Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Design Strategies to Optimize Polymeric Vectors for mRNA Delivery(Taylor and Francis Ltd., 2025) Turhan, Z.Y.; Savaş, M.; Alakbarov, A.; Bulmus, V.mRNA holds great promise for preventing and treating a variety of diseases, from infectious diseases to diverse cancers, owing to its transient expression, lack of genomic integration, and scalable production. Among non-viral vectors, polymeric carriers are attractive due to their synthetic versatility and stability, which allow for precise tuning for efficient mRNA delivery. Their scalability further supports the applicability of polymeric vectors. Studies have addressed the room for improvement in polymeric systems for mRNA delivery and have adapted varying approaches depending on the type of polymeric structure, including but not limited to PEGylation, hydrophobic modification, and incorporation of responsive or targeting moieties. This review summarizes advances in polymeric vectors for mRNA delivery and highlights how distinct structural modifications influence toxicity, mRNA transfection efficiency, biodistribution, intracellular trafficking and immune activation, providing a framework for the rational design of next-generation polymeric vectors that can fully realize the clinical potential of mRNA therapeutics. © 2025 Taylor & Francis Group, LLC.Article Citation - WoS: 1Citation - Scopus: 1Optimized Lithium(I) Recovery From Geothermal Brine of Germencik, Türkiye, Utilizing an Aminomethyl Phosphonic Acid Chelating Resin(Taylor and Francis Ltd., 2025) Recepoğlu, Y.K.This study investigates the performance of Lewatit TP 260 ion exchange resin for the efficient recovery of lithium (Li(I)) from geothermal water sourced from the Germencik Geothermal Power Plant in Türkiye. A series of batch sorption experiments were performed to evaluate the influence of key parameters, including resin dosage, solution pH, temperature, initial Li(I) concentration, and contact time, on the Li(I) recovery process. The optimal conditions were determined to be a resin dose of 0.5 g per 25 mL of geothermal water, pH in the range of 6–8, and a temperature of 25°C. Under these conditions, the resin achieved a maximum Li(I) recovery rate of 71% from the geothermal water. Sorption isotherms were further analyzed using the Langmuir, Freundlich, and Dubinin-Radushkevich (D-R) models. Among these, the Langmuir model provided the best fit (R² = 0.9841), suggesting a maximum sorption capacity (qm) of 4.31 mg/g. Continuous recovery experiments conducted in column mode confirmed the practical applicability of Lewatit TP 260, achieving a total sorption capacity of 0.41 mg Li(I)/mL resin. The findings exhibit the potential of this resin as a viable sorbent for sustainable Li(I) extraction from geothermal brines, supporting the development of green energy technologies and contributing to the circular economy. © 2024 Taylor & Francis Group, LLC.Article Citation - WoS: 5Citation - Scopus: 5On simple-direct modules(Taylor and Francis Ltd., 2021) Büyükaşık, Engin; Demir, Özlem; Diril, MügeRecently, in a series of papers “simple” versions of direct-injective and direct-projective modules have been investigated. These modules are termed as “simple-direct-injective” and “simple-direct-projective,” respectively. In this paper, we give a complete characterization of the aforementioned modules over the ring of integers and over semilocal rings. The ring is semilocal if and only if every right module with zero Jacobson radical is simple-direct-projective. The rings whose simple-direct-injective right modules are simple-direct-projective are fully characterized. These are exactly the left perfect right H-rings. The rings whose simple-direct-projective right modules are simple-direct-injective are right max-rings. For a commutative Noetherian ring, we prove that simple-direct-projective modules are simple-direct-injective if and only if simple-direct-injective modules are simple-direct-projective if and only if the ring is Artinian. Various closure properties and some classes of modules that are simple-direct-injective (resp. projective) are given. © 2020 Taylor & Francis Group, LLC.Correction Corrigendum To “ankos Publisher Application System and Its Impact on the E-Resource Evaluation Process” [serials Review 39 (2013) 29–36](Taylor and Francis Ltd., 2013) Bulut, Burcu; Uğur, Handan; Gürdal, Gültekin; Holt, İlkay; Çukadar, Sami; Akbayrak, Emre H.; Çelebi, Mustafa K.[No abstract available]Article Citation - WoS: 18Citation - Scopus: 19A Suppressed Demand Analysis Method of the Transportation Disadvantaged in Policy Making(Taylor and Francis Ltd., 2009) Duvarcı, Yavuz; Mizokami, ShoshiThis paper proposes a method for estimating transportation supply requirements when the suppressed demand of the transportation disadvantaged (TD) can be calculated and added to existing demand for travel. The underlying assumption is that the travel conditions of these TD groups must be equal to the 'conventional' demand, known as 'full release'. Utilising the modelling approach for TD, suppressed demand analysis, diagnosis of difficulties and equity between conventional and disadvantaged groups were realised, while elaborating special cases for the most vulnerable TD groups (such as elderly and disabled persons) and simultaneously identifying areas of difficulty. From the early virtual results, it is concluded that, for the full release of suppressed trips (only a 5% increase), policy makers must be ready to face some financial burdens, requiring coordination of effort to both standardise these TD groups and reduce the costs incurred by operators.Article Citation - WoS: 2Citation - Scopus: 2Integrally Closed Rings Which Are Prufer(Taylor and Francis Ltd., 2019) Ay Saylam, BaşakLet R be a commutative ring with zero divisors. It is well known that if R is integrally closed, then R is a Prufer domain if and only if there is an integer n > 1 such that, for all . We soften this result for commutative rings with zero divisors by proving that this integer n does not have to work for all a, b is an element of R.Article Citation - WoS: 18Citation - Scopus: 17Wetting of Single Crystalline and Amorphous Silicon Surfaces: Effective Range of Intermolecular Forces for Wetting(Taylor and Francis Ltd., 2020) Özçelik, Hüseyin Gökberk; Özdemir, Abdullah Cihan; Kim, Bohung; Barışık, MuratWetting at nanoscale is a property of a three-dimensional region with a finite length into the solid domain from the surface. Understanding the extent of the solid region effective on wetting is important for recent coating applications as well as for both crystalline and amorphous solids of different atomic ordering. For such a case, we studied the wetting behaviour of silicon surfaces at various crystalline and amorphous states. Molecular distributions of amorphous systems were varied by changing the amorphisation conditions of silicon. Semi-cylindrical water droplets were formed on the surfaces to be large enough to remain independent of line tension and Tolman length effects. Contact angles showed up to 38% variation by the change in the atomic orientation of silicon. Instead of a homogeneous solid density definition, we calculated different solid densities for a given surface measured inside different extents from the interface. We correlated the observed wetting variation with each of these different solid densities to determine which extent governs the wetting variation. We observed that the variation of solid density measured inside a 0.13 nm extent from the surface reflected the variation of wetting angle better for both single crystalline and amorphous silicon surfaces.Article Citation - WoS: 4Citation - Scopus: 4The Effect of Cell Wall Material Strain and Strain-Rate Hardening Behaviour on the Dynamic Crush Response of an Aluminium Multi-Layered Corrugated Core(Taylor and Francis Ltd., 2021) Güden, Mustafa; Canbaz, İlkerThe effect of the parameters of the Johnson and Cook material model on the direct impact crushing behaviour of a layered 1050 H14 aluminium corrugated structure was investigated numerically in LS-DYNA at quasi-static (0.0048 m s(-1)) and dynamic (20, 60, 150 and 250 m s(-1)) velocities. Numerical and experimental direct impact tests were performed by lunching a striker bar onto corrugated samples attached to the end of the incident bar of a Split Hopkinson Pressure Bar set-up. The numerical impact-end stress-time and velocity-time curves were further compared with those of rigid-perfectly-plastic-locking (r-p-p-l) model. Numerical and r-p-p-l model impact-end stress analysis revealed a shock mode at 150 and 250 m s(-1), transition mode at 60 m s(-1) and quasi-static homogenous mode at 20 m s(-1). The increase of velocity from quasi-static to 20 m s(-1) increased the numerical distal-end initial peak-stress, while it almost stayed constant between 20 and 250 m s(-1) for all material models. The increased distal-end initial peak-stress of strain rate insensitive models from quasi-static to 20 m s(-1) confirmed the effect of micro-inertia. The numerical models further indicated a negligible effect of used material models on the impact-end stress of investigated structure. Finally, the contribution of strain rate to the distal-end initial peak-stress of cellular structures made of low strain rate sensitive Al alloys was shown to be relatively low as compared with that of strain hardening and micro-inertia, but it might be substantial for the structures constructed using relatively high strain rate sensitive alloys.Article Citation - WoS: 5Citation - Scopus: 5A Hybrid Process for 2,4-Dichlorophenoxy Acetic Acid Herbicidal Treatment and Its Microbial Identification by Maldi-Tof Mass Spectrometry(Taylor and Francis Ltd., 2020) Doğdu Okçu, Gamze; Ökten, Hatice Eser; Yalçuk, ArdaThe feasibility of coupling photocatalysis and a biological treatment to remove a herbicide–2,4-dichlorophenoxy acetic acid (2,4-D)–from pure water was examined using batch experiments following three protocols: aerated (A-BR) and non-aerated biodegradation (NA-BR) alone, and intimately combined photodegradation and biodegradation (P-B). In view of a subsequent biological treatment, 15 and 180 min irradiation times were chosen in accordance with spectrophotometric and LC-MS/MS results that indicated the decrease in the COD/TOC ratio during photocatalysis. Pre-treatment led to a quick decrease in concentration of 2,4-D and COD during the biological process: a 78.79 ± 0.30% COD removal and 38.23 ± 3.12% 2,4-D elimination was measured after 5760 min in A-BR, and 80.89 ± 0.81% COD and 81.36 ± 1.37% 2,4-D removal was achieved after 2880 min in P-B. For species identification using matrix-assisted laser desorption/ionization (MALDI)-time of flight (TOF)-TOF/MS equipment, Aeromonas eucrenophila, Stenotrophomonas acidaminiphila, Ralstonia pickettii, Sphingobacterium multivorum and Acinetobacter towneri were identified with high accuracy, and they play important roles in the degradation of 2,4-D.Article Citation - WoS: 3Citation - Scopus: 3Feasible Packing of Granular Materials in Discrete-Element Modelling of Cone-Penetration Testing(Taylor and Francis Ltd., 2018) Ecemiş, Nurhan; Bakunowicz, PaulinaThis paper explores how the discrete-element method (DEM) was found to play an increasingly important role in cone penetration test (CPT) where continuum-mechanics-based analysis tools are insufficient. We investigated several crucial features of CPT simulations in the two-dimensional DEM. First, the microparameters (stiffness and friction) of discrete material tailored to mimic clean, saturated sand, which is used in cone-penetration tests, were calibrated by curve-fitting drained triaxial tests. Then, three series of cone-penetration simulations were conducted to explore (1) top boundary conditions, (2) reasonable size of discrete particles at different initial porosities, and (3) limit initial porosity of the model for a balance between accurate representation and computational efficiency. Further, we compared the cone-penetration resistance obtained in the laboratory and numerical simulations for the range of relative densities.