Groundwater Storage Anomalies) over KCB with an average storage depletion of 4.12 ± 0.34 cm/yr and 3.40 ± 0.61 cm/yr, respectively. The analysis of land deformation from ICESat/ICESat-2 (Ice, Cloud, and Land Elevation Satellite) altimetry data also indicates a descending trend with an estimated average vertical displacement of 5 cm/yr for the study area, which seems to be in rational accord with the sinkhole evolution over KCB. The results further suggest that the sinkhole evolution over KCB has an acceptable association with the variations of groundwater storage, groundwater use, and precipitation.Review Citation - WoS: 10Citation - Scopus: 10Authentication of Vinegars With Targeted and Non-Targeted Methods(Taylor & Francis, 2023) Çavdaroğlu, Çağrı; Çavdaroğlu, Çağrı; Özen, Banu; Özen, Fatma BanuThere has been a growing interest in vinegar, especially after the increasing reports about its beneficial health effects. Bioactive compounds of vinegar are associated with its antimicrobial, antioxidant, antidiabetic, antitumor, and anti-obesity types of activities. Quality of vinegar is related with the authenticity of the product besides the amounts of bioactive compounds in its composition. Addition of cheaper substitutes to higher quality vinegars and false labeling are some common authentication problems for this product. There are various examples of the use of targeted and untargeted methods in authentication studies for vinegars. Specific constituents and properties of vinegars such as molecular isotope ratios and individual volatile compounds were used to detect adulteration with targeted methods. On the other hand, untargeted methods, mostly in the form of the application of spectroscopic techniques, such as infrared and fluorescence spectroscopy in combination with chemometrics, provide an overall measurement. This review mainly focuses on adulteration types and elaborates on different targeted and non-targeted methods used to authenticate vinegars.Article Citation - WoS: 73Citation - Scopus: 94In Vitro Evaluation of Spirulina Platensis Extract Incorporated Skin Cream With Its Wound Healing and Antioxidant Activities(Taylor & Francis, 2017) Güneş, Seda; Tamburacı, Sedef; Conk Dalay, Meltem; Deliloğlu Gürhan, İsmetContext: Algae have gained importance in cosmeceutical product development due to their beneficial effects on skin health and therapeutical value with bioactive compounds. Spirulina platensis Parachas (Phormidiaceae) is renowned as a potential source of high-value chemicals and recently used in skincare products. Objective: This study develops and evaluates skin creams incorporated with bioactive S. platensis extract. Materials and methods:Spirulina platensis was cultivated, the aqueous crude extract was prepared and in vitro cytotoxicity of S. platensis extract in the range of 0.001-1% concentrations for 1, 3 and 7d on HS2 keratinocyte cells was determined. Crude extracts were incorporated in skin cream formulation at 0.01% (w/w) concentration and in vitro wound healing and genotoxicity studies were performed. Immunohistochemical staining was performed to determine the collagen activity. Results: 0.1% S. platensis extract exhibited higher proliferation activity compared with the control group with 198% of cell viability after 3 d. Skin cream including 1.125% S. platensis crude extract showed enhanced wound healing effect on HS2 keratinocyte cell line and the highest HS2 cell viability % was obtained with this concentration. The micronucleus (MN) assay results indicated that S. platensis extract incorporated creams had no genotoxic effect on human peripheral blood cells. Immunohistochemical analysis showed that collagen 1 immunoreactivity was improved by increased extract concentration and it was strongly positive in cells treated with 1.125% extract incorporated skin cream. Conclusions: The cell viability, wound healing activity and genotoxicity results showed that S. platensis incorporated skin cream could be of potential value in cosmeceutical and biomedical applications.