Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/11147/7148
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Article Preparation and Characterization of Hydroxyapatite Reinforced Polymeric Scaffolds(Natl Inst Science Communication-NISCAIR, 2025) Firata, Duygu Doga; Ersoz, Su Turku; Burcu Alp, Fatma; Cetin, Ali Emrah; Ciftcioglu, MuhsinPorous HA reinforced PLA/PCL scaffolds with polymer volume percentages in the 7.0-7.6 range have been prepared by solvent-casting/salt leaching technique. The scaffolds have been characterized by conducting gravimetric measurements, FTIR analysis, TGA, X-ray diffraction analysis, compression tests, cell viability tests, and thermal and hydrolytic degradation tests in order to investigate the effect of PLA/PCL, PLA/HA, PCL/HA and PLA/PCL/HA blending on scaffold properties. Porosity of the scaffolds has been determined to be in the 83-92 percent range. The scaffold porosity has decreased with HA content. The water absorption of the scaffolds has been found to be in between 400 and 750%. The yield strength and the elastic modulus of the scaffolds have been determined to be in the 0.001-0.02 and 5.6-10.6 MPa ranges, respectively. The yield strength of the scaffolds has increased by both PCL and HA contents whereas elastic modulus has increased with PCL content but has decreased with HA content. Mechanical test results have indicated that the addition of HA has increased the strength of the scaffolds while decreasing their flexibility. The activation energies for the thermal degradation of the scaffolds have been determined to be in the 130-398 kJ/mol range and have been shown to be a function of PCL, PLA, and HA content. The hydrolytic degradation behavior of the scaffolds in acetate buffer solutions (pH=4.5) during 127 days and XRD analysis have indicated that the hydrolytic degradation occurring in the amorphous part of the surface film has been diffusion-controlled. The diffusion coefficients of the degradation products in the scaffolds have been estimated to be in the 1.21-4.95x10(-13) m(2)/s range. Cell viability test results have indicated that the composition of the composite scaffold structure has played a determining role in the prepared scaffolds.Book Part Citation - Scopus: 3Tissue Engineering Applications of Marine-Based Materials(Springer, 2022) Polat, Hürriyet; Zeybek, Nuket; Polat, MehmetTissue engineering is a promising approach in replacing or improving tissues lost or has become nonviable due to disease or trauma by the use of scaffold materials by combining engineering and biochemical/physicochemical methods. Its purpose is to create suitable matrices that support cell differentiation and proliferation toward the formation of new and functional tissue. Marine-based natural compounds are potential scaffold feedstock material in tissue engineering owing to their biocompatibility and biodegradability while providing excellent biochemical/physicochemical properties. Numerous application areas and various fabrication routes techniques described in the literature attest to the importance of these materials in tissue regeneration. This review has been carried to merge the information from a large number of studies on the marine-based scaffold materials in tissue engineering into a coherent summary. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.Article Citation - WoS: 43Citation - Scopus: 47Bioactive Diatomite and Poss Silica Cage Reinforced Chitosan/Na-carboxymethyl Cellulose Polyelectrolyte Scaffolds for Hard Tissue Regeneration(Elsevier, 2019) Tamburacı, Sedef; Kimna, Ceren; Tıhmınlıoğlu, FundaRecently, natural polymers are reinforced with silica particles for hard tissue engineering applications to induce bone regeneration. In this study, as two novel bioactive agents, effects of diatomite and polyhedral oligomeric silsesquioxanes (POSS) on chitosan (CS)/Na-carboxymethylcellulose (Na-CMC) polymer blend scaffolds are examined. In addition, the effect of silica reinforcements was compared with Si-substituted nano-hydroxyapatite (Si-Hap) particles. The morphology, physical and chemical structures of the scaffolds were characterized with SEM, liquid displacement, FT-IR, mechanical analysis, swelling and degradation studies. The particle size and the crystal structure of diatomite, POSS and Si-Hap particles were determined with DLS and XRD analyses. In vitro studies were performed to figure out the cytotoxicity, proliferation, ALP activity, osteocalcin production and biomineralization to demonstrate the promising use of natural silica particles in bone regeneration. Freeze-dried scaffolds showed 190-307 mu m pore size range and 61-70% porosity. Both inorganic reinforcements increased the mechanical strength, enhanced the water uptake capacity and fastened the degradation rate. The nanocomposite scaffolds did not show any cytotoxic effect and enhanced the surface mineralization in osteogenic medium. Thus, diatomite and POSS cage structures can be potential reinforcements for nanocomposite design in hard tissue engineering applications.